Critique of the Guidance Document and Guidelines for the Conduct of Field Studies to Evaluate the Exposure of Operators, Workers, and Bystanders
Concerns about chronic risks from pesticide exposure have increased in part driven by more complete toxicology databases and an increasingly wary public1. Risk assessments targeted at the most sensitive species at the lowest NOEL instead of mitigating acute adverse effects observable in humans under normal work conditions have fueled the need for more accurate estimates of worker exposure. A high percentage of new pesticides and an even higher percentage of “older” pesticides do not meet the acceptable risk criteria when the very conservative default exposure estimates of generic (Tier 1) studies are applied. The process of quantitative risk assessment has required scientists that monitor pesticide exposure to workers to determine delivered (absorbed) dosage. We have evolved from an industrial hygiene perspective where the work environment was monitored for ambient levels to the need to quantitate the absorbed dosage where workers themselves are monitored. The industrial hygiene measurements are still extremely valuable to evaluate environmental conditions that contribute to exposure, but these measurements frequently do not meet the demands of modern risk assessment to determine absorbed dose.
KeywordsExposure Assessment Pesticide Exposure Dermal Absorption Mercapturic Acid Quantitative Risk Assessment
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