The Ovarian Renin-Angiotensin System

A Paracrine-Intracrine Regulator of Ovarian Function
  • J. R. Pepperell
  • Y. Yamada
  • G. Nemeth
  • A. Palumbo
  • F. Naftolin
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 377)


We present a review that considers the regulation of ovarian function by the ovarian renin-angiotensin system. Evidence is presented that shows the ovarian renin-angiotensin system can regulate normal ovarian function by paracrine and intracrine mechanisms. In addition, the complexity that is inherent in the renin-angiotensin system conferred by multiple biological angiotensin peptides and multiple receptors is discussed. Evidence that a dysfunctional OVRAS induces ovarian pathology such as polycystic ovarian disease is also presented.


Angiotensin Converting Enzyme Granulosa Cell Follicular Fluid Oocyte Maturation Luteal Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • J. R. Pepperell
    • 1
  • Y. Yamada
    • 1
  • G. Nemeth
    • 1
  • A. Palumbo
    • 1
  • F. Naftolin
    • 1
  1. 1.Department of Obstetrics and Gynecology and Center for Research in Reproductive BiologyYale University, School of MedicineNew HavenUSA

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