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Specific CD45 Isoforms Regulate T Cell Ontogeny and Are Functionally Distinct in Modifying Immune Activation

  • Chapter
Mechanisms of Lymphocyte Activation and Immune Regulation V

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 365))

Abstract

The antigen receptor complex on the cell surface of T lymphocytes is one of the most modular signal transduction systems yet defined. This characteristic emanates from various mechanisms that promote intermolecular associations between the αβ T cell receptor and the enzymes that transduce the intracellular biological signal cascade (reviewed in 1). Among the multiple proteins that regulate cellular responses following T cell receptor (TCR) stimulation, the CD45 tyrosine phosphatase is a crucial effector. T lymphocytes that lack CD45 expression at the cell surface are unable to transmit immunologic activation signals that initiate from TCR interaction with antigen and major histocompatibility (MHC) molecules (2).

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  1. The Biomedical Research Centre and the Department of Medical Genetics, 2222 Health Sciences Mall, University of British Columbia, Vancouver, B.C., V6T 1Z3, Canada

    Jamey D. Marth, Christopher J. Ong & Daniel Chui

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  2. Christopher J. Ong
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Editors and Affiliations

  1. Department of Medicine, University of California, Irvine, CA, 92717-4069, USA

    Sudhir Gupta

  2. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20892-0001, USA

    William E. Paul

  3. Department of Microbiology and Immunology, University of California, San Francisco, CA, 94143-0552, USA

    Anthony DeFranco

  4. Department of Immunology, University of Washington, Seattle, WA, 98915, USA

    Roger M. Perlmutter

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Marth, J.D., Ong, C.J., Chui, D. (1994). Specific CD45 Isoforms Regulate T Cell Ontogeny and Are Functionally Distinct in Modifying Immune Activation. In: Gupta, S., Paul, W.E., DeFranco, A., Perlmutter, R.M. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation V. Advances in Experimental Medicine and Biology, vol 365. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0987-9_16

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  • DOI: https://doi.org/10.1007/978-1-4899-0987-9_16

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