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Ovulation as a Tissue Remodelling Process

Proteolysis and Cumulus Expansion

  • Chapter
Tissue Renin-Angiotensin Systems

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 377))

Summary

Ovulation, recurring every midcycle of the mammalian female and triggered by a surge of luteinizing hormone (LH) released from the pituitary, is an essential prerequisite for fertilization and subsequent embryonic development. Here we shall describe two of the biological components of the ovulatory response, cumulus expansion (frequently denoted as cumulus maturation) and the rupture of follicular wall, both crucial for the release of a fertilizable ovum. The role of a proteolytic cascade and its regulation by eicosanoids will be emphasized in relation to follicle rupture. The new data implicating cumulus maturation as an essential step for the release of the ovum and the apparent mediatory role of interleukin-1 in this process will be presented.

LH/hCG stimulates, in the preovulatory follicles, a cascade of proteolytic enzymes, including plasminogen activator (PA), plasmin and matrix metalloproteinase 1 (MMP-1). These enzymes bring about the degradation of perifollicular matrix and, most notably, the decomposition of the meshwork of collagen fibers which provides the strength to follicular wall. Furthermore, pharmacological blockage of any of these enzymes resulted in inhibition of follicle rupture.

LH/hCG stimulates, in addition, an increase in ovarian production of eicosanoids. These include prostaglandins, obtained from arachidonic acid via the cyclooxygenase pathway and leukotrienes, the products of lipoxygenase. Previous studies from our and other laboratories have demonstrated the ability of inhibitors of cyclooxygenase and of lipoxygenases to suppress ovulation in several mammalian species. MK-886, which inhibits the translocation of 5-lipoxygenase (5-LO) from the cytosol and its binding to the membranal 5-LO activating enzyme, suppressed dose-dependently follicular rupture from the treated ovary. Zymographic analysis of ovarian extracts from PMSG/hCG-stimulated rats revealed a band of collagenolytic activity at 52kD, corresponding to human MMP-1 and at 72kD, corresponding to human MMP-2. Both activities were markedly stimulated by administration of hCG and were significantly inhibited by indomethacin, NDGA or MK-886. Thus, eicosanoids seem to mediate LH stimulation of follicular collagenase.

Interleukin-1 (IL-1) has been recently implicated in ovulation. The ability of an IL-1 receptor antagonist (ra) to block ovulation in vivo and in vitro has been demonstrated recently. Morphological examination of the ovulatory follicles failing to ovulate suggests that this effect is exerted by inhibiting cumulus oophorus expansion and detachment from mural granulosa cells. In vitro, IL-1ra attenuated the action of hCG and FSH on cumulus expansion and follicular hyaluronic acid synthesis. Thus, IL-1 seems to mediate and/or facilitate gonadotropin action on cumulus expansion, and hence on ovulation.

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References

  • Abisogun AO, Daphna-Iken D, Reich R, Kranzfelder D, Tsafriri A. Modulatory role of eicosanoids in vascular changes during the preovulatory period in the rat. Biol Reprod 1988; 38: 756–762.

    Article  PubMed  CAS  Google Scholar 

  • Abisogun AO, Braquet P, Tsafriri A. The involvement of platelet activating factor in ovulation. Science 1989; 243: 381–383.

    Article  PubMed  CAS  Google Scholar 

  • Adashi AY, Kokia E, Hurwitz A. Potential relevance of cytokines to ovarian physiology. In: Findlay JK, ed. Molecular Biology of the Female Reproductive System. Academic Press, San Diego, 1994: 83–99).

    Chapter  Google Scholar 

  • Ahrén K, Janson PO, Selstam G. A technique for perfusion of rabbit ovaries in vitro. Methods Enzymol 1975; 39: 1–9.

    Google Scholar 

  • Ainsworth L, Baker RD, Armstrong DT. Preovulatory changes in follicular fluid prostaglandin F levels in swine. Prostaglandins 1975; 9: 915–925.

    PubMed  CAS  Google Scholar 

  • Ainsworth L, Tsang BH, Marcus GJ, Downey BR. Prostaglandin production by dispersed granulosa and theca interna cells from porcine preovulatory follicles. Biol Reprod 1984; 31: 115–121.

    Article  PubMed  CAS  Google Scholar 

  • Akazawa K, Matsuo O, Kosugi T, Mihara H, Mori N. The role of plasminogen activator in ovulation. Acta Physiol. Latino America 1983a; 33, 105–110.

    CAS  Google Scholar 

  • Akazawa K, Mori N, Kosogi T, Matsuo O, Mihara H. Localization of fibrinolytic activity in ovulation of the rat follicle as determined by the fibrin slide method. Japanese J Physiol 1983b; 33:1011–1018.

    Article  CAS  Google Scholar 

  • Alexander BM, Van Kirk EA, Murdoch WJ. Secretion of platelet-activating factor by periovulatory ovine follicles. Life Sciences 1990; 47: 865–868.

    Article  PubMed  CAS  Google Scholar 

  • Alexander CM, Werb Z. Proteinases and extracellular matrix remodeling. Current Opinion in Cell Biology 1989; 1: 974–982.

    Article  PubMed  CAS  Google Scholar 

  • Amiel ML, Testart J, Benveniste J. Platelet-activating factor-αcether is a component of human follicular fluid. Fertil Steril 1991; 56: 62–65.

    PubMed  CAS  Google Scholar 

  • Amsterdam A. Lindner HR, Groschel-Stewart V. Localization of actin and myosin in the rat oocyte and follicular wall by immunofluorescence. Anat Rec 1997; 187: 311–328.

    Google Scholar 

  • Armstrong DT, Grinwich DL. Blockade of spontaneous and LH-induced ovulation in rats by indomethacin an inhibitor of prostaglandin biosynthesis. Prostaglandins 1972; 1: 21–28.

    PubMed  CAS  Google Scholar 

  • Armstrong DT, Grinwich DL, Moon YS, Zamecnik J. Inhibition of ovulation in rabbits by intrafollicular injection of indomethacin and PGF2α antiserum. Life Sci. 1974; 14: 129–140.

    Article  PubMed  CAS  Google Scholar 

  • Armstrong DT, Zamecnik J. Preovulatory elevation of rat ovarian prostaglandin F and its blockade by indomethacin. Mol Cell Endocrinol 1975; 2: 125–131.

    Article  PubMed  CAS  Google Scholar 

  • Barak V, Mordel N, Hölzer H, Zajicek G, Treves AJ, Laufer N. The correlation of interleukin-1 and tumor necrosis factor to estradiol progesterone and testosterone levels in periovulatory follicular fluid of in-vitro fertilization patients. Hum Reprod 1992; 7: 462–464.

    PubMed  CAS  Google Scholar 

  • Bauminger S, Lindner HR. Periovulatory changes in ovarian prostaglandin formation and their hormonal control in the rat. Prostaglandins 1975; 9: 737–751.

    PubMed  CAS  Google Scholar 

  • Bauminger S, Lieberman ME, Lindner HR. Steroid-independent effect in gonadotropins on prostaglandin synthesis in rat Graafian follicles in vitro. Prostaglandins 1975; 9: 753–764.

    PubMed  CAS  Google Scholar 

  • Beers WH. Follicular plasminogen and plasminogen activator and the effect of plasmin on ovarian follicular wall. Cell 1975; 6: 379–386.

    Article  PubMed  CAS  Google Scholar 

  • Beers WH, Strickland S. A cell culture assay for follicle-stimulating hormone. J Biol Chem 1978; 253: 3877–3881.

    PubMed  CAS  Google Scholar 

  • Beers WH, Strickland S, Reich E. Ovarian plasminogen activator: Relationship to ovulation and hormonal regulation. Cell 1975; 6: 387–394.

    Article  PubMed  CAS  Google Scholar 

  • Bjersing L, Cajander S. Ovulation and the mechanism of follicular rupture. VI. Ultrastructure of theca interna and the inner vascular network surrounding rabbit Graafian follicles prior to induced ovulation. Cell and Tissue Res 1974; 153: 31–44.

    CAS  Google Scholar 

  • Blandau RJ, Rumery RE. Measurements of intrafollicular pressure in ovulatory and preovulatory follicles of rat. Fertil Steril 1963; 14: 330–341.

    PubMed  CAS  Google Scholar 

  • Brännström M. Inhibitory effect of mifepristone (RU 486) in the isolated perfused rat ovary. Contraception 1993; 48: 393–399.

    Article  PubMed  Google Scholar 

  • Brännström M, Hellberg P. Bradykinin potentiates LH-induced follicular rupture in the rat ovary perfused in vitro. Human Reprod 1989; 4: 475–481.

    Google Scholar 

  • Brännström M, Janson PO. Progesterone is a mediator in the ovulatory process in the in vitro perfused rat ovary. Biol Reprod 1989; 40: 1170–1177.

    Article  PubMed  Google Scholar 

  • Brännström M, Woessner JF, Koos RD, Sear CHJ, LeMaire WJ. Inhibitors of mammalian tissue collagenase and metaloproteinases suppress ovulation in the perfused rat ovary. Endocrinology 1988; 122: 1715–1721.

    Article  PubMed  Google Scholar 

  • Brännström M, Larson L, Basta B, Hedin L. Regulation of prostaglandin endoperoxide synthase by cyclic adenosine 3′5′-monophosphate in the in vitro-perfused rat ovary. Biol Reprod 1989; 41: 513–522.

    Article  PubMed  Google Scholar 

  • Brännström M, Mayrhofer G, Robertson S. Localization of leukocyte subsets in the rat ovary during the periovulatory period. Biol Reprod 1993a; 48:277–286.

    Article  PubMed  Google Scholar 

  • Brännström M, Wang L, Norman RJ, Ovulatory effects of interleukin-1β on the perfused rat ovary. Endocrinology 1993b; 132:399–404.

    Article  PubMed  Google Scholar 

  • Brännström M, Norman RJ, Seamark RF, Robertson SA. Rat ovary produces cytokines during ovulation. Biol Reprod 1994; 50: 88–94.

    Article  PubMed  Google Scholar 

  • Braquet P, Spinnewyn B, Braquet M, Bourgain RH. Taylor JE, Etienne A, Drien K. BN 52021 and related compounds: A new series of highly specific PAF-acether receptor antagonists isolated from Ginkgo biloba. Bloodvessels 1985; 16: 559–572.

    Google Scholar 

  • Bronson RA, Bryant G, Balk M, Emanuele N. Intrafollicular pressure within preovulatory follicles of the pig. Fertil Steril 1979; 31: 205–213.

    PubMed  CAS  Google Scholar 

  • Bullock W, Kappauf BH. Dissociation of gonadotropin-induced ovulation and steroidogenesis in immature rats. Endocrinology 1972; 92: 1625–1628.

    Article  Google Scholar 

  • Burden HW, Lawrence IE. Nerve supply of the ovary. In: Motta PM, Hafez ESE, eds. Biology of the Ovary, The Hague Martinus, Nijhoff, 1980: 99–105.

    Chapter  Google Scholar 

  • Canipari R, O’Connell ML, Meyer G, Strickland S. Mouse ovarian granulosa cells produce urokinase-type plasminogen activator whereas the corresponding rat cells produce tissue-type plasminogen activator. J Cell Biol 1987; 205: 977–981.

    Article  Google Scholar 

  • Carmeliet P, Schoonjans L, Kieckens L, Ream B, Degen J, Bronson R, De Vos R, van den Oord JJ, Collen D, Mulligan RC. Nature 1994; 368: 419–424.

    Article  PubMed  CAS  Google Scholar 

  • Carvalho CB, Yeik BS, Murdoch WJ. Significance of follicular cyclooxygenase and lipoxygenase pathways of metabolism of arachidonate in sheep. Prostaglandins 1989; 37: 553–558.

    PubMed  CAS  Google Scholar 

  • Cavender JL, Murdoch WJ. Morphological studies of the microcirculatory system of periovulatory ovine follicles. Biol Reprod 1988; 39: 989–997.

    Article  PubMed  CAS  Google Scholar 

  • Chen L, Russell PT, Larsen WJ. Functional significance of cumulus expansionin the mouse: roles for the preovulatory synthesis of hyaluronic acid within the cumulus mass. Mol. Reprod Develop 1993; 34: 87–93.

    Article  CAS  Google Scholar 

  • Chun S-Y, Popliker M, Reich R, Tsafriri A. Localization of preovulatory expression of plasminogen activator inhibitor type-1 and tissue inhibitor of metalloproteinase type-1 in the rat ovary. Biol Reprod 1992; 47: 245–253.

    Article  PubMed  CAS  Google Scholar 

  • Chun S-Y, Daphna-Iken D, Caiman D, Tsafriri A. Severe leukocyte depletion does not affect follicular rupture in the rat. Biol Reprod 1993a; 48: 905–909.

    Article  PubMed  CAS  Google Scholar 

  • Chun S-Y, Reich R, Jarry H, Pitzel L, Wuttke W, Tsafriri A. Localization of interstitial collagenase gene expression in gilt preovulatory follicles. Endocrine Journal 1993b; 1: 481–486.

    Google Scholar 

  • Curry TE, Dean DD, Woessner JF, LeMaire WJ. The extraction of a tissue collagenase associated with ovulation in the rat. Biol Reprod 1985; 33: 981–991.

    Article  PubMed  CAS  Google Scholar 

  • Curry TEJ, Dean DD, Sanders SL, Pedigo NG, Jones PBC. The role of ovarian proteases and their inhibitors in ovulation. Steroids 1989; 54: 501–521.

    Article  PubMed  CAS  Google Scholar 

  • Daphna-Iken D, Chun SY, Abisogun SO, Tsafriri A. Platelet-activating factor ginkgolides and follicle rupture during ovulation. Ginkgolides — Chemistry Biology Pharmacology and Clinical Perspectives 1989; 2: 835–844.

    Google Scholar 

  • Darling MRN, Joyce M, Elder MG. Prostaglandin F2a levels in the human ovarian follicle. Prostaglandins 1982; 23: 551–556.

    PubMed  CAS  Google Scholar 

  • Daud AI, Bumpus FM, Husain A. Angiotensin II: Does it have a direct obligate role in ovulation?Science 1989; 245: 870–871.

    Article  CAS  Google Scholar 

  • de Greef WJ, van der Schoot P. Effects of dexamethasome on ovarian activity in the rat. Acta Endocrinol 1987; 116:350–356.

    PubMed  Google Scholar 

  • Deyerle KL, Sims JE, Dower SK, Bothwell MA Pattern of IL-1 receptor gene expression suggests role in non-inflammatory processes. J Immunol 1992; 149: 1657–1665.

    PubMed  CAS  Google Scholar 

  • Didio LJA, Allen DJ, Correr S, Motta PM. Smooth muscle in the ovary. In: Motta PM, Hafez ESE, eds.) Biology of the Ovary, The Hague Martinus, Nijhoff, 1980; 107–118.

    Google Scholar 

  • Espey LL. Tenacity of porcine Graafian follicle as it approaches ovulation. Am J Physiol 1967a; 212:1397–1401.

    PubMed  CAS  Google Scholar 

  • Espey LL Ultrastructure of the apex of the rabbit Graafian follicle during the ovulatory process. Endocrinology 1967b; 81:267–276.

    Article  PubMed  CAS  Google Scholar 

  • Espey LL. Ovarian proteolytic enzymes and ovulation. Biol Reprod 1974; 10: 216–235.

    Article  PubMed  CAS  Google Scholar 

  • Espey LL. Ovulation. In: Jones RE, ed. The Vertebrate Ovary. Plenum Press, 1978a;503-532.

    Google Scholar 

  • Espey L. Ovarian contractility and its relationship to ovulation: A review. Biol Reprod 1978b; 19: 540–551.

    Article  PubMed  CAS  Google Scholar 

  • Espey LL. Ovulation as an inflammatory reaction — a hypothesis. Biol Reprod 1980; 22: 73–106.

    Article  PubMed  CAS  Google Scholar 

  • Espey LL. The role of steroids in mammalian ovulation. In: Tsafriri A, Dekel N, eds. Follicular Development and the Ovulatory Response, Rome Ares-Serono Symposia, 1989; 23: 189–198.

    Google Scholar 

  • Espey LL. A review of factors that could influence membrane potentials of ovarian follicular cells during mammalian ovulation. Acta Endocrinol 1992; 126: 1–31.

    PubMed  Google Scholar 

  • Espey LL, Lipner H. Measurements of intrafollicular pressures in the rabbit ovary. Am J Physiol 1963; 205: 1067–1072.

    PubMed  CAS  Google Scholar 

  • Espey LL, Lipner H. Enzyme-induced rupture of rabbit Graafian follicle. Am J Physiol 1965; 208: 208–213.

    PubMed  CAS  Google Scholar 

  • Espey LL, Lipner H. The mechanism of ovulation. In: Knobil E., Neill JD, eds. Physiology of Reproduction, 2nd edition, Raven Press, New York, 1993; 1: 725–780.

    Google Scholar 

  • Espey LL, Rondell P. Estimation of mammalian collagenolytic activity with a synthetic substrate. J Appl Physiol 1967; 23 457–461.

    Google Scholar 

  • Espey LL, Stacy S Failure of an ovarian collagenolytic extract to decompose the connective tissue in the mature sow graafian follicle. Fed Proc 1970; 29:833.

    Google Scholar 

  • Espey LL, Miller DH, Margolius HS. Ovarian increase in kinin-generating capacity in PMSG/hG-primed immature rat. Am J Physiol 1986; 251:E361–E365.

    Google Scholar 

  • Espey LL, Tanaka N, Okamura H. Increase in ovarian leukotrienes during hormonally induced ovulation in the rat. Am J Physiol 1989a; 256 E753–E759.

    PubMed  CAS  Google Scholar 

  • Espey LL, Tanaka N, Winn V, Okamura H. Increase in ovarian kallikrein activity during ovulation in the gonadotrophin-primed immature rat. J Reprod Fertil 1989b; 87: 503–508.

    Article  PubMed  CAS  Google Scholar 

  • Espey LL, Tanaka N, Woodard DS, Harper MJK, Okamura H. Decrease in ovarian platelet-activating factor during ovulation in the gonadotropin-primed immature rat. Biol Reprod 1989c; 40: 104–110.

    Article  Google Scholar 

  • Feldman E, Haberman S, Abisogun AO, Reich R, Levran D, Maschiach S, Zuckermann H, Rudak E, Dor J, Tsafriri A. Arachidonic acid metabolism in human granulosa cells: Evidence for cyclooxygenase and lipoxygenase activity in vitro. Hum Reprod 1986; 1: 353–356.

    PubMed  CAS  Google Scholar 

  • Fernandez CA, Tarlatzis BC, Rzasa PJ, Caride VJ, Laufer N, Negro-Vilar AF, DeCherney AH, Naftolin F. Renin-like activity in ovarian follicular fluid. Fertil Steril 1985; 44: 119–222.

    Google Scholar 

  • Fukumoto M, Yajima Y, Okamura H, Midorikawa O. Collagenolytic enzyme activity in human ovary: An ovulatory enzyme system. Fertil Steril 1981; 36: 746–750.

    PubMed  CAS  Google Scholar 

  • Fumagalli Z, Motta P, Calvieri S. The presence of smooth muscular cells in the ovary of several mammals as seen under the electron microscope. Experientia 1971; 27: 82–683.

    Article  Google Scholar 

  • Gao X, Greenbaum LM, Mahesh V, Brann DW. Characterization of the kinin system in the ovary during ovulation in the rat. Biol Reprod 1992; 47: 945–951.

    Article  PubMed  CAS  Google Scholar 

  • Gaytan F, Aceitero J, Bellido C, Sanchez-Criado JE, Aguilar E. Estrous cycle-related changes in mast cell numbers in several ovarian compartments in the rat. Biol Reprod 1991; 45: 27–33.

    Article  PubMed  CAS  Google Scholar 

  • Gelehrter TD, Sznycer-Lascuk R, Zeheb R, Cwikel BJ. Dexamethasone inhibition of tissue-type plasminogen activator (tPA) activity: Paradoxical induction of both tPA antigen and plasminogen activator inhibitor. Mol Endocrinol 1987; 1: 97–101.

    Article  PubMed  CAS  Google Scholar 

  • Goetz FW, Berndtson AK, Ranjan M. Ovulation: mediators at the ovarian level. In: Vertebrate Endocrinology: Fundamentals and Biomedical Implications, 4 Part A Academic Press Inc, 1991; 127-203.

    Google Scholar 

  • Hamada Y, Wright KH, Wallach EE. The effect of progesterone and human chorionic gonadotrophin on ovulation in the in vitro perfused ovary. Fertil Steril 1979; 32: 335–339.

    PubMed  CAS  Google Scholar 

  • Heaton JH, Gelehter TD. Cyclic nucleotide regulation of plasminogen activator-inhibitor messenger RNAs in rat hepatoma cells. Mol Endocrinol 1990; 4: 171–178.

    Article  PubMed  CAS  Google Scholar 

  • Hedin L, Gaddy-Kurten D, Kurten R, De Witt DL, Smith W, Richards JS. Prostaglandin endoperoxide synthase in rat ovarian follicles: Content cellular distribution and evidence for hormonal induction preceding ovulation. Endocrinology 1987; 121: 722–731.

    Article  PubMed  CAS  Google Scholar 

  • Hekman CM, Loskutoff DJ. Bovine plasminogen activator inhibitor 1: Specificity determinations and comparison of the active latent and guanidine-activated forms. Biochem 1988; 27: 2911–2918.

    Article  CAS  Google Scholar 

  • Hellberg P, Holmes PV, Brannstrom M, Olofsson J, Janson PO. Inhibitors of lipoxygenase increase the ovulation rate in the in vitro perfused luteinizing hormone-stimulated rabbit ovary. Acta Physiol Scand 1990; 138 557–564.

    Article  PubMed  CAS  Google Scholar 

  • Hellberg P, Larson L, Olofsson J, Hedin L, Brännström M. Stimulatory effects of bradykinin on the ovulatory process in the in vitro-perfused rat ovary. Biol Reprod 1991a; 44: 269–274.

    Article  PubMed  CAS  Google Scholar 

  • Hellberg P, Thomsen P, Janson PO, Brännström M. Leukocyte supplementation increases the luteinizing hormone-induced ovulation rate in the in vitro perfused rat ovary. Biol Reprod 1991b; 44: 791–797.

    Article  PubMed  CAS  Google Scholar 

  • Hirsch B, Leonhardt S, Jarry H, Reich R, Tsafriri A, Wuttke W. In vivo measurement of rat ovarian collagenases. Endocrinology 1993; 133: 2761–2765.

    Article  PubMed  CAS  Google Scholar 

  • Holmes PV, Janson PO, Sogn J, Källfelt B, LeMaire WJ, Ahrén K, Cajander S, Bjersing L. Effects of PGF2α and indomethacin on ovulation and steroid production in the isolated perfused rabbit ovary. Acta Endocr 1983; 104: 233–239.

    PubMed  CAS  Google Scholar 

  • Holmes PV, Sogn J, Schillinger E, Janson PO. Effects of high and low preovulatory concentrations of progesterone on ovulation from the isolated perfused rabbit ovary. J. Reprod Fert. 1985; 76: 393–399.

    Article  Google Scholar 

  • Hurwitz A, Ricciarelli E, Botero L, Katz E, McAllister JM, Garcia JE, Loukides J, Rohan RM, Adashi EY. The human intarovarian interleukin-1 (IL-1) system: Highly compartmentalized and hormonally-dependent regulation of the genes encoding IL-1 its receptor and its receptor antagonist. J Clin Invest 1991a; 129: 3427–3429.

    CAS  Google Scholar 

  • Hurwitz A, Ricciarelli E, Botero L, Rohan RM, Hernandez ER, Adashi EY. Endocrine-and autocrine-mediated regulation of rat ovarian (theca-interstitial) interleukin-1b gene expression: gonadotropin-dependent preovulatory acquisition. Endocrinology 1991b; 129: 3427–3429.

    Article  PubMed  CAS  Google Scholar 

  • Huslig RL, Malik A, Clark MR. Human chorionic gonadotropin stimulation of immunoreactive prostaglandin synthase in rat ovary. Mol Cell Endocrinol 1987; 50: 237–246.

    Article  PubMed  CAS  Google Scholar 

  • Ichikawa S, Morioka H, Oda M, Oda K, Murao S. Effects of various proteinase inhibitors on ovulation of explanted hamster ovaries. J Reprod Fertil 1983; 68 407–412.

    Article  PubMed  CAS  Google Scholar 

  • Itskovitz J, Sealey JE, Glorioso N, Rosenwaks Z. Plasma prorenin response to human chorionic gonadotropin in ovarian-hyperstimulated women: Correlation with the number of ovarian follicles and steroid hormone concentrations. Proc Natl Acad Sci.USA 1987; 84: 7285–7289.

    Article  PubMed  CAS  Google Scholar 

  • Janson PO. Effects of luteinizing hormone on blood in the follicular rabbit ovary as measured by radioactive microspheres. Acta Endocrinol 1975; 79: 122–123.

    PubMed  CAS  Google Scholar 

  • Janson PO, Amato F, Weiss T, Ralph M, Seamark RF. On the isolated perfused sheep ovary as a model for the study of ovarian function. Fertil Steril 1978; 30: 230–236.

    PubMed  CAS  Google Scholar 

  • Janson PO, LeMaire WJ, Källfelt B, Holmes PV, Cajander S, Bjersing L, Wiqvist N, Ahrén K. The study of ovulation in the isolated perfused rabbit ovary. I. Methodology and patterns of steroidogenesis. Biol Reprod 1982; 26: 456–465.

    CAS  Google Scholar 

  • Jia XC, Ny T, Hsueh AJW. Synergistic effect of glucocorticoids and androgens on the hormonal induction of tissue plasminogen activator activity and messenger ribonucleic acid levels in granulosa cells. Mol Cell Endocrinol 1990; 68: 143–151.

    Article  PubMed  CAS  Google Scholar 

  • Khan SA, Schmidt K, Hallin P, Pauli R, DeGeyter CH, Nieschlag E. Human testis cytosol and ovarian follicular fluid contain high amounts of interleukin-1-like factor(s). Mol Cell Endocrinol 1988; 58 221–230.

    Article  PubMed  CAS  Google Scholar 

  • Kikukawa Y, Ishikawa M, Sengoku K, Kasamo M, Shimizu T. The effect of platelet activating factor on ovulation. Prostaglandins 1991; 42: 95–104.

    PubMed  CAS  Google Scholar 

  • Killick S., Elstein M. Pharmacologic production of luteinized unruptured follicles by prostaglandin synthetase inhibitors. Fert Steril 1987; 47: 773–777.

    CAS  Google Scholar 

  • Knecht M. Plasminogen activator is associated with the extracellular matrix of ovarian granulosa cells. Mol Cell Endocr 1988; 56: 1–9.

    Article  CAS  Google Scholar 

  • Kokia E, Adashi EY. Potential role of cytokines in ovarian physiology: The case for interleukin-1. In: Adashi EY, Leung PCK, eds. The Ovary, Raven Press, New York, 1993; 383–394.

    Google Scholar 

  • Kokia E, Hurwitz A, Ben-Shlomo I, Adashi EY, Yanagishita M. Endocrinology 1993; 133: 2391–2394.

    Article  PubMed  CAS  Google Scholar 

  • Koos RD, Feiertag MA, Brodie AMH, LeMaire WJ. Inhibition of estrogen synthesis does not inhibit luteinizing hormone-induced ovulation. Am J Obstet Gynec 1984; 148 939–945.

    PubMed  CAS  Google Scholar 

  • Kuo TC, Endo K, Dharmarajan AM, Miyazaki T, Atlas SJ, Wallach EE. Direct effect of angiotensin II on in vitro perfused rabbit ovary. J Reprod Fert 1991; 92: 469–474.

    Article  CAS  Google Scholar 

  • Lambertsen C J, Greenbaum DF, Wright KH, Wallach EE. In vitro studies of ovulation in the perfused rabbit ovary. Fert Steril 1976; 27: 178–187.

    CAS  Google Scholar 

  • Lee W, Novy MJ. Effects of luteinizing hormone and indomethacin on blood flow and steroidogenesis in the rabbit ovary. Biol Reprod 1978; 18: 799–807.

    Article  PubMed  CAS  Google Scholar 

  • LeMaire WJ. Mechanism of mammalian ovulation. Steroids 1989; 54: 455–469.

    Article  PubMed  CAS  Google Scholar 

  • LeMaire WJ, Yang NST, Behrman HH, Marsh JM. Preovulatory changes in the concentration of prostaglandins in rabbit Graafian follicles. Prostaglandins 1973; 3: 367–376.

    PubMed  CAS  Google Scholar 

  • LeMaire WJ, Janson PO, Källfelt BJ, Holmes PV, Cajander S, Bjersing L, Ahrén K. The preovulatory decline in follicular estradiol is not required for ovulation in the rabbit. Acta endocr Cophenh 1982; 101: 452–457.

    CAS  Google Scholar 

  • LeMaire WJ, Curry TE, Morioka N, Brännstöm M, Clark MR, Woessner JF, Koos RD. Regulation of ovulatory processes. In: Stouffer RL, ed. The Primate Ovary, Plenum Publishing Corporation, New York, 1987; 91–111.

    Chapter  Google Scholar 

  • Li XM, Sagawa N, Ihara Y, Okagaki A, Hasegawa M, Inamori K, Itoh H, Mori T, Ban C. The involvement of platelet-activating factor in thrombocytopenia and follicular rupture during gonadotropin-induced superovulation in immature rats. Endocrinology 1991; 129, 3132–3138.

    Article  PubMed  CAS  Google Scholar 

  • Liedtke MP, Seifert B. Biosynthesis of prostaglandins in human ovarian tissues. Prostaglandins 1978; 16: 825–833.

    CAS  Google Scholar 

  • Lipner H. Mechanism of mammalian ovulation. In: Greep, R., ed. Handbook of Physiology, Endocrinology, II, part 1, American Physiological Society, Washington, DC, 1973; 409–437.

    Google Scholar 

  • Lipner H. Mechanism of mammalian ovulation. In: Knobil E, Neill J, eds. The Physiology of Reproduction, Raven Press Ltd, New York, 1988; 447–488.

    Google Scholar 

  • Lipner H, Greep RO. Inhibition of steroidogenesis at various sites in the biosynthetic pathway in relation to induced ovulation. Endocrinology 1971; 88: 602–607.

    Article  PubMed  CAS  Google Scholar 

  • Lipner H, Wendelken L. Inhibition of ovulation by inhibition of steroidogenesis in immature rats. Proc Soc exp Biol Med 1971; 136: 1141–1145.

    Article  PubMed  CAS  Google Scholar 

  • Liu Y-X, Peng X-R, Ny T. Tissue-specific and time-coordinated hormone regulation of plasminogen-activator-inhibitor type 1 and tissue-type plasminogen activator in the rat ovary during gonadotropin-induced ovulation. Eur J Biochem 1991; 195: 549–555.

    Article  PubMed  CAS  Google Scholar 

  • Löfman CO, Janson PO. Källfelt BJ, Ahrén K, LeMaire WJ. The study of ovulation in the isolated perfused rabbit ovary. II. Photographic and cinematographic observations. Biol Reprod 1982; 26: 467–473.

    Article  PubMed  Google Scholar 

  • Lumsden MA, Kelly RW, Templeton AA, van Look PFA, Swanston IA, Baird DT. Changes in the concentration of prostaglandins in preovulatory human follicles after administration of hCG. J Reprod Fert 1986; 77, 119–124.

    Article  CAS  Google Scholar 

  • Mann JS, Kindy MS, Edwards DR, Curry JTE. Hormonal regulation of matrix metalloproteinase inhibitors in rat granulosa cells and ovaries. Endocrinology 1991; 128: 1825–1832.

    Article  PubMed  CAS  Google Scholar 

  • Martin GG, Talbot P. The role of follicular smooth muscle cells in hamster ovulation. J Exp Zool 1981; 216: 469–482.

    Article  PubMed  CAS  Google Scholar 

  • Matrisian LM. Metalloproteinases and their inhibitors in matrix remodeling. TIG 1990; 6: 121–125.

    Article  PubMed  CAS  Google Scholar 

  • Miyazaki T, Sueoka K, Dharmarajan AM, Atlas SJ, Bulkley GB, Wallach EE. Effect of inhibition of oxygen free radical on ovulation and progesterone production by the in-vitro perfused rabbit ovary. J Reprod Fert. 1991; 91: 207–212.

    Article  CAS  Google Scholar 

  • Morales TI, Woessner JF, Howell DS, Marsh JM, LeMaire WJ. A microassay for lthe direct demonstration of collagenolytic activity in Graafian follicles of the rat. Biochim Biophys Acta 1978; 524: 428–434.

    Article  PubMed  CAS  Google Scholar 

  • Morales TI, Woessner JFJ, Marsh JM, LeMaire WJ. Collagen, collagenase and collagenolytic activity in rat Graafian follicles during follicular growth and ovulation. Biochim Biophys Acta 1983; 756: 119–122.

    Article  PubMed  CAS  Google Scholar 

  • Morioka N, Bränström M, Koos RD, LeMaire WJ. Ovulation in the perfused rat ovary in vitro: Further evidence that estrogen is not required. Steroids 1988; 51: 173–183.

    Article  PubMed  CAS  Google Scholar 

  • Murdoch WJ, McCormick RJ. Dose-dependent effects of indomethacin on ovulation in the sheep: relationship to follicular prostaglandin production, steroidogenesis, collagenolysis, and leukocyte chemotaxis. Biol Reprod 1991; 45: 907–911.

    Article  PubMed  CAS  Google Scholar 

  • Murdoch WJ, Steadman LE. Investigations concerning the relationship of ovarian eosinophilia to ovulation and luteal function in the sheep. Am J Reprod Immunol 1991; 25: 81–87.

    Article  PubMed  CAS  Google Scholar 

  • Murdoch WJ, Nix KJ, Dunn TG. Dynamics of ovarian blood supply to periovulatory follicles of the ewe. Biol Reprod 1983; 28: 1001–1006.

    Article  PubMed  CAS  Google Scholar 

  • Murdoch WJ, Peterson TA, Van Kirk EA, Vincent DL, Inskeep EK. Interactive roles of progesterone, prostaglandin, and collagenase in the ovulatory mechanism of the ewe. Biol Reprod 1986; 35: 1187–1194.

    Article  PubMed  CAS  Google Scholar 

  • Naftolin F, Andrade-Gordon P, Pellicer A, Palumbo A, Apa R, Zreik T, Yoon TK, DeCherney AH. (Response to) Angiotensin II: Does it have a direct obligate role in ovulation? Science 1989; 245: 870–871.

    Article  PubMed  CAS  Google Scholar 

  • Nakamura T, Takio K, Eto Y, Shibai H, Titani K, Sugino H. Activin-binding protein from rat ovary is follistatin. Science 1990; 247: 836–838.

    Article  PubMed  CAS  Google Scholar 

  • Ny T, Elgh F, Lund B. The structure of the human tissue type plasminogen activator gene. Correlation of intron and exon structures to functional and structural domains. Proc Natl Acad Sci USA 1984; 81: 5355–5359.

    Article  PubMed  CAS  Google Scholar 

  • Ny T, Bjersing L, Hsueh AJW, Loskutoff DJ. Cultured granulosa cells produce two plasminogen activators and an antiactivator, each regulated differently by gonadotropins. Endocrinology 1985; 116: 1666–1668.

    Article  PubMed  CAS  Google Scholar 

  • O’Shea JD. An ultrastructural study of smooth muslce-like cells in the theca externa of ovarian follicles in the rat. Anat Rec 1970; 167: 127–140.

    Article  PubMed  Google Scholar 

  • Okamura H, Virutamasen P, Wright KH, Wallach EE. Ovarian smooth muscle in the human being, rabbit, and cat. Am J Obstet Gynecol 1972; 112: 183–191.

    PubMed  CAS  Google Scholar 

  • Orczyk GP, Behrman HR. Ovulation blockade by aspirin or indomethacin: In vivo evidence for a role of prostaglandin in gonadotrophin secretion. Prostaglandins 1972; 1, 3–20.

    PubMed  CAS  Google Scholar 

  • Osvaldo-Decima L. Smooth muslce in the ovary of the rat and monkey. J Ultrastruct Res 1970; 29: 218–237.

    Article  Google Scholar 

  • Parr EL. Histological examination of the rat ovarian follicle wall prior to ovulation. Biol Reprod 1974; 11: 483–503.

    Article  PubMed  CAS  Google Scholar 

  • Parr EL. Rupture of ovarian follicles at ovulation. J Reprod Fertil (Suppl) 1975; 22: 1–22.

    Google Scholar 

  • Patwardhan VV, Lanthier A. Prostaglandins PGE and PGF in human ovarian follicles: Endogenous contents and in vitro formation by theca and granulosa cells. Acta Endocrinol 1981; 97: 543–550.

    PubMed  CAS  Google Scholar 

  • Pellicer A, Palumbo A, DeCherney AH, Naftolin F. Blockage of ovulation by an angiotensin antagonist. Science 1988; 240: 660–1661.

    Article  Google Scholar 

  • Peterson CM, Zhu C, Mukaida T, Butler TA., Woessner JF Jr, LeMaire WJ. The angiotensin II antagonist, saralasin, inhibits ovulation in the perfused rat ovary. Am J Obstet Gynecol 1993a; 168: 242–245.

    Article  PubMed  CAS  Google Scholar 

  • Peterson CM, Hales HA, Hatasaka HH, Mitchell MD, Rittenhouse L, Jones KP. Interleukin-1 modulatesprostaglandin production and the natural IL-1 receptor antagonist inhibits ovulation in the optimally stimulated rat ovarian perfusion model. Endocrinology 1993b; 133: 2301–2306.

    Article  PubMed  CAS  Google Scholar 

  • Plunkett ER, Moon YS, Zamecnik J, Armstrong DT. Preliminary evidence of a role for prostaglandin F in human follicular function. Am J Obstet Gynecol 1975; 123: 392–397.

    Google Scholar 

  • Politis I, Srikandakumar J, Turner JD, Tsang BK, Ainsworth L, Downey BR. Changes in and partial identification of the plasminogen activator and plasminogen activator inhibitor systems during ovarian follicular maturation in the pig. Biol Reprod 1990; 43: 636–642.

    Article  PubMed  CAS  Google Scholar 

  • Priddy AR, Killick SR, Elstein M, Morris J, Sullivan M, Patel L, Elder MG. Ovarian follicular fluid eicosanoid concentrations during the pre-ovulatory period in humans. Prostaglandins 1989; 38, 197–202.

    PubMed  CAS  Google Scholar 

  • Reich R, Kohen F, Naor Z, Tsafriri A. Possible involvement of lipoxygenase products of arachidonic acid pathway in ovulation. Prostaglandins 1983; 26: 1011–1019.

    PubMed  CAS  Google Scholar 

  • Reich R, Kohen F, Slager R, Tsafriri A. Ovarian lipoxygenase activity and its regulation by gonadotropin in the rat. Prostaglandins 1985a; 30: 581–590.

    PubMed  CAS  Google Scholar 

  • Reich R, Miskin R, Tsafriri A. Follicular plasminogen activator: Involvement in ovulation. Endocrinology 1985b; 116: 516–521.

    Article  PubMed  CAS  Google Scholar 

  • Reich R, Tsafriri A, Mechanic GL. The involvement of collagenolysis in ovulation in the rat. Endocrinology 1985c; 116: 521–527.

    Google Scholar 

  • Reich R, Miskin R, Tsafriri A. Intrafollicular distribution of plasminogen activators and their hormonal regulation in vitro. Endocrinology 1986; 119: 1588–1601.

    Article  PubMed  CAS  Google Scholar 

  • Reich R, Haberman S, Abisogun AO, Sofer Y, Grossman S, Adelmann-Grill BC, Tsafriri A. Follicular rupture at ovulation: Collagenase activity and metabolism of arachidonic acid. In: Naftolin F, deCherney A., eds. The Control of Follicle Development, Ovarian and Luteal Function: Lessons from in vitro Fertilization, Raven Press, 1987; 317-329.

    Google Scholar 

  • Reich R, Daphna-Iken D, Chun SY. Popliker M, Slager R, Adelmann-Grill BC, Tsafriri A. Preovulatory changes in ovarian expression of collagenases and tissue metalloproteinase inhibitor mRNA: Role of eicosanoids. Endocrinology 1991; 129: 1869–1875.

    Article  PubMed  CAS  Google Scholar 

  • Reinthaller A, Bieglmayer C, Kirchheimer JC, Christ G, Deutinger J, Binde BR. Plasminogen activators, plasminogen activator inhibitor, and fibronectin in human granulosa cells and follicular fluid related to oocyte maturation and intrafollicular gonadotropin levels. Fertil Steril 1990; 54: 1045–1051.

    PubMed  CAS  Google Scholar 

  • Riccio A, Grimaldi G, Verde P, Gebastio G, Boast S, Blasi F. The human urokinase plasminogen activator gene and its promotor. Nucleic Acid Res 1985; 13: 2759–2771.

    Article  PubMed  CAS  Google Scholar 

  • Rocerto T, Jacobowitz D, Wallach E. Observations of spontaneous contractions of the cat ovary in vitro. Endocrinology 1969; 84: 1336–1341.

    Article  Google Scholar 

  • Rondell P. Follicular pressure and distensibility. Am J Physiol 1964; 207: 590–594.

    PubMed  CAS  Google Scholar 

  • Rondell P. Biophysical aspects of ovulation. Biol Reprod Suppl 1970; 2: 64–89.

    Article  PubMed  CAS  Google Scholar 

  • Rondell P. Role of steroid synthesis in the process of ovulation. Biol Reprod 1974; 10: 199–215.

    Article  PubMed  CAS  Google Scholar 

  • Schochet SS. A suggestion as to the process of ovulation and ovarian cyst formation. Anat Rec 1916; 10: 447–457.

    Article  Google Scholar 

  • Sealey JE, Atlas SA, Glorioso N, Manapat, H, Laragh JH. Cyclical secretion of prorenin during the menstrual cycle: Synchronization with luteinizing hormone and progesterone. Proc Natl Acad Sci USA 1985; 82, 8705–8709.

    Article  PubMed  CAS  Google Scholar 

  • Sealey JE, Cholst I, Glorioso N, Torffa C, Weintraub ID, James, Larach JH. Sequential changes in plasma luteinizing hormone and plasma prorenin during the menstrual cycle. J Clin Endocrinol Metab 1987; 65, 1–5.

    Article  PubMed  CAS  Google Scholar 

  • Simon C, Frances A, Piquette GN, Polan ML. Immunohistochemical localization of the interleukin-1 system in the mouse ovary during follicular growth, ovulation and luteinization. Biol Reprod 1994a; 50,:449–457.

    Article  PubMed  CAS  Google Scholar 

  • Simon C, Tsafriri A, Chun S-Y, Piquette GN, Dang W, Polan ML. Interleukin-1 receptor antagonist suppresses hCG-induced ovulation in the rat. Biol Reprod 1994b; 51: 662–667.

    Article  PubMed  CAS  Google Scholar 

  • Sirois J, Richards J. Identification and characterization of a novel, distinct isoform of prostaglandin endoperoxide synthase. J Biol Chem 1991; 267: 6382–6388.

    Google Scholar 

  • Snyder BW, Beecham GD, Schane HP. Inhibition of ovulation in rats with epostane, an inhibitor of 3 β-hydroxysteroid dehydrogenase (41865). Proc Soc exp Biol Med 1984; 176: 238–242.

    Article  PubMed  CAS  Google Scholar 

  • Sogn JH, Curry TE, Brännström M, LeMaire WJ, Koose RD, Papkoff H, Janson PO. Inhibition of follicle-stimulating hormone induced ovulation by indomethacin in the perfused rat ovary. Biol Reprod 1987; 36: 536–542.

    Article  PubMed  CAS  Google Scholar 

  • Suenson E, Lötzen O, Thorsen S. Initial plasmin degradation of fibrin as the basis of a positive feed-back mechanism in fibrinolysis. Eur J Biochem 1984; 140: 513–522.

    Article  PubMed  CAS  Google Scholar 

  • Takehara Y, Dharmarajan AM, Kaufman G, Wallach EE. Effect of interleukin-1β on ovulation in the in vitro perfused rabbit ovary. Endocrinology 1994; 134: 1788–1793.

    Article  PubMed  CAS  Google Scholar 

  • Tanaka N, Espey L, Okamura H. Increase in ovarian 15-hydroxyeicosatetraenoic acid during ovulation in the gonadotropin-primed immature rat. Endocrinology 1989; 125: 1373–1377.

    Article  PubMed  CAS  Google Scholar 

  • Thibault C, Levasseur MC. Ovulation. Human Reprod 1988; 3: 513–523.

    CAS  Google Scholar 

  • Tonks NK, Diltz CD, Fischer EH. Characterization of the major protein-tyrosine-phosphatases of human placenta. J Biol Chem 1988; 263: 6731–6737.

    PubMed  CAS  Google Scholar 

  • Tsafriri A, Reich R. Plasminogen activators in the preovulatory follicle: Role in ovulation. In: Abbate R, Barni T, Tsafriri A, eds. Plasminogen Activators: From Cloning to Therapy, Raven Press, New York, 1991; 81–94.

    Google Scholar 

  • Tsafriri A, Lindner HR, Zor U, Lamprecht A. Physiological role of prostaglandins in the induction of ovulation. Prostaglandins 1972; 2: 1–10.

    PubMed  CAS  Google Scholar 

  • Tsafriri A, Abisogun AO, Reich R. Steroids and follicular rupture at ovulation. J steroid Biochem 1987; 27: 359–363.

    Article  PubMed  CAS  Google Scholar 

  • Tsafriri A, Bicsak TA. Cajander SB, Ny T, Hsueh AJW. Suppression of ovulation rate by antibodies to tissue type plasminogen activator and a2-antiplasmin. Endocrinology 1989; 124: 415–421.

    CAS  Google Scholar 

  • Tsafriri A, Daphna-Iken D, Abisogun AO, Reich R. Follicular rupture during ovulation: Activation of collagenolysis. In: Mashiach S, Ben-Rafael Z, Laufer N, Schenker J G, eds. Advances in Assisted Reproductive Technologies, Plenum Press, New York, 1991; 103–112.

    Google Scholar 

  • Tsafriri A, Chun SY, Reich R. Role of eicosanoids in the mediation of LH/hCG stimulation of ovarian collagenase and of ovulation The 8th International Conference on Prostaglandins and Related Compounds, Montreal, Canada, 1992; Abst. 510.

    Google Scholar 

  • Vassali JD, Sappino AP, Belin D. The plasminogen activator/plasmin system. J Clin Invest 1991; 88: 1067–1072.

    Article  Google Scholar 

  • Wallach EE, Bronson R, Hamada Y, Wright KH, Stevens VC. Effectiveness of prostaglandin F2a in restoration of HMG-HCG induced ovulation in indomethacin-treated rhesus monkeys. Prostaglandins 1975a; 10: 129–138.

    PubMed  CAS  Google Scholar 

  • Wallach EE, de la Cruz A, Hunt J, Wright KH, Stevens VC. The effect of indomethacin on HMG-HCG induced ovulation in the rhesus monkey. Prostaglandins 1975b; 9: 645–658.

    PubMed  CAS  Google Scholar 

  • Wallach EE, Wright KH, Hamada Y. Investigation of mammalian ovulation with an in vitro perfused rabbit ovary preparation. Am J Obstet Gynecol 1978; 132: 728–738.

    PubMed  CAS  Google Scholar 

  • Wang C, Leung A. Glucocorticoids stimulate plasminogen activator production by rat granulosa cells. Endocrinology 1989; 124: 1595–1601.

    Article  PubMed  CAS  Google Scholar 

  • Wang LJ, Norman RJ. Concentrations of immunoreactive interleukin-1 and interleukin-2 in human preovulatory follicular fluid. Hum Reprod 1992; 7: 147–150.

    PubMed  CAS  Google Scholar 

  • Werb Z. Proteinases and matrix degradation. In: Kelley WN, Harris Jr ED, Ruddy S, Sledge CB, eds. Textbook of Rheumatology, Chap. 18, W.B. Saunders, Philadelphia, 1989; 300–321.

    Google Scholar 

  • Woessner JJF, Butler WJ, LeMaire WJ, Morioka N, Mukaida T, Zhu C. The role of collagenase in ovulation in the rat. In: Tsafriri A, Dekel N, eds. Follicular Development and the Ovulatory Response, Ares-Serono Symposia, Rome, 1989; 23: 167–178.

    Google Scholar 

  • Wong WYL, Richards JS. Evidence for two antigenically distinct molecular weight variants of prostaglandin H synthase in the rat ovary. Mol Endocrinol 1991; 5: 1269–1279.

    Article  PubMed  CAS  Google Scholar 

  • Wurtman RJ An effect of luteinizing hormone on the fractional perfusion of the rat ovary. Endocrinology 1964; 75:927–933.

    Article  PubMed  CAS  Google Scholar 

  • Yoshimura Y, Wallach EE. Studies of the mechanism(s) of mammalian ovulation. Fertil Steril 1987; 47: 22–34.

    PubMed  CAS  Google Scholar 

  • Yoshimura Y, Hosoi Y, Atlas SJ, Bongiovanni AM, Santulli R. Wallach EE. The effect of ovarian steroidogenesis on ovulation and fertilizability in the in vitro perfused rabbit ovary. Biol Reprod 1986; 35: 943–948.

    Article  PubMed  CAS  Google Scholar 

  • Yoshimura Y, Espey L, Hosoi Y, Adashi T, Atlas SJ, Ghodgoaonkar RB, Dubin NH, Wallach E. The effects of bradykinin on ovulation and prostaglandin production by the perfused rabbit ovary. Endocrinology 1988; 122: 2540–2546.

    Article  PubMed  CAS  Google Scholar 

  • Yoshimura Y, Karube M, Koyama N, Shoikawa S, Nanno T, Nakamura Y Angiotensin II directly induces follicle rupture and oocyte maturation in the rabbit. FEBS Lett 1992a; 307:305–308.

    Article  PubMed  CAS  Google Scholar 

  • Zor U, Lamprecht SA. Mechanism of prostaglandin action in endocrine glands. In: Litwack G, ed. Biochemical Actions of Hormones, Academic Press, 1977; 4: 88–133.

    Google Scholar 

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  1. Department of Hormone Research, The Bernhard Zondek Hormone Research Laboratory, The Weizmann Institute of Science, Rehovot, 76100, Israel

    Alex Tsafriri

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  1. Institute for Hormone and Fertility Research, University of Hamburg, Hamburg, Germany

    Amal K. Mukhopadhyay Ph.D.

  2. University of Florida, Gainesville, Florida, USA

    Mohan K. Raizada Ph.D.

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Tsafriri, A. (1995). Ovulation as a Tissue Remodelling Process. In: Mukhopadhyay, A.K., Raizada, M.K. (eds) Tissue Renin-Angiotensin Systems. Advances in Experimental Medicine and Biology, vol 377. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0952-7_8

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