The Choriodecidual Renin Controversy Revisited

  • Myriam Hanssens
  • Lisbeth Vercruysse
  • Lieve Verbist
  • Robert Pijnenborg
  • Marc J. N. C. Keirse
  • F. André Van Assche
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 377)


Identification of the cell type that contains renin within the uteroplacental unit is important to further research in the physiological function of the renin-angiotensin system at this site. Using an anti-human renal renin monoclonal antibody F37.1A1/Sera-Lab, we found immunopositive staining in cells dispersed throughout the decidual layer of the fetal membranes (Hanssens et al 1994). A small number of immunopositive cells was seen in the chorion laeve while immunopositive cells were found only rarely in the chorionic and in the amnionic mesoderms. These cells have many characteristics of macrophages. They are small, variable in size and shape, and some are loaden with haemosiderin.


Double Staining Fetal Membrane Normal Human Serum Normal Mouse Serum Normal Full Term Pregnan 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Myriam Hanssens
    • 1
  • Lisbeth Vercruysse
    • 1
  • Lieve Verbist
    • 1
  • Robert Pijnenborg
    • 1
  • Marc J. N. C. Keirse
    • 2
  • F. André Van Assche
    • 1
  1. 1.The Department of Obstetrics and GynaecologyUniversity of LeuvenLeuvenBelgium
  2. 2.The Department of Obstetrics and GynaecologyLeiden UniversityLeidenThe Netherlands

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