Pathogenesis and Virulence of Pasteurella Haemolytica in Cattle: An Analysis of Current Knowledge and Future Approaches

  • A. W. Confer
  • K. D. Clinkenbeard
  • G. L. Murphy


Pasteurella haemolytica is the cause of a severe fibrinous pleuropneumonia of cattle termed Shipping Fever (Frank, 1989). Serovar Al is isolated most often from bovine pneumonic pasteurellosis. The pathogenesis of pneumonic pasteurellosis relies on several bacterial-host interactions: nasopharyngeal colonization, inhalation, pulmonary alveolar colonization, host response to colonization, and bacterial evasion of host defense (Whiteley et al., 1992).


Virulence Factor Alveolar Macrophage Arachidonic Acid Metabolite Nasal Mucus Pulmonary Alveolus 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • A. W. Confer
    • 1
  • K. D. Clinkenbeard
    • 1
  • G. L. Murphy
    • 1
  1. 1.Department of Veterinary PathologyCollege of Veterinary Medicine Oklahoma State UniversityStillwaterUSA

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