Control of Lymphopoiesis by Non-Receptor Protein Tyrosine Kinases

  • Roger M. Perlmutter
  • Steven J. Anderson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 365)


Maintenance of a satisfactory immune system requires the daily generation of millions of lymphocytes from immature progenitor cells that reside (in adult mammals) in the bone marrow. Three fundamental processes underlie lymphopoiesis. First, a small population of hematopoietic stem cells (estimated to represent something less than 0.1% of bone marrow cells) gives rise continuously to mature daughter cells through successive, self-regenerating cell divisions (see ref. 1 for a review of hematopoietic stem cells). Second, cells committed to the lymphoid lineages must colonize specialized stromal cell environments wherein extrinsic cues are provided that direct maturation. The maturation of B cell precursors occurs in mammalian bone marrow and can be observed using in vitro culture systems containing well-characterized bone marrow-derived stromal cells (2). Similarly, T lymphocyte maturation, which for conventional T cells takes place in the thymus, can be modelled in vitro or in fetal thymic organ culture (3). Detailed analysis of T and B cell development has established that precursor cells proceed through a series of clearly defined maturation steps, giving rise to intermediate cell populations that display characteristic cell surface molecules. Thus the third fundamental process underlying lymphopoiesis is the regulated maturation of committed progenitors through discrete developmental checkpoints.


Cell Receptor Antigen Receptor Cell Antigen Receptor Thymocyte Development Allelic Exclusion 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Roger M. Perlmutter
    • 1
  • Steven J. Anderson
    • 1
  1. 1.Howard Hughes Medical Institute and the Department of ImmunologyUniversity of WashingtonSeattleUSA

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