Proximal Signals and the Control of S-Phase Entry in Interleukin-2-Stimulated T Lymphocytes
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Stimulation of resting, G0-phase T lymphocytes with antigenic peptides presented in the context of self-MHC triggers a pleiotropic activation program that culminates in cell-cycle entry and the expression of high-affinity receptors for T-cell-derived growth factors. The principal growth and differentiation factor for antigen-activated T lymphocytes is the T-cell-derived cytokine, interleukin-2 (IL-2). Binding of IL-2 to the high-affinity IL-2 receptor (IL-2R) drives the progression of activated, G1-phase T cells into S-phase and, ultimately, mitosis. The intracellular pathways through which IL-2R occupancy provokes this cell-cycle progression response remains an area of intense interest in the field of T-cell biology.
KeywordsTyrosine Phosphorylation High Molecular Weight Complex Proximal Signal Mitogenic Signal Transduction Tyrosine Phosphorylation Signal
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- 3.M.W. Kirschner, The biochemical nature of the cell cycle, in: “Important Advances in Oncology,” V.T. DeVita, Jr., S. Hellman, and S.A. Rosenberg, eds., J.B. Lippincott Co., Philadelphia (1992).Google Scholar
- 21.N.H. Sigal and F.J. Dumont, Cyclosporin A, FK-506, and rapamycin: Pharmacologic probes of lymphocytes signal transduction, in: “Annual Review of Immunology,” W.E. Paul, ed., Annual Reviews, Inc., Palo Alto (1992).Google Scholar