Abstract
The proline utilisation pathway is one of the most appropriate examples of control of gene expression in Aspergillus nidulans and indeed in the fungi in general. The study of this pathway permits one to investigate the mechanism of specific induction, the interaction of carbon catabolite and nitrogen metabolite repression and provides interesting hints as to the function of gene clustering in eukaryotic microorganisms.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Arst, H. N. Jr. and Cove, D. J. (1973) Nitrogen metabolite repression in Aspergillus nidulans. Mol. Gen. Genet. 126, 111–141.
Arst, H. N. Jr. and MacDonald, D. W. (1975). A gene cluster of Aspergillus nidulans with an internally located cis-actin regulatory region. Nature 254, 26–31.
Arst, H. N. Jr. and MacDonald, D. W. (1978) Reduced expression of a distal gene of the prn gene cluster in deletion mutants of Aspergillus nidulans: genetic evidence for a dicistronic messenger in a eukaryote. Mol. Gen. Genet. 163, 7–22.
Arst, H. N. Jr. and Scazzocchio, C. (1975) Initiator constitutive mutation with an “up promoter effect” in Aspergillus nidulans. Nature 254, 31–34.
Arst, H. N. Jr., MacDonald, D. W. and Jones, S. A. (1980) Regulation of proline transport in Aspergillus nidulans. J. Gen. Microbiol. 116, 285–294.
Arst, H. N. Jr., Jones, S. A. and Bailey, C. R. (1981) A method for selection of deletion mutations in the L-proline catabolism gene cluster of Aspergillus nidulans. Genet. Res. Camb. 38, 171–195.
Bailey, C. R. and Arst, H. N. Jr. (1975) Carbon catabolite repression in Aspergillus nidulans. Eur. J. Biochem. 51, 573–577.
Brandriss, M. C. and Magasanik, B. (1981) Subcellular compartementation in the control of converging pathways for proline and arginine metabolism in Saccharomyces cerevisiœ. J. Bact. 145, 1359–1364.
Burger, G., Strauss, J., Scazzocchio, C. and Lang, F. B. (1991) nirA, the pathway-specific regulatory gene of nitrate assimilation in Aspergillus nidulans, encodes a putative GAL-4 type zinc finger protein and contains four introns in highly conserved regions. Mol. Cel. Biol. 11, 5746–5755.
Dowzer, C. E. A. and Kelly, J. (1991) Analysis of the creA gene, a regulator of carbon catabolite repression in Aspergillus nidulans. Mol. Cell. Biol. 11, 5701–5709.
Fidel, S., Doonan, J. H. and Morris, N. R. (1988) Aspergillus nidulans contains a single actin gene which has unique intron locations and encodes a g-actin. Gene 70, 283–293.
Fu, Y-H. and Marzluf, G. A. (1990) nit-2, the major positive-acting nitrogen regulatory gene of Neurospora crassa, encodes a sequence-specific DNA-binding protein. Proc. Natl. Acad. Sci. 87, 5331–5335.
Gavrias, V. (1992) Etudes moleculaires sur la régulation et la structure du groupe des gènes prn chez Aspergillus nidulans. Doctoral Thesis, Unversité Paris-Sud (XI) Orsay.
Green, P. M. and Scazzocchio C. (1985) A cloning strategy in filamentous fungi, in “Gene Manipulations in Fungi” pp. 345–353. Bennett, J. W. and Lasure, L. L. Eds. Academic Press, Orlando.
Gorfinkiel, L., Diallinas, G. and Scazzocchio C. (1993) Sequence and regulation of the uapA gene, encoding a uric acid-xanthine permease in the fungus Aspergillus nidulans. J. Biol. Chem. In press.
Hull, E. P. (1988) Molecular Analysis of the proline catabolism gene cluster of Aspergillus nidulans and sequencing of the regulatory gene. Ph. D. Thesis, Univesity of Essex, Cochester.
Hull, E. P., Green, P. M. , Arst, H. N. Jr and Scazzocchio, C. (1989) Cloning and physical characterization of the L-proline catabolism gene cluster of Aspergillus nidulans. Mol. Microbiol. 3, 553–559.
Hynes, M. J. (1975) Studies on the role of the areA gene in the regulation of nitrogen catabolism in Aspergillus nidulans. Aust. J. Biol. Sci. 28, 301–313.
Jones, S. A., Arst H. N. Jr. and MacDonald D. W. (1981) Genes roles in prn cluster of Aspergillus nidulans. Curr. Genet. 3, 49–56.
Kulmburg, P., Prangé, T., Mathieu, M., Sequeval, D., Scazzocchio, C. and Felenbok, B. (1990) Correct intron splicing generates a new type of a putative Zn-finger domain in a transcriptional activator of Aspergillus nidulans. FEBS Letter 280, 11–16.
Kulmburg, P., Mathieu, M., Dowzer, C., Kelly, J. and Felenbok, B. (1993) Specific binding sites in the alcR and alcA promoters of the ethanol regulon for the CREA repressor mediating carbon catabolite repression in Aspergillus nidulans. Mol. Micobiol. 7, 847–857.
Kudla, B., Caddick M. X., Langdon T., Martinez-Rossi N. C., Bennet C. F., Sibley S., Davies R. W. and Arst H. N. Jr. (1990) The regulatory gene areA mediating nitrogen metabolite repression in Aspergillus nidulans. Mutations affecting specifity of gene activation alter a loop residue of a putative zinc finger. EMBO J. 9, 1355–1364.
Lockington, R. A, Scazzocchio, C., Sequeval D, Mathieu, M, and Felenbok, B. (1987) Regulation of alcR, the positive regulatory gene of the ethanol utilization regulon of Aspergillus nidulans. Mol. Microbiol. 1, 275–281.
Oestreicher, N. and Scazzocchio, C. (1993) Sequence, regulation and mutational analysis of the gene encoding urate oxidase in Aspergillus nidulans. J. Biol. Chem. In press.
Pavletich, N. and Pabo, C. O. (1991) Zinc finger-DNA recognition: Crystal tructure of the Zif268-DNA complex at 2.1 Å. Science 252, 809–817.
Scazzocchio, C. (1990) Of moulds and men, or two fingers are not better than one. Trends in Genet 6, 311–313.
Sharma, K. K. and Arst, H. N. Jr. (1985) The product of the regulatory gene of the proline catabolism gene cluster in Aspergillus nidulans is a positive acting protein. Curr. Genet. 9, 299–304.
Sophianopoulou, V. and Scazzocchio, C. (1989) The proline transport protein of Aspergillus nidulans is very similar to amino acid transporters of Saccharomyces cerevisiae. Mol. Microbiol. 3, 705–714.
Sophianopoulou, V., Suárez, T., Diallinas, G. and Scazzocchio, C. (1993) Operator derepressed mutations in the proline utilisation gene cluster of Aspergillus nidulans. Mol. Gen. Genet. 236, 209–213.
Stankovich, M., Platt, A., Caddick, M. X., Langdon, T., Shaffer, P. M. and Arst, H. N. Jr. (1993) C-terminal truncation of the transcriptional activator encoded by areA in Aspergillus nidulans results in both loss-of-function and gain- of-function phenotypes. Mol. Microbiol. 7, 81–88.
Suárez, T., Oestreicher, N., Peñalva, M. A. and Scazzocchio C. (1991) Molecular cloning of the uaY regulatory gene of Aspergillus nidulans reveals a favoured region for DNA insertions. Mol. Gen. Genet. 230, 369–375.
Tollervey, D. W. and Arst, H. N. Jr. (1975) Mutations to constitutivity and derepression are separate and separable in a regulatory gene of Aspergillus nidulans. Curr. Genet. 6, 79–85.
Vandenbol, M., Jaumiaux, J. C. and Grenson, M. (1989) Nucleotide sequence of the Saccharomyces cerevisiœ PUT4 proline permease-encoding gene: similarities between CAN1, HIP1 and PUT4 permeases. Gene 83, 153–159.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1994 Springer Science+Business Media New York
About this chapter
Cite this chapter
Gavrias, V., Cubero, B., Cazelle, B., Sophianopoulou, V., Scazzocchio, C. (1994). The Proline Utilisation Gene Cluster of Aspergillus Nidulans . In: Powell, K.A., Renwick, A., Peberdy, J.F. (eds) The Genus Aspergillus . Federation of European Microbiological Societies Symposium Series, vol 69. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0981-7_16
Download citation
DOI: https://doi.org/10.1007/978-1-4899-0981-7_16
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-0983-1
Online ISBN: 978-1-4899-0981-7
eBook Packages: Springer Book Archive