X-Linked Agammaglobulinemia and Bruton’s Tyrosine Kinase

  • Satoshi Tsukada
  • Owen N. Witte
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 365)


The genetic defect associated with human X-linked agammaglobulinemia (XLA) and murine X-linked immunodeficiency (XID) was recently identified as the deficiency of function of a new cytoplasmic tyrosine kinase called Bruton’s tyrosine kinase (Btk)1,2,3,4. The phenotypes associated with these immunodeficiencies indicate that Btk plays a crucial role in B lymphocyte development.


Unique Region Chromosome Inactivation Tyrosine Kinase Gene Cytoplasmic Tyrosine Kinase Thymus Dependent Antigen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Satoshi Tsukada
    • 1
  • Owen N. Witte
    • 1
  1. 1.Howard Hughes Medical Institute, Department of Microbiology and Molecular GeneticsUniversity of California, Los AngelesLos AngelesUSA

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