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Involvement of the Protein Tyrosine Phosphatase PTP1C in Cellular Physiology, Autoimmunity and Oncogenesis

  • John McCulloch
  • Katherine A. Siminovitch
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 365)

Abstract

Control of a wide range of cellular functions is governed by the phosphorylation of cellular proteins on tyrosine residues. Activities regulated in such a manner include proliferation, differentiation and many specific cellular functions. The phosphorylation status of intracellular proteins is determined by the activity of two mutually antagonistic classes of enzyme — protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs). This article will concentrate on current knowledge concerning the haemopoietic cell phosphatase PTP1C and will describe our recent findings concerning the in vivo and in vitro roles of this protein from PTP1C-mutant mice.

Keywords

Splice Site Haemopoietic Cell Motheaten Mouse Patchy Alopecia Viable Motheaten 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • John McCulloch
    • 1
  • Katherine A. Siminovitch
    • 1
    • 2
  1. 1.Samuel Lunenfeld Research InstituteUniversity of Toronto, Mount Sinai HospitalTorontoCanada
  2. 2.Departments of Medicine and ImmunologyUniversity of Toronto, Mount Sinai HospitalTorontoCanada

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