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Mechanisms of Lymphocyte Activation and Immune Regulation V pp 121–130Cite as

Control of Lymphopoiesis by Non-Receptor Protein Tyrosine Kinases

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 365))

Abstract

Maintenance of a satisfactory immune system requires the daily generation of millions of lymphocytes from immature progenitor cells that reside (in adult mammals) in the bone marrow. Three fundamental processes underlie lymphopoiesis. First, a small population of hematopoietic stem cells (estimated to represent something less than 0.1% of bone marrow cells) gives rise continuously to mature daughter cells through successive, self-regenerating cell divisions (see ref. 1 for a review of hematopoietic stem cells). Second, cells committed to the lymphoid lineages must colonize specialized stromal cell environments wherein extrinsic cues are provided that direct maturation. The maturation of B cell precursors occurs in mammalian bone marrow and can be observed using in vitro culture systems containing well-characterized bone marrow-derived stromal cells (2). Similarly, T lymphocyte maturation, which for conventional T cells takes place in the thymus, can be modelled in vitro or in fetal thymic organ culture (3). Detailed analysis of T and B cell development has established that precursor cells proceed through a series of clearly defined maturation steps, giving rise to intermediate cell populations that display characteristic cell surface molecules. Thus the third fundamental process underlying lymphopoiesis is the regulated maturation of committed progenitors through discrete developmental checkpoints.

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Authors and Affiliations

  1. Howard Hughes Medical Institute and the Department of Immunology, University of Washington, Seattle, WA, 98195, USA

    Roger M. Perlmutter & Steven J. Anderson

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  1. Roger M. Perlmutter
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  2. Steven J. Anderson
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Editors and Affiliations

  1. Department of Medicine, University of California, Irvine, CA, 92717-4069, USA

    Sudhir Gupta

  2. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20892-0001, USA

    William E. Paul

  3. Department of Microbiology and Immunology, University of California, San Francisco, CA, 94143-0552, USA

    Anthony DeFranco

  4. Department of Immunology, University of Washington, Seattle, WA, 98915, USA

    Roger M. Perlmutter

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© 1994 Springer Science+Business Media New York

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Perlmutter, R.M., Anderson, S.J. (1994). Control of Lymphopoiesis by Non-Receptor Protein Tyrosine Kinases. In: Gupta, S., Paul, W.E., DeFranco, A., Perlmutter, R.M. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation V. Advances in Experimental Medicine and Biology, vol 365. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0987-9_13

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  • DOI: https://doi.org/10.1007/978-1-4899-0987-9_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0989-3

  • Online ISBN: 978-1-4899-0987-9

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