Skip to main content
SpringerLink
Log in

Gastric Lipase: Characteristics and Biological Function of Preduodenal Digestive Lipases

  • Chapter
Book cover Esterases, Lipases, and Phospholipases

Part of the book series: NATO ASI Series ((NSSA,volume 266))

  • 116 Accesses

Abstract

In this chapter we will discuss gastric lipase and, briefly, other preduodenal lipases with similar function. The emphasis will be on the function of these lipases in the process of fat digestion in health and disease.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. M. Hamosh, and R.O. Scow, Lingual lipase and its role in the digestion of dietary lipid, J Clin Invest. 52 (1973) 88–95

    Article  PubMed  CAS  Google Scholar 

  2. G.H. Wise, P.G. Miller, and G.W. Anderson, Changes observed in milk “sham-fed” to dairy calves, Dairy Sci. 23 (1940) 997–1001

    Article  CAS  Google Scholar 

  3. C.S. Fink, M. Hamosh, P. Hamosh, S.J. DeNigris, and D.K. Kasbekar, Lipase secretion from dispersed rabbit gastric glands, Am J Physiol. 248 (1985) G68 - G72

    PubMed  CAS  Google Scholar 

  4. M. Hamosh, D. Ganot, and P. Hamosh, Rat lingual lipase. J Biol Chem. 254 (1979) 12121–12125

    PubMed  CAS  Google Scholar 

  5. R.B. Field, and R.O. Scow. Purification and characterization of rat lingual lipase, J Biol Chem. 258 (1983) 14563–14569

    PubMed  CAS  Google Scholar 

  6. I.M. Roberts, R.J. Montgomery, and M.C. Carey, Lingual lipase: partial purification, hydrolytic properties and comparison with pancreatic lipase, Am J Physiol. 247 (1984) G385 - G393

    PubMed  CAS  Google Scholar 

  7. B.J. Sweet, L.C. Matthews, and T. Richardson., Purificiation and characterization of pregastric esterase of calf., Arch Biochem Biophys. 234 (1984) 144–150

    Article  PubMed  CAS  Google Scholar 

  8. S. Bernback, O. Hernell, and L. Blackberg, Purification and molecular characterization of bovine pregastric esterase, Eur J Biochem. 148 (1985) 233–238

    Article  PubMed  CAS  Google Scholar 

  9. C. Tiruppathi, and K.A. Balasubramanian, Purification and properties of an acid lipase from human gastric juice, Biochim Biophys Acta. 712 (1982) 692–697

    Article  PubMed  CAS  Google Scholar 

  10. C. Tiruppathi, and K.A. Balasubramanian, Single-step purification and amino acid and lipid composition of purified acid lipase from human gastric juice, Indian J Biochem Biophys. 22 (1985) 111–114

    PubMed  CAS  Google Scholar 

  11. H. Moreau, Y. Gargouri, D. Lecat, J.L. Junien, and R. Verger, Purification, characterization and kinetic properties of the rabbit gastric lipase, Biochim Biophys Acta 960 (1988) 286–293

    Article  PubMed  CAS  Google Scholar 

  12. F. Carriere, H. Moreau, and V. Raphel. Purification and biochemical characterization of dog gastric lipase, Eur J Biochem. 202 (1991) 75–83

    Article  PubMed  CAS  Google Scholar 

  13. A.J.P. Docherty, M.W. Bodmer, S. Angal et al., Molecular cloning and nucleotide sequence of rat lingual lipase cDNA, Nucleic Acid Res. 13 (1985) 1891–1903

    Article  PubMed  CAS  Google Scholar 

  14. M.W. Bodmer, S. Angal, G.T. Yarraton, et al.., Molecular cloning of a human gastric lipase and expression of the enzyme in yeast, Biochim Biophys Acta 909 (1987) 237–244

    Article  PubMed  CAS  Google Scholar 

  15. H. Moreau, C.Abergel, F. C.rriere et al., Isoform purification of gastric lipases, J Mol Biol. 225 (1992) 147–153

    Google Scholar 

  16. S. Bernback, and L. Blackberg, Human gastric lipase. The N-terminal tetrapeptide is essential for lipid binding and lipase activity, Eur J Biochem. 182 (1989) 495–499

    Article  PubMed  CAS  Google Scholar 

  17. S.J. DeNigris M. Hamosh, D.K. Kasbekar, T.C. Lee, and P. Hamosh, Lingual and gastric lipases: species differences in the origin of prepancreatic digestive lipases and in localization of gastric lipase, Biochim Biophys Acta 959 (1988) 38–45

    Article  PubMed  Google Scholar 

  18. H. Moreau, Y. Gargouri, D. Lecat, J.L Junien, and R. Verger, Screening of preduodenal lipases in several mammals, Biochim Biophys Acta 959 (1988) 247–252

    Article  PubMed  CAS  Google Scholar 

  19. S.J. DeNigris, M. Hamosh, D.K. Kasbekar, C.S. Fink, T.C. Lee, and P. Hamosh., Human gastric lipase: Secretion from dispersed gastric glands, Biochim Biophys Acta 836 (1985) 67–72

    Article  PubMed  CAS  Google Scholar 

  20. M. Hamosh, and W.A.Burns, Lipolytic activity of human lingual glands (Ebner), Lab Invest. 37 (1977) 603–608

    PubMed  CAS  Google Scholar 

  21. M. Hull, and R.W. Keaton, The existence of a gastric lipase, JBiol Chem. 32 (1917) 127–140

    CAS  Google Scholar 

  22. G.R. Douglas, A.J. Reinauer, W.C. Brooks, and J.H. Pratt, The effect on digestion and absorption of excluding the pancreatic juice from the intestine, Gastroenterology 23 (1953) 452–459

    PubMed  CAS  Google Scholar 

  23. C.L. Kirk, S.J. Iverson, and M. Hamosh, Lipase and pepsin activities in the stomach mucosa of the suckling dog, Biol Neonate 59 (1991) 78–85

    Article  PubMed  CAS  Google Scholar 

  24. J.P. Perret, Lipolyse gastrique chez le lapereau. Origine et importance physiologique de la lipase, J Physiol. 78 (1982) 221–230

    CAS  Google Scholar 

  25. H. Moreau, A. Bernadac, N. Tretout, Y. Gargouri, F. Ferrato, and R. Verger, Immunocytochemical localization of rabbit gastric lipase and pepsinogen, Eur J Cell Biol. 51 (1990) 165–169

    PubMed  CAS  Google Scholar 

  26. F. Volhard, Uber das Fettspaltende Ferment des Magens, Z Klin Med. 43 (1901) 397–401

    Google Scholar 

  27. I.M. Roberts, and R. Jaffe, Lingual lipase: immunocytochemical localization in the rat von Ebner gland, Gasteroenterology 90 (1986) 1170–1175

    CAS  Google Scholar 

  28. J. Toothill, S.W. Thompson, and J.D. Edwards-Webbs, Studies on lipid digestion in the preruminant calf. The source of lipolytic activity in the abomasum, Br J Nutr. 36 (1976) 439–447

    Article  PubMed  CAS  Google Scholar 

  29. H.A. Ramsey, G.H. Wise, and S.B. Tove, Esterolytic activity of certain alimentary and related tissues from cattle in different age group, J Dairy Sci. 39 (1956) 1312–1321

    Article  CAS  Google Scholar 

  30. J.W.F. Grosskopf, Studies on salivary lipase in young ruminants, Onderstepoort J Vet Res. 32 (1965) 153–180

    PubMed  CAS  Google Scholar 

  31. M. Hamosh, and A.R. Hand, Development of secretory activity in serous cells of the rat tongue, Dev Biol. 65 (1978) 100–113

    Article  PubMed  CAS  Google Scholar 

  32. I.M. Roberts, L.E. Nochomovitz, R. Jaffe, S.I. Hand, M. Rojas, and R.A. Agostini Jr, Immunochemical localization of lingual lipase in serous cells of the developing rat tongue, Lipids 22 (1987) 764–766

    Article  PubMed  CAS  Google Scholar 

  33. M. Hamosh, J.W. Scanlon, D. Ganot, M. Likel, K. B. Scanlon, and P. Hamosh, Fat digestion in the newborn: characterization of lipase in gastric aspirates of premature and term infants, J Clin Invest. 67 (1981) 838–846

    Article  PubMed  CAS  Google Scholar 

  34. J. Sarles, H. Moreau, and R. Verger, Human gastric lipase: ontogeny and variations in children, Acta Paediatr. 81 (1992) 511–513

    Article  PubMed  CAS  Google Scholar 

  35. J.S. DiPalma, C. Kirk, M. Hamosh, A.R. Colon, S.B. Benjamin, and P. Hamosh, Lipase and pepsin activity in the gastric mucosa of infants, children and adults, Gastoenterology 101 (1991) 116–121

    CAS  Google Scholar 

  36. P.C. Lee, R. Borysewicz, M. Struve, K. Raab, and S.L. Werlin, Development of lipolytic activity in gastric aspirates from premature infants, J Pediatr Gastroenterol Nutr. In Press (1993).

    Google Scholar 

  37. C.K. Abrams, M. Hamosh, and T.C. Lee, et al, Gastric lipase: location in the human stomach, Gastroenterology 95 (1988) 1460–1464

    PubMed  CAS  Google Scholar 

  38. H. Moreau, R. Laugier, Y. Gargouri, F. Ferrato, and R. Verger, Human preduoudenal lipase is entirely of gastric fundic origin, Gasteroenterology. 95 (1988) 1221–1226

    CAS  Google Scholar 

  39. C. Salzman-Mann, M. Hamosh, K.N. Sivasubramanian, A. Bar-Maor, O. Zinder, G.B. Avery, J.B. Watkins, and P. Hamosh, Congenital esophageal atresia: lipase activity is present in the esophageal pouch and in the stomach, Dig Dis Sci. 27 (1982) 124–128

    Article  PubMed  CAS  Google Scholar 

  40. M. Hamosh, Y.F. Smith, J. Bernbaum, N.R. Mehta, C.S. Fink, C.M. York, et al.., Fat digestion in premature infants: effect of mode of feeding on lipase activity in the stomach,. In: “Physiologic Foundations of Perinatal Care”, L. Stern, W. Oh, and B Friis-Hansen, eds., New York, Elsevier, 75 (1989) 75–84

    Google Scholar 

  41. L.J. Smith, S. Kaminsky, and S.W. D’Souza, Neonatal fat digestion and lingual lipase, Acta Paediatr Scand. 75 (1986) 913–918

    Article  PubMed  CAS  Google Scholar 

  42. M. Hamosh., “Lingual and Gastric Lipases: Their Role in Fat Digestion”, CRC Press, Boca Raton, (1990).

    Google Scholar 

  43. M. Hamosh, Gastric and lingual lipases, in “Physiology of the gastrointestinal tract” 3rd edition, L.R. Johnson, D.H. Alpers, J. Christensen, E.D. Jacobson, and J.H. Walsh, eds. Raven Press, New York. In Press (1993).

    Google Scholar 

  44. Y. Gargouri, H. Moreau, and R. Verger, Gastric lipases: biochemical and physiological studies. Biochim Biophys Acta 1006 (1989) 255–271.

    Article  PubMed  CAS  Google Scholar 

  45. J. Bitman, D.L. Wood, T.H. Liao, C.S. Fink, P. Hamosh, and M. Hamosh, Gastric lipolysis of milk lipids in suckling rats, Biochim Biophys Acta 834 (1985) 58–64

    Article  PubMed  CAS  Google Scholar 

  46. M. Armand, M. Hamosh, N.R. Mehta, P.A. Angelus, and J.R. Philpott, Gastric lipolysis in premature infants, effects of diet: human milk formula. FASEB J 7 (1993) A201

    Google Scholar 

  47. S.J. Iverson, C.L. Kirk, M. Hamosh, and J. Newsome, Milk lipid digestion in the neonatal dog: The combined actions of gastric and bile salt stimulated lipases, Biochim Biophys Acta 1083 (1991) 109–119

    Article  PubMed  CAS  Google Scholar 

  48. S.J. Iverson, J. Sampugna, and O.T. Oftedal, Positional specificity of gastric hydrolysis of long-chain n-3 polyunsaturated fatty acids of seal milk triglycerides, Lipids 27 (1992) 870–878

    Article  PubMed  CAS  Google Scholar 

  49. S-H. Chiang, J.E. Pettigrew, S.D. Clark and S.G. Cornelius. Digestion and absorption of fish oil by neonatal piglets. JNutr. 119 (1989) 1741–1743

    CAS  Google Scholar 

  50. T.Y. Aw, and M.R. Grigor, Digestion and absorption of triacylglycerol in 14 day old sucking rats, J Nutr. 110 (1980) 2133–2140

    PubMed  CAS  Google Scholar 

  51. A.J.P. Fernando-Warnakulasurija, J.E. Staggers, S.C. Frost, and M.A. Wells, Studies on fat digestion absorption and transport in the suckling rat. I. Fatty acid composition and concentration of major lipid components, J Lipid Res. 22 (1981) 668–674

    Google Scholar 

  52. K.L. Siewert, and D.E. Otterby, Effects of in vivo and in vitro acid environments on the activity of pregastric esterase, J Dairy Sci. 53 (1970) 571–575

    Article  PubMed  CAS  Google Scholar 

  53. M. Hamosh, N.R. Mehta, C.S. Fink, J. Coleman, and P. Hamosh, Fat absorption in premature infants: Medium chain triglycerides and long chained triglycerides are absorbed from formula at similar rates. J Pediatr Gastroenterol Nutr. 13 (1991) 143–149

    Article  PubMed  CAS  Google Scholar 

  54. J. Bitman, D.L. Wood, M. Hamosh, P. Hamosh, and N.R. Mehta, Comparison of the lipid composition of breast milk from mothers of term and preterm infants, Am J Clin Nutr. 38 (1983) 300–312

    PubMed  CAS  Google Scholar 

  55. M. Hamosh, J. Bitman, T.H. Liao, N.R. Mehta, R.J. Buczek, D.L. Wood et al., Gastric lipolysis and fat absorption in preterm infants: effect of MCT or LCT containing formulas, Pediatrics 83 (1989) 86–92

    PubMed  CAS  Google Scholar 

  56. M. Hamosh, S.J. Iverson, C.L. Kirk, and P. Hamosh, Milk lipids and neonatal fat digestion: relationship between fatty acid composition, endogeneous and exogenous digestive enzymes and digestion of milk fat. In “Fatty acids and lipids from cell biology to human disease”, C. Galli, ed. Karger, Basel, In Press (1993).

    Google Scholar 

  57. S.M. Innis, ed. Lipids in infant nutrition. Symposium. J Pediatr. 120 No 4 part 2 (1992)

    Google Scholar 

  58. M.D. Perez, L. Sanchez, P. Aranda, J.M. Ena, R. Oria, and M. Calvo, Effect of ß-lactoglobulin on the activity of pregastric lipase. A possible role for this protein in ruminant milk, Biochim. Biophys. Acta 1123 (1992) 151–155

    Article  PubMed  CAS  Google Scholar 

  59. Institute of Medicine “Nutrition during lactation”, National Academy Press, Washington (1991).

    Google Scholar 

  60. E. Freudenberg, “Die Frauenmilch-Lipase,” S. Karger, Basel, (1953).

    Google Scholar 

  61. L.M. Freed, C.M. York, M. Hamosh, J.A. Sturman, and P. Hamosh, Bile salt-stimulated lipase in non-primate milk: longitudinal variation and lipase characteristics in cat and dog milk, Biochim Biophys Acta 878 (1986) 209–215

    Article  PubMed  CAS  Google Scholar 

  62. L.A. Ellis, and M. Hamosh, Bile salt stimulated lipase: comparative studies in ferret milk and lactating mammary gland, Lipids 27 (1992) 917–922

    Article  PubMed  CAS  Google Scholar 

  63. M. Cohen, G.R.H. Morgan, and A.F. Hofmann, Lipolytic activity of human gastric and duodenal juice against medium and long-chain triglycerides, Gasteroenterology 60 (1971) 1–15

    CAS  Google Scholar 

  64. T.M. Plucinski, M. Hamosh, and P., Hamosh. Fat digestion in the rat: role of lingual lipase, Am J Physiol 237 (1979) E541 - E547

    PubMed  CAS  Google Scholar 

  65. S. Bemback, L. Blackberg, and O. Hernell, The complete digestion of human milk triacylglycerol in vitro requires gastric lipase, pancreatic colipase dependent lipase and bile salt stimulated lipase, J Clin Invest. 85 (1990) 1221–1226

    Article  Google Scholar 

  66. P. Hamosh, and M. Hamosh, Differences in composition of preterm, term and weaning milk. In “New Aspects of Nutrition in Infancy and Prematurity” Xanthou M (ed.) Elsevier, Amsterdam, (1987) 129–141

    Google Scholar 

  67. Kirk CL, and M. Hamosh. Initial lipolysis by gastric lipase is essential for the hydrolysis of milk or formula fat by milk lipase. FASEB J. 5 (1991) Al288

    Google Scholar 

  68. M. Roulet, A.M. Weber, Y. Paradis, C.C. Roy, L. Chartrand, R. Lasalle, et al., Gastric emptying and lingual lipase activity in cystic fibrosis., Pediatr Res. 14 (1980) 1360–1362

    Article  PubMed  CAS  Google Scholar 

  69. J. Moreau, M. Bouisson, D. Balas, A. Kavand, S. Stupnik, L. Buscail, N. Vaysse, and A. Ribert, Gastric lipase in alcoholic pancreatitis, Gastroenterology 99 (1990) 175–180

    PubMed  CAS  Google Scholar 

  70. K. Balasubramanian, P.L. Zentler-Munro, J.C. Batten, and T.C. Northfield, Increased intragastric acid-resistant lipase activity and lipolysis in pancreatic steaton-hea due to cystic fibrosis, Pancreas 7 (1992) 305–310

    Article  PubMed  CAS  Google Scholar 

  71. H. Moreau, J.F. Sauniere, Y. Gargouri, G. Pieroni, and R. Verger, Human gastric lipase: variations induced by gastrointestinal hormones and by pathology, Scand J Gastroenterol.. 23 (1988) 1044–1048

    CAS  Google Scholar 

  72. C.K. Abrams, M. Hamosh, V.S. Hubbard, S.K. Dutta, and P. Hamosh, Lingual lipase in cystic fibrosis. Quantitation of enzyme activity in the upper small intestine of patients with exocrine pancreatic insufficiency, J Clin Invest. 73 (1984) 374–382

    Article  PubMed  CAS  Google Scholar 

  73. C.K. Abrams, M. Hamosh, S.K. Dutta, V.S. Hubbard, and P. Hamosh, The role of non-pancreatic lipolytic activity in exocrine pancreatic insufficiency, Gastroenterology 92 (1987) 125–129

    PubMed  CAS  Google Scholar 

  74. B. Fredrikzon, and L. Blackberg, Lingual lipase: an important enzyme in the digestion of dietary lipids in cystic fibrosis? Pediatr Res. 14 (1980) 1387–1390

    Article  PubMed  CAS  Google Scholar 

  75. T. Lam, S.B. Benjamin, J. Gallagher, M. Bertagnolli, C. Kirk, L. Ellis, M. Hamosh, and P. Hamosh, Gastric digestive enzyme activity is not affected by Helicobacter pylori infection. Gastroenterology 98: A74 (1990).

    Google Scholar 

  76. J.S. DiPalma, C. Kirk, M. Hamosh, A.R. Colon, S.B. Benjamin, and P. Hamosh, Lipase and pepsin activity in the gastric mucosa of children and the role of lipase as a marker for gastrointestinal inflamation. Clin Res. 37 (1989) 367A

    Google Scholar 

  77. N. Scribanu, N.R. Mehta, J.S. DiPalma, and M. Hamosh, Congenital microgastria and hypoplastic upper limb association: histologic confirmation of gastric tissue, J Pediatr. Gastroenterol Nutr. Submitted.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatrics, Georgetown University Medical Center, Washington, DC, 20007, USA

    Margit Hamosh

  2. Department of Physiology and Biophysics, Georgetown University Medical Center, Washington, DC, 20007, USA

    Paul Hamosh

Authors
  1. Margit Hamosh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Paul Hamosh
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Manchester, Manchester, UK

    M. I. Mackness

  2. University of Bordeaux II, Bordeaux, France

    M. Clerc

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer Science+Business Media New York

About this chapter

Cite this chapter

Hamosh, M., Hamosh, P. (1994). Gastric Lipase: Characteristics and Biological Function of Preduodenal Digestive Lipases. In: Mackness, M.I., Clerc, M. (eds) Esterases, Lipases, and Phospholipases. NATO ASI Series, vol 266. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0993-0_17

Download citation

  • DOI: https://doi.org/10.1007/978-1-4899-0993-0_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0995-4

  • Online ISBN: 978-1-4899-0993-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation