Nonreceptor Tyrosine Kinases in Aggregation-Mediated Cell Activation

  • Brian Seed
  • Waldemar Kolanus
  • Charles Romeo
  • Ramnik Xavier
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 365)


Many of the cellular recognition events in the immune system which are mediated by cell surface receptors are initiated by cell-cell contacts which result in receptor aggregation. Almost universally, the relevant receptors lack intrinsic enzymatic activity. However a growing body of evidence suggests that tyrosine phosphorylation is an early concomitant of cellular activation initiated by aggregation of cell surface receptors, and in some cases a causal role for tyrosine kinases in the activation process can be identified.


Tyrosine Phosphorylation Antigen Receptor Nonreceptor Tyrosine Kinase Cell Antigen Receptor Zeta Chain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Brian Seed
    • 1
  • Waldemar Kolanus
    • 1
  • Charles Romeo
    • 1
  • Ramnik Xavier
    • 1
  1. 1.Department of Molecular BiologyMassachusetts General HospitalBostonUSA

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