Fc Receptor Signaling
Immune complex cross-linking of cell surface receptors for immunoglobulin (Ig) triggers pleiotropic cellular events that underpin a wide variety of immune responses. In this fashion receptors for immunoglobulin form a molecular bridge between the humoral and cellular immune responses. Elucidation of the primary structure of receptors for the Fc domain of Ig (FcγRs) has provided invaluable insight into their contribution to immune cell regulation. This revelation has been made possible as the result of cloning of both cDNAs and genes that encode this diverse family of molecules. Over the past decade a nearly complete “dissection” of the molecules that mediate this binding of immune complexes to cells has been accomplished. Current efforts focus on putting these pieces back into an organismic context and determining their roles in systemic processes such as inflammation, autoimmunity, allergy and development. The genetic map of most FcγRs will soon be complete providing a valuable tool to evaluating involvement of these genes in karyotypic instability and landmarks in the search for linked human genes/conditions.
KeywordsMast Cell Cytoplasmic Tail Antibody Dependent Cellular Cytotoxicity Gamma Subunit Passive Cutaneous Anaphylaxis Reaction
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