Function of the Common β Subunit of the GM-CSF/IL-3/IL-5 Receptors
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Interleukin 3 (IL-3) and granulocyte-macrophage colony stimulating factor (GM-CSF) stimulate various lineage-committed cells as well as early multipotential progenitors while interleukin 5 (IL-5) stimulates eosinophils and basophils1. These three cytokines induce similar intracellular signals and exhibit similar functions in their common target cells. Although primary amino acid sequences of IL-3, IL-5 and GM-CSF show no obvious homology, they consist of four α-helices and their gross tertiary structures are similar. Interestingly, binding of a human cytokine to its high affinity receptor is inhibited by another cytokine on their common target cells, e.g. high affinity IL-3 binding to its receptor is inhibited by GM-CSF and vice versa2.
KeywordsTyrosine Phosphorylation Cytoplasmic Domain High Affinity Receptor Tyrosine Phosphorylated Protein Chimeric Receptor
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