Specific CD45 Isoforms Regulate T Cell Ontogeny and Are Functionally Distinct in Modifying Immune Activation

  • Jamey D. Marth
  • Christopher J. Ong
  • Daniel Chui
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 365)


The antigen receptor complex on the cell surface of T lymphocytes is one of the most modular signal transduction systems yet defined. This characteristic emanates from various mechanisms that promote intermolecular associations between the αβ T cell receptor and the enzymes that transduce the intracellular biological signal cascade (reviewed in 1). Among the multiple proteins that regulate cellular responses following T cell receptor (TCR) stimulation, the CD45 tyrosine phosphatase is a crucial effector. T lymphocytes that lack CD45 expression at the cell surface are unable to transmit immunologic activation signals that initiate from TCR interaction with antigen and major histocompatibility (MHC) molecules (2).


PTPase Activity CD45 Exon Thymocyte Subpopulation CD45 Transgenic Mouse CD45 Tyrosine Phosphatase 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Jamey D. Marth
    • 1
  • Christopher J. Ong
    • 1
  • Daniel Chui
    • 1
  1. 1.The Biomedical Research Centre and the Department of Medical Genetics, 2222 Health Sciences MallUniversity of British ColumbiaVancouverCanada

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