Function of the Common β Subunit of the GM-CSF/IL-3/IL-5 Receptors

  • Alice Mui
  • Akihiko Muto
  • Kazuhiro Sakamaki
  • Noriko Sato
  • Taisei Kinoshita
  • Sumiko Watanabe
  • Takashi Yokota
  • Kenichi Arai
  • Atsushi Miyajima
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 365)

Abstract

Interleukin 3 (IL-3) and granulocyte-macrophage colony stimulating factor (GM-CSF) stimulate various lineage-committed cells as well as early multipotential progenitors while interleukin 5 (IL-5) stimulates eosinophils and basophils1. These three cytokines induce similar intracellular signals and exhibit similar functions in their common target cells. Although primary amino acid sequences of IL-3, IL-5 and GM-CSF show no obvious homology, they consist of four α-helices and their gross tertiary structures are similar. Interestingly, binding of a human cytokine to its high affinity receptor is inhibited by another cytokine on their common target cells, e.g. high affinity IL-3 binding to its receptor is inhibited by GM-CSF and vice versa2.

Keywords

Tyrosine Phosphorylation Cytoplasmic Domain High Affinity Receptor Tyrosine Phosphorylated Protein Chimeric Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Alice Mui
    • 1
  • Akihiko Muto
    • 2
  • Kazuhiro Sakamaki
    • 3
  • Noriko Sato
    • 2
  • Taisei Kinoshita
    • 1
  • Sumiko Watanabe
    • 2
  • Takashi Yokota
    • 2
  • Kenichi Arai
    • 2
  • Atsushi Miyajima
    • 1
  1. 1.DNAX Research Institute of Molecular and Cellular BiologyPalo AltoUSA
  2. 2.Institute of Medical ScienceThe University of TokyoTokyo 108Japan
  3. 3.Pharmaceutical Basic Research LaboratoriesJT Inc.Fukuura, Kanazawaku, Yokohama 236Japan

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