The Role of Syk in Cell Signaling

  • Robert L. Geahlen
  • Debra L. Burg
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 365)

Abstract

Many multichain antigen receptors on the surfaces of immune cells signal by stimulating the phosphorylation of key intracellular proteins on tyrosine. This occurs even though the transmembrane components of the receptors themselves lack intrinsic enzymic activity. Instead, these receptors associate with and signal through cytoplasmic proteintyrosine kinases. These kinases are now known to include members of a new family of proteins for which the prototype is a recently discovered enzyme known as p72 syk .

Keywords

Antigen Receptor Cell Antigen Receptor Murine Spleen Antigen Receptor Complex Molecular Weight Precursor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Robert L. Geahlen
    • 1
  • Debra L. Burg
    • 1
  1. 1.Department of Medicinal ChemistryPurdue UniversityWest LafayetteUSA

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