Quantitative Aspects of Receptor Aggregation

  • Henry Metzger
  • Byron Goldstein
  • Ute Kent
  • Su-Yau Mao
  • Clara Pribluda
  • Victor Pribluda
  • Carla Wofsy
  • Toshiyuki Yamashita
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 365)


The critical role aggregation plays in antibody-mediated activation of cellular responses is now familiar to immunologists. The experimental evidence that led to that understanding has been recounted on several occasions1,2 and the interpretation of the data has stood up well to the newer findings particularly as they relate to cell receptors. It is likewise well known that aggregation is also a widely used mechanism by systems outside those central to the immune response3. In this brief review we wish to focus on what progress has been made in extending our knowledge about some quantitative aspects of the aggregation mechanism.


Mast Cell Human Growth Hormone Antigen Receptor Receptor Aggregation FceRI Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Henry Metzger
    • 1
  • Byron Goldstein
    • 2
  • Ute Kent
    • 1
  • Su-Yau Mao
    • 1
  • Clara Pribluda
    • 1
  • Victor Pribluda
    • 1
  • Carla Wofsy
    • 3
  • Toshiyuki Yamashita
    • 1
  1. 1.Arthritis & Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin DiseasesNational Institutes of HealthBethesdaUSA
  2. 2.Theoretical Biology and BiophysicsLos Alamos National LaboratoryLos AlamosUSA
  3. 3.Department of Mathematics and StatisticsUniversity of New MexicoAlbuquerqueUSA

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