Tissue Renin-Angiotensin Systems pp 15-32 | Cite as
Neuroendocrine Control of Reproduction
Abstract
The gametogenic and steroidogenic functions of the ovaries and the testes are controlled by numerous humoral, paracrine and neural signals. Of paramount importance are the pituitary gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) and, to a lesser extent, prolactin (Prl). The biosynthesis and release of these hormones are regulated by gonadal products and by a number of hypothalamic hormones or modulatory agents. This chapter will review some of the more important mechanisms controlling the release of these hypothalamic substances. Limitations of time and space prevent an exhaustive review of all hypothalamic factors that have been shown to influence LH, FSH and Prl release in view of the fact that the number of endogenous compounds reported to have these actions probably exceeds a 100. However, the number of substances that have proven or at least strongly suspected physiological effects is much smaller.
Keywords
Luteinizing Hormone Vasoactive Intestinal Peptide Prolactin Secretion Gamma Amino Butyric Acid Prolactin ReleasePreview
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References
- Abbud, R. and Smith, M.S. Differences in the LH and prolactin responses to multiple injections of kainate, as compared to N-methyl-D, L-aspartate in cycling rats. Endocrinology 129:3254–3258, 1991.PubMedCrossRefGoogle Scholar
- Adler, B.A. and Crowley, W.R. Evidence of gamma-aminobutyric acid modulationof ovarian hormonal effects on luteinizing hormone secretion and hypothalamic catecholamine activity in the female rat. Endocrinology 118:91–97, 1986.PubMedCrossRefGoogle Scholar
- Aguilera, G., Hyde, C. and Catt, K.J. Angiotensin II receptors and prolactin release in pituitary lactotrophs. Endocrinology 111:1045–1050, 1982.PubMedCrossRefGoogle Scholar
- Alexander, M.J., Clifton, D.K. and Steiner, R.A. Vasoactive intestinal polypeptide effects a central inhibition of pulsatile luteinizing hormone secretion in ovariectomized rats. Endocrinology 117:2134–2139, 1985.PubMedCrossRefGoogle Scholar
- Andersson, K., Siegel, R., Fuxe, K. and Eneroth, P. Intravenous injections of nicotine induce very rapid and discrete reductions of hypothalamic catecholamine levels associated with increases in ACTH, vaso-pressin and prolactin secretion. Acta Physiol. Scand. 118:35–40, 1983.PubMedCrossRefGoogle Scholar
- Anton-Tay, F., Anton, S.M. and Wurtman, R.J. Mechanism of changes in brain norepinephrine metabolism after ovariectomy. Neuroendocrinology 6:265–273, 1970.PubMedCrossRefGoogle Scholar
- Arbogast, L. A. and Ben-Jonathan, N. The preovulatory prolactin surge is prolonged by a progesterone-dependent dopaminergic mechanism. Endocrinology 126:246–252, 1990.PubMedCrossRefGoogle Scholar
- Arey, B.J. and Freeman, M.E. Oxytocin, vasoactive-intestinal peptide, and serotonin regulate the mating-in-duced surges of prolactin secretion in the rat. Endocrinology 126:279–284, 1990.PubMedCrossRefGoogle Scholar
- Arey, B.J. and Freeman, M.E. Activity of oxytocinergic neurons in the paraventricular nucleus mirrors the periodicity of the endogenous stimulatory rhythm regulating prolactin secretion. Endocrinology 130:126–132, 1992.PubMedCrossRefGoogle Scholar
- Babu, G.N. and Vijayan, E. Hypothalamic tyrosine hydroxylase activity and plasma gonadotropin and prolactin levels in ovariectomized steroid treated rats. Brain Res Bull 12:555–558, 1984.PubMedCrossRefGoogle Scholar
- Bapna, J., Neff, N.H. and Costa, E. A methof for studying norepinephrine and serotonin metabolism in small regions of the brain: Effect of ovariectomy on amine metabolism on anterior and posterior hypothalamus. Endocrinology 89:1345–1349, 1971.PubMedCrossRefGoogle Scholar
- Barraclough, C. and Wise, P. The role of catecholamines in the regulation of pituitary LH and FSH secretion. Endocrin. Rev. 3:91–119, 1982.CrossRefGoogle Scholar
- Bauer-Dantoin, A.C., Urban, J.H. and Levine, J.E. Neuropeptide Y gene expression in the arcuate nucleus is increased during preovulatory luteinizing hormone surges. Endocrinology 131:2953–2958, 1992.PubMedCrossRefGoogle Scholar
- Becú-Villalobos, D., Lacau-Mengido, I.M., Thyssen, S.M., Diaz-Torga, G.S. and Libertun, C. Effects of LHRH and ANG II on prolactin Stimulation are mediated by hypophysial AT1 receptor subtype. Am J. Physiol. Endocrinol. Metab. 266:E274–E278, 1994.Google Scholar
- Ben-Jonathan, N., Arbogast, L.A. and Hyde, J.F. Neuroendrocrine regulation of prolactin release. Prog. Neurobiol. 33:399–447, 1989.PubMedCrossRefGoogle Scholar
- Ben-Jonathan, N. and Liu, J.-W. Pituitary lactotrophs: Endocrine, paracrine, juxtacrine, and autocrine interactions. Trends Endocrinol. Metab. 3: 254–258, 1992.PubMedCrossRefGoogle Scholar
- Besecke, L.M. and Levine, J.E. Acute increases in responsiveness of luteinizing hormone (LH)-releasing hormone nerve terminals to neuropeptide-Y stimulation before the preovulatory LH surge. Endocrinology 135: 63–66, 1994.PubMedCrossRefGoogle Scholar
- Bjoro, T., Sand, O., Ostberg, B.C., et al. The mechanisms by which vasoactive intestinal peptide (VIP) and thyrotropin releasing hormone (TRH) stimulate prolactin release from pituitary cells. Biosci. Rep. 10: 189–200, 1990.PubMedCrossRefGoogle Scholar
- Blake, C.A. and Sawyer, C.H. Nicotine blocks the suckling induced rise in circulating prolactin in lactating rats. Science 177: 619–621, 1972.PubMedCrossRefGoogle Scholar
- Bonavera, J.J., Sahu, A., Kalra, P.S. and Kalra, S.P. Evidence that nitric oxide may mediate the ovarian steroid-induced luteinizing hormone surge: Involvement of excitatory amino acids. Endocrinology 133: 2481–2487, 1993.PubMedCrossRefGoogle Scholar
- Bourguignon, J.P., Gerard, A. and Franchimont, P. Direct activation of gonadotropin-releasing hormone secretion through different receptors to neuroexcitatory amino acids. Neuroendocrinology 49: 402–408, 1989.PubMedCrossRefGoogle Scholar
- Bradshaw, W.G., Irskine, M.S. and Baum, M.J. Dissociation of the effects of gonadal steroids on brain serotonin metabolism and sexual behavior in the male rat. Neuroendocrinology 34: 38–45, 1982.PubMedCrossRefGoogle Scholar
- Brann, D.W. and Mahesh, V.B. Endogenous excitatory amino acid regulation of the progesterone-induced LH and FSH surge in estrogen-primed ovariectomized rats. Neuroendocrinology 53: 107–110, 1991.PubMedCrossRefGoogle Scholar
- Brann, D.W. and Mahesh, V.B. Excitatory amino acids: function and significance in reproduction and neuroendocrine regulation. Front Neuroendocrinol 15: 1–49, 1994.CrossRefGoogle Scholar
- Brann, D.W., Rao, I.M. and Mahesh, V.B. Antagonism of estrogen-induced prolactin release by progesterone. Biol Reprod 39: 1067–1073, 1988.PubMedCrossRefGoogle Scholar
- Bruni, J.F., Van Vugt, D., Marshall, S. and Meites, J. Effects of naloxone, morphine and methionine enkephalin on serum prolactin, luteinizing hormone, follicle-stimulating hormone, thyroid stimulating hormone and growth hormone. Life Sci 21: 461–466, 1977.PubMedCrossRefGoogle Scholar
- Burris, T.P., Stringer, L.C. and Freeman, M.E. Pharmacologic evidence that a D2 receptor subtype mediates dopaminergic stimulation of prolactin secretion from the anterior pituitary gland. Neuroendocrinology 54: 175–183, 1991.PubMedCrossRefGoogle Scholar
- Chen, M.F., Hawkins, R. and Printz, M.P. Evidence for a functional independent brain-angiotensin system: correlation between regional distribution of brain AII receptors, brain angiotensinogen and drinking during the estrous cycle of the rat. In: The Renin-Angiotensin System in the Brain, edited by Ganten, D., Printz, M., Phillips, M.I. and Scholkens, B.A. New York: Raven Press, 1982, p. 157–168.CrossRefGoogle Scholar
- Chihara, K., Arimura, A. and Schally, A.V. Immunoreactive somatostatin in rat hypophysial portal blood: effects of anesthetics. Endocrinology 104: 1434–1441, 1979.PubMedCrossRefGoogle Scholar
- Cho, B.N., Suh, Y.H., Yoon, YD., Lee, C.C. and Kim, K. Progesterone inhibits the estrogen-induced prolactin gene expression in the rat pituitary. Mol. Cell. Endocrinol. 93: 47–52, 1993.PubMedCrossRefGoogle Scholar
- Crowley, W.R. and Kalra, S.P. Neuropeptide Y stimulates the release of luteinizing hormone releasing hormone from medial basal hypothalamus in vitro: modulation by ovarian hormones. Neuroendocrinology 46: 97–103, 1987.PubMedCrossRefGoogle Scholar
- Crowley, W.R., O’Donohue, T.L. and Jacobowitz, D.M. Changes in catecholamine content in discrete brain nuclei during the estrous cycle of the rat. Brain Res 147: 315–326, 1978.PubMedCrossRefGoogle Scholar
- Crowley, W.R., Shah, G.V., Carroll, B.L., Kennedy, D., Dockter, M.E. and Kalra, S.P. Neuropeptide-Y enhances luteinizing hormone (LH)-releasing hormone-induced LH release and elevations in cytosolic Ca2+ in rat anterior pituitary cells: evidence for involvement of extracellular Ca2+ influx through voltage-sensitive channels. Endocrinology 127: 1487–1494, 1990.PubMedCrossRefGoogle Scholar
- Crowley, W.R., Tessel, R.E., O’Donohue, T.L., Adler, B.A. and Kalra, S.P. Effects of ovarian hormones on the concentration of immunoreactive neuropeptide Y in discrete brain regions of the female rat: correlation with serum LH and median eminence LHRH. Endocrinology 117: 1151–1155, 1985.PubMedCrossRefGoogle Scholar
- Dannies, P.S. Control of prolactin production by estrogen. In: Biochemical Action of Hormones. Vol 12, edited by Litwack, G. New York: Academic Press, 1985, p. 289–307.CrossRefGoogle Scholar
- De Greef, W.J., Klootwijk, W., Karels, B. and Visser, T.J. Levels of dopamine and thyrotropin-stimulating hormone in hypophysial stalk blood during an oestrogen-stimulated surge of prolactin in the ovariectomized rat. Journal of Endocrinology 105: 107–112, 1985.PubMedCrossRefGoogle Scholar
- DePaolo, L.V., Bicsak, T.A., Erickson, G.F., Shimasaki, S. and Ling, N. Minireview: Follistatin and activin: apotential intrinsic regulatory system within diverse tissues. Proc. Soc. Exp. Biol. Med. 198: 500–512, 1991.CrossRefGoogle Scholar
- De Castro-e-Silva, E.J. and Antunes-Rodrigues, J. Central adrenoreceptors and basla prolactin release in the rat. Horm Metab Res 21: 179–181, 1989.PubMedCrossRefGoogle Scholar
- Demling, J., Fuchs, E., Baumert, M. and Wuttke, W. Preoptic catecholamine, GABA and glutamate release in ovariectomized and ovariectomized estrogen-primed rats utilizing a push-pull cannula technique. Neuroendocrinology 41: 212–218, 1985.PubMedCrossRefGoogle Scholar
- Denef, C., Baes, M. and Schramme, C. Paracrine interactions in the anterior pituitary: Role in the regulation of prolactin and growth hormone secretion. In: Frontiers in Neuroendocrinology. Vol 9, edited by Ganong, W.F. and Martini, L. New York: Raven Press, 1986, p. 115–148.Google Scholar
- Denef, C., Manet, D. and Dewals, R. Dopaminergic stimulation of prolactin release. Nature 285: 243–246, 1980.PubMedCrossRefGoogle Scholar
- Drouva, S.V., Rerat, E., Bihoreau, C, et al. Dihydropyridine-sensitive calcium channel activity related to prolactin, growth hormone, and luteinizing hormone release from anterior pituitary cells in culture: interactions with somatostatin, dopamine and estrogens. Endocrinology 123: 2762–2773, 1988.PubMedCrossRefGoogle Scholar
- Dunn, J.D., Johnson, D.C., Castro, A.J. and Swenson, R. Twenty-four hour pattern of prolactin levels in female rats subjected to transection of the mesencephalic raphe or ablation of the suprachiasmatic nuclei. Neuroendocrinology 31: 85–91, 1980.PubMedCrossRefGoogle Scholar
- Elde, R. and Hökfelt, T. Distribution of hypothalamic hormones and other peptides in the brain. In: Frontiers in Neuroendocrinology, Vol. 5, edited by Ganong, W.F. and Martini, L. New York: Raven Press, 1978, p. 1–33).Google Scholar
- Ellerkmann, E., Nagy, G.M. and Frawley, L.S. Rapid augmentation of prolactin cell number and secretory capacity by an estrogen-induced factor released from the neurointermediate lobe. Endocrinology 129: 838–842, 1991.PubMedCrossRefGoogle Scholar
- Ellis, G.B. and Desjardins, C. Male rats secrete LH and testosterone episodically. Endocrinology 110: 1618–1627, 1982.PubMedCrossRefGoogle Scholar
- Ferraro, J.S. and Steger, R.W. Diurnal variations in brain serotonin are driven by the photic cycle and are not circadian in nature. Brain Res 512: 121–124, 1990.PubMedCrossRefGoogle Scholar
- Fischette, C.T., Bigon, A. and McEwen, B.S. Sex differences in serotonin 1 binding in rat brain. Science 222: 333–335, 1983.PubMedCrossRefGoogle Scholar
- Franci, C.R., Anselmo-Franci, J.A. and McCann, S.M. Opposite effects of central immunoneutralization of angiotensin II or atrial natriuretic peptide on luteinizing hormone release in ovariectomized rats. Neuroendocrinology 51: 683–687, 1990.PubMedCrossRefGoogle Scholar
- Fuxe, K. and Hökfelt, T. Central monaminergic systems and hypothalamus function. In: The Hypothalamus, edited by Martini, L., Motta, M. and Fraschini, F. New York: Academic Press, 1970, p. 123–138).Google Scholar
- Gallo, R.V. Neuroendocrine regulation of pulsatile LH release in the rat. Neuroendocrinology 30: 122–131, 1980.PubMedCrossRefGoogle Scholar
- Ganten, D., Fuxe, K., Phillips, M.I., Mann, J.F.E. and Ganten, U. The brain isorenin-angiotensin system: Biochemistry, localization, and possible role in drinking and blood presseure regulation. In: Frontiers in Neuroendocrinology, Vol 5, edited by Ganong, W.F. and Martini, L. New York: Raven Press, 1978, p. 61–99).Google Scholar
- Grandison, L. Effects of cholinergic agonists and antagonists on anterior pituitary hormone secretion. In: Handbook of Pharmacologic Methodologies for the Study of the Neuroendocrine System, edited by Steger, R.W. and Johns, A. Boca Raton: CRC Press, 1985, p. 155–172).Google Scholar
- Grandison, L. and Guidotti, A. Regulation of prolactin release by endogenous opiates. Nature 270: 357–359, 1977.PubMedCrossRefGoogle Scholar
- Grattan, D.R. and Selmanoff, M. Regional variation in gamma-aminobutyric acid turnover: Effect of castration on gamma-aminobutyric acid turnover in microdissected brain regions of the male rat. J Neurochem. 60: 2254–2264, 1993.PubMedCrossRefGoogle Scholar
- Gudelsky, G.A. Tuberoinfundibular dopamine neurons and the regulation of prolactin secretion. Psychoneuroendocrinology 6: 3–16, 1981.PubMedCrossRefGoogle Scholar
- Hales, T.G., Sanderson, M.J. and Charles, A.C. GABA has excitatory actions on GnRH-secreting immortalized hypothalamic (GT1-7) neurons. Neuroendocrinology 59: 297–308, 1994.PubMedCrossRefGoogle Scholar
- Haläsz, B. Neuroendocrinology in 1992. Neuroendocrinology 57: 1196–1207, 1993.PubMedCrossRefGoogle Scholar
- Hartman, R.D., He, J.R. and Barraclough, C.A. Gama-amino-butyric acid-A and-B receptor anatagonists increase luteinizing hormone-releasing hormone neuronal responsiveness to intracerrebroventricular norepinephrine in ovariectomized estrogen-treated rats. Endocrinology 127: 1336–1345, 1990.PubMedCrossRefGoogle Scholar
- Haug, E. Progesterone suppression of estrogen-stimulated prolactin secretion and estrogen receptor levels in the rat pituitary. Endocrinology 104:429, 1979.PubMedCrossRefGoogle Scholar
- Horvath, T.L., Naftolin, F. and Leranth, C. b-Endorphin innervation of dopamine neurons in the rat hypothalamus: A light and electron microscopic double immunostaining study. Endocrinology 131: 1547–1555, 1992.PubMedCrossRefGoogle Scholar
- Horvath, T.L., Naftolin, F. and Leranth, C. Luteinizing hormone-releasing hormone and gamma-aminobutyric acid neurons in the medial preoptic area are synaptic targets of dopamine axons originating in anterior peri ventricular areas. J. Neuroendocrinol 5: 71–79, 1993.PubMedCrossRefGoogle Scholar
- Hulihan-Giblin, B.A., Lumpkin, M.D. and Kellar, K.J. Acute Effects of Nicotine on Prolactin Release in the Rat: Agonist and Antagonist effects of a Single Injection of Nicotine. J. PHARMACOLOGY and EXPERIMENTAL THERAPEUTICS 252: 15–19, 1990.Google Scholar
- Inenaga, K. and Mason, W.T. Gamma-aminobutyric acid modulates chloride channel activity in cultured primary bovine lactotrophs. Neuroscience 23: 649–660, 1987.PubMedCrossRefGoogle Scholar
- Jimenez, A. and Walker, R.F. The serotonergic system. In: Handbook of Pharmacologic Methodologies for the Study of the Neuroendocrine System, edited by Steger, R.W. and Johns, A. Boca Raton: CRC Press, 1985, p. 109–154).Google Scholar
- Johnston, C.A. and Negro-Vilar, A. Maturation of the prolactin and proopiomelanocortin-derived peptide responses to ether stress and morphine: neurochemical analysis. Endocrinology 118: 797–804, 1986.PubMedCrossRefGoogle Scholar
- Johnston, C.A., Tesone, M. and Negro-Vilar, A. Cellular mechanisms of acute estrogen negative feedback on LH secretion: norepinephrine, dopamine and 5-hydroxytryptamine metabolism in discrete brain regions. Brain Res Bull 13: 363–369, 1984.PubMedCrossRefGoogle Scholar
- Jorgensen, H., Knigge, U. and Warberg, J. Involvement of 5-HT1, 5-HT2, and 5-HT3 receptors in the mediation of the prolactin response to serotonin and 5-hydroxytryptophan. Neuroendocrinology 55: 336–343, 1992.PubMedCrossRefGoogle Scholar
- Kalra, S.P. Neural circuitry involved in the control of LHRH secretion: A mpdel for preovulatory LH release. In: Frontiers in Neuroendocrinology. Vol 9, edited by Ganong, W.F. and Martini, L. New York: Raven Press, 1986, p. 31–75).Google Scholar
- Kalra, S.P. and McCann, S.M. Effects of drugs modifying catecholamine synthesis on plasma LH and ovulation in the rat. Neuroendocrinology 15: 79–91, 1974.PubMedCrossRefGoogle Scholar
- Kapoor, R., Chapman, I.M. and Willoughby, J.O. a2 and b adrenoceptors in the mediobasal hypothalamus and a2 adrenoceptors in the preoptic-anterior hypothalamus stimulate prolactin secretion in the conscious male rat. J. Neuroendocrinol. 5: 189–193, 1993.PubMedCrossRefGoogle Scholar
- Kapoor, R. and Willoughby, J.O. Activation of opioid receptors in the mediobasal hypothalamus stimulates prolactin secretion in the conscious rat. J. Neuroendocrinol. 2: 347–350, 1990.PubMedCrossRefGoogle Scholar
- Kaufman, S. The dipsogenic activity of prolactin in male and female rats. J Physiol (Lond.) 310: 435–444, 1981.Google Scholar
- Kimura, F., Mitsugi, N., Arita, J., Akema, T. and Yoshida, K. Effects of preoptic injections of gastrin, cholecystokinin, secretin, vasoactive intestinal peptide, and PHI on the secretion of luteinizing hormone and prolactin in ovariectomized oestrogen-primed rats. Brain Res 410: 315–322, 1987.PubMedCrossRefGoogle Scholar
- King, T.S., Steger, R.W. and Morgan, W.W. Effect of hypophysectomy and subsequent prolactin administration on hypothalamic 5-hydroxytryptamine synthesis in ovariectomized rats. Endocrinology 116: 485–491, 1985.PubMedCrossRefGoogle Scholar
- King, T.S., Steger, R.W. and Morgan, W.W. Effect of ovarian steroids to stimulate region-specific hypothalamic 5-hydroxytryptamine synthesis in ovariectomized rats. Neuroendocrinology 42: 344–350, 1986.PubMedCrossRefGoogle Scholar
- Kiss, J. and Halasz, B. Synaptic connections between serotonergic axon terminals and tyrosine hydroxylase-immunoreactive neurons in the arcuate nucleus of the rat hypothalamus. A combination of electron microscopic autoradiography and immunocytochemistry. Brain Res 364: 284–294, 1986.PubMedCrossRefGoogle Scholar
- Koshiyama, H., Kato, Y, Ishikawa, Y, Murakami, Y, Inoue, T. and Imura, H. Stimulation of prolactin Secretion by L-3,4-Dihydroxyphenyl-serine (L-DOPS) Via Central Norepinephrine in the Rat. Life Sci 41:938–988, 19CrossRefGoogle Scholar
- Kuan, S.I., Login, I.S., Judd, A.M. and MacLeod, R.M. A comparison of the concentration-dependent actions of thyrotropin-releasing hormone, angiotensin II, bradykinin, and Lys-bradykinin on cytosolic free calcium dynamics in rat anterior pituitary cells: Selective effects of dopamine. Endocrinology 127: 1841–1848, 1990.PubMedCrossRefGoogle Scholar
- Kubota, T. and Aso, T. Role of angiotensin on paracrine prolactin release in the pituitary gland and its possible effects on ovarian function. Horm. Res. 35 Suppl. 1:13–20, 1991.PubMedCrossRefGoogle Scholar
- Lamberts, R., Vijayan, E., Graf, M., Mansky, T. and Wuttke, W. Involvement of preoptic-anterior hypothalamic GABA neurons in the regulation of pituitary LH and prolactin release. Exp Brain Res 52: 256–362, 1983.CrossRefGoogle Scholar
- Lamberts, S.W.J. and MacLeod, R.M. Regulation of prolactin secretion at the level of the lactotroph. Physiol. Rev. 70: 279–318, 1990.PubMedGoogle Scholar
- Leadem, CA., Crowley, W.R., Simpkins, J.W. and Kalra, S.P. Effects of naloxone on catecholamine and LHRH release from the perifused hypothalamus of the steroid-primed rat. Neuroendocrinology 40: 497–500, 1985.PubMedCrossRefGoogle Scholar
- Levine, J.E. and Duffy, M.T. Simultaneous measurement of luteinizing hormone (LH)-releasing hormone, LH and follicle stimulating hormone in intact and short-term castrated rats. Endocrinology 112: 2211–2221, 1988.CrossRefGoogle Scholar
- Locatelli, V., Cocchi, D., Frigerio, C, et al. Dual gamma-aminobutyric acid control of prolactin secretion in the rat. Endocrinology 105: 778–785, 1979.PubMedCrossRefGoogle Scholar
- Loose, M.D., Ronnekleiv, O. and Kelly, M.J. Neurons in the rat arcuate nucleus are hyperpolarized by GABA-B and u-opioid receptor agonists: evidence for convergence at a ligand-gated potassium conductance. Neuroendocrinology 54: 537–544, 1991.PubMedCrossRefGoogle Scholar
- Lopez, F.J. and Negro-Vilar, A. Galanin stimulates luteinizing hormone-releasing hormone secretion from arcuate nucleus-median eminence fragments in vitro: Involvement of an a-adrenergic mechanism. Endocrinology 127: 2431–2436, 1990.PubMedCrossRefGoogle Scholar
- Lumpkin, M.D., Samson, W.K. and McCann, S.M. Hypothalamic and pituitary sites of action of oxytocin to alter prolactin secretion in the rat. Endocrinology 112: 1711–1717, 1983.PubMedCrossRefGoogle Scholar
- Mahesh, V.B., Murphy, L.L. and O’Conner, J.L. Selective modulation of FSH and LH secretion by steroids. In: Regulation of Ovarian and Testicular Function, edited by Mahesh, V.B., Dhindsa, D.S., Anderson, E. and Kalra, S.P. New York: Plenum Publ Corp, 1987, p. 131–152).CrossRefGoogle Scholar
- Marks, D.L., Lent, K.L., Rossmanith, W.G., Clifton, D.K. and Steiner, R.A. Activation-dependent regulation of galanin gene expression in gonadotropin-releasing hormone neurons in the female rat. Endocrinology 134: 1991–1998, 1994.PubMedCrossRefGoogle Scholar
- Masotto, C, Wisniewski, G. and Negro-Vilar, A. Different gamma-aminobutyric acid receptor subtypes are involved in the regulation of opiate dependent and independent luteinizing hormonreleasing hormone secretion. Endocrinology 125: 548–553, 1989.PubMedCrossRefGoogle Scholar
- Matsushita, N., Kato, Y., Shimatsu, A., Katakami, H., Yanaihara, N. and Imura, H. Effects of VIP, TRH, GABA and dopamine on prolactin release from superfused rat anterior pituitary cells. Life Sci 32: 1263–1269, 1983.PubMedCrossRefGoogle Scholar
- McCann, S.M., Mizunuma, H., Samson, W.K. and Lumpkin, M.D. Differential hypothalamic control of FSH secretion: A review. Psychoneuroendocrinology 8:299, 1983.PubMedCrossRefGoogle Scholar
- Merchenthaler, I., Lopez, F.J. and Negro-Vilar, A. Colocalization of galanin and Luteinizing hormone-releasing hormone in a subset of hypothalamic neurons: anatomical and functional correlates. Proc. Natl. Acad. Sci. U.S.A. 87: 6326–6330, 1990.PubMedCrossRefGoogle Scholar
- Mistry, A. and Voogt, J.L. Role of serotonin in nocturnal and diurnal surges of prolactin in the pregnant rat. Endocrinology 125: 2875–2880, 1989.PubMedCrossRefGoogle Scholar
- Mogg, R.J. and Samson, W.K. Interactions of dopaminergic and peptidergic factors in the control of prolactin release. Endocrinology 126: 728–735, 1990.PubMedCrossRefGoogle Scholar
- Moguilevsky, J.A., Justo, G., Justo, S., Szwarcfarb, B., Carbone, S. and Scacchi, P. Modulatory effect of testosterone on the serotoninergic control of prolactin secretion in prepubertal rats. Neuroendocrinology 51: 197–201, 1990.PubMedCrossRefGoogle Scholar
- Moore, K.E. and Demarest, K.T. Tuberoinfundibular and tuberohypophyseal dopaminergic neurons. Front Neuroendocrinol 7:161–189, 1982.Google Scholar
- Moretto, M., López, F.J. and Negro-Vilar, A. Nitric oxide regulates luteinizing hormone-releasing hormone secretion. Endocrinology 133: 2399–2402, 1993.PubMedCrossRefGoogle Scholar
- Muckerjee, A., Kulkarni, P., McCann, S.M. and Negro-Vilar, A. Evidence for the presence and characterization of angiotensin II receptors in rat anterior pituitary membranes. Endocrinology 110:665, 1982.CrossRefGoogle Scholar
- Murai, I. and Ben-Jonathan, N. Posterior pituitary lobectomy abolishes the suckling-induced rise in prolactin: Evidence for a prolactin releasing factor in posterior pituitary. Endocrinology 121: 205–211, 1987.PubMedCrossRefGoogle Scholar
- Myers, L.S. and Steele, M.K. The brain renin-angiotensin system and prolactin secretion in the male rat. Endocrinology 129: 1744–1748, 1991.PubMedCrossRefGoogle Scholar
- Nagy, G., Mulchahey, J.J. and Neill, J.D. Autocrine control of prolactin secretion by vasoactive intestinal peptide. Endocrinology 122: 364–366, 1988.PubMedCrossRefGoogle Scholar
- Navarra, P., Eechaute, W., Preziosi, P. and Lacroix, E. a2-Adrenoceptor-mediated inhibition of prolactin release in suckling-or fenfluramine-induced hyperprolactinemia. Horm. Metab. Res. 23: 213–217, 1991.PubMedCrossRefGoogle Scholar
- Ojeda, S.R., Dissen, G.A. and Junier, M.P. Neurotrophic factors and female sexual development. Front. Neuroendocrinol. 13: 120–162, 1992.PubMedGoogle Scholar
- Ondo, J.G., Wheeler, D.D. and Dom, R.M. Hypothalamic site of action for N-methyl-D-aspartate (NMDA) on LH secretion. Life Sci 43: 2283–2286, 1988.PubMedCrossRefGoogle Scholar
- Parker, S.L. and Crowley, W.R. Stimulation of oxytocin releases in the lactating rat by central excitatory amino acid mechanisms: Evidence for specific involvement of R, S,-alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid-sensitive glutamate receptors. Endocrinology 133: 2847–2854, 1993.PubMedCrossRefGoogle Scholar
- Parker, S.L., Kalra, S.P. and Crowley, W.R. Neuropeptide Y modulates the binding of a gonadotropin-releasing hormone (GnRH) analog to anterior pituitary GnRH receptor sites. Endocrinology 128: 2309–2316, 1991.PubMedCrossRefGoogle Scholar
- Pasqualini, C, Bojda, F. and Kerdelhue, B. Direct effect of estradiol on the number of dopamine receptors in the anterior pituitary of ovariectomized rats. Endocrinology 119: 2484–2489, 1986.PubMedCrossRefGoogle Scholar
- Pawlikowski, M., Kunert-Radek, J., Stepien, H. and Radek, A. Effects of angiotensin II on proliferation of estrogen-induced rat pituitary tumor and human prolactinoma cells in vitro. Neuroendocrinol. Lett. 16: 103–109, 1994.Google Scholar
- Phillips, M.I., Wang, H., Kimura, B., Rejtman, M., Koduri, P. and Kalra, S.P. Dynamic changes in hypothalamic angiotensin II levels and release in association with progesterone-induced luteinizing hormone surge. Endocrinology 132: 1637–1642, 1993.PubMedCrossRefGoogle Scholar
- Pilotte, N.S. and Porter, J.C. Dopamine in hypophysial portal plasma and prolactin in systemic plasma of rats treated with 5-hydroxytryptamine. Endocrinology 108: 2137–2141, 1981.PubMedCrossRefGoogle Scholar
- Ping, L., Mahesh, V.B., Wiedmeier, V.T. and Brann, D.W. Release of glutamate and aspartate from the preoptic area during the progesterone-induced LH surge: In vivo microdialysis studies. Neuroendocrinology 59: 318–324, 1994.PubMedCrossRefGoogle Scholar
- Rettori, V, Kamat, A. and McCann, S.M. Nitric oxide mediates the stimulation of luteinizing-hormone releasing hormone release induced by glutamic acid in vitro. Brain Res. Bull. 33: 501–503, 1994.PubMedCrossRefGoogle Scholar
- Sahu, A., Crowley, W.R. and Kalra, S.P. Hypothalamic neuropeptide-Y gene expression increases before the onset of the ovarian steroid-induced luteinizing hormone surge. Endocrinology 134: 1018–1022, 1994.PubMedCrossRefGoogle Scholar
- Savoy-Moore, R.T. and Schwartz, N.B. Differential control of LH and FSH secretion. In: International Review of Physiology. Vol 22, edited by Greep, R.O. Baltimore: Yniversity Park Press, 1980, p. 203–248).Google Scholar
- Sawyer, C.H. Some recent developments in brain-pituitary-ovarian physiology. Neuroendocrinology 17: 97–124, 1975.PubMedCrossRefGoogle Scholar
- Sheward, W.J., Fraser, H.M. and Fink, G. Effect of immunoneutralization of thyrotropin-releasing hormone on the release of thyrotropin and prolactin during suckling or in response to electrical stimulation of the hypothalamus in the anesthetized rat. Journal of Endocrinology 106: 113–119, 1985.PubMedCrossRefGoogle Scholar
- Simpkins, J. W., Huang, H.H., Advis, J.P. and Meites, J. Changes in hypothalamic NE and DA turnover resulting from steroid-induced LH and prolactin surges in ovariectomized rats. Biol Reprod 20: 625–632, 1979.PubMedCrossRefGoogle Scholar
- Simpkins, J.W. and Kalra, S.P. Blockage of progesterone-induced increase in hypothalamic LHRH and serum gonadotropins by intrahypothalamic implantation of 6-hydroxydopamine. Brain Res 170: 475–484, 1979.PubMedCrossRefGoogle Scholar
- Sortino, M.A., Aleppo, G., Scapagnini, U. and Canonico, P.L. Involvement of nitric oxide in the regulation of gonadotropin-releasing hormone release from the GT1-1 neuronal cell line. Endocrinology 134: 1782–1787, 1994.PubMedCrossRefGoogle Scholar
- Steele, M.K. Effects of angiotensins injected into various brain areas on luteinizing hormone release in female rats. Neuroendocrinology 46: 401–405, 1987.PubMedCrossRefGoogle Scholar
- Steele, M.K. Additive effects of atrial natriuretic peptide and angiotensin II on luteinizing hormone and prolactin release in female rats. Neuroendocrinology 51: 345–350, 1990.PubMedCrossRefGoogle Scholar
- Steele, M.K. The role of brain angiotensin II in the regulation of luteinizing hormone and prolactin secretion. Trends Endocrinol. Metab. 3: 295–301, 1992.PubMedCrossRefGoogle Scholar
- Steele, M.K., Gallo, R.V. and Ganong, W.F. A possible role for the brain renin-angiotensin system in the regulation of LH secretion. Am J Physiol 245:R805–R810, 1983.PubMedGoogle Scholar
- Steele, M.K., Gallo, R.V. and Ganong, W.F. Stimulatory or inhibitory effects of angiotensin II upon LH secretion in ovariectomized rats: A function of gonadal steroids. Neuroendocrinology 40: 210–216, 1985.PubMedCrossRefGoogle Scholar
- Steele, M.K. and Ganong, W.F. Brain renin-angiotensin systems and secretion of luteinizing hormone and prolactin. In: Frontiers in Neuroendocrinology. Volume 9, edited by Ganong, W.F. and Martini, L. New York: Raven Press, 1986, p. 99–113).Google Scholar
- Steele, M.K., McCann, S.M. and Negro-Vilar, A. Modulation by dopamine and estradiol of central effects of angiotensin II on anterior pituitary hormone release. Endocrinology 111: 722–729, 1982.PubMedCrossRefGoogle Scholar
- Steele, M.K., Negro-Vilar, A. and McCann, S.M. Effect of angiotensin II on in vivo and in vitro release of anterior pituitary hormones in the female rat. Endocrinology 109: 893–899, 1981.PubMedCrossRefGoogle Scholar
- Steele, M.K., Stephenson, K.N., Meredith, J.M. and Levine, J.E. Effects of angiotensin II on LHRH release, as measured by in vivo microdialysis of the anterior pituitary gland of conscious rats. Neuroendocrinology 55: 276–281, 1992.PubMedCrossRefGoogle Scholar
- Steger, R.W., Amador, A., Lam, E., Rathert, J., Weis, J. and Smith, M.S. Streptozotocin-induced deficits in sex behavior and neuroendocrine function in male rats. Endocrinology 124: 1737–1743, 1989.PubMedCrossRefGoogle Scholar
- Steger, R.W. and Bartke, A. Temporal sequence of neuroendocrine events associated with the transfer of male golden hamsters from a stimulatory to a nonstimulatory photoperiod. Biol Reprod 44: 76–82, 1991.PubMedCrossRefGoogle Scholar
- Steger, R.W., Bartke, A., Bain, P.A. and Chandrashekar, V. Hyperprolactinemia disrupts neuroendocrine responses of male rats to female conspecifics. Neuroendocrinology 46: 499–503, 1987.PubMedCrossRefGoogle Scholar
- Steger, R.W., Bartke, A., Parkening, T.A., et al. Effects of heterologous growth hormones on hypothalamic and pituitary function in transgenic mice. Neuroendocrinology 53: 365–372, 1991.PubMedCrossRefGoogle Scholar
- Steger, R.W., DePaolo, L.V., Asch, R.H. and Silverman, A.Y. Interactions of delta 9-tetrahydrocannabinol (THC) with hypothalamic neurotransmitters controlling luteinizing hormone and prolactin release. Neuroendocrinology 37: 361–370, 1983.PubMedCrossRefGoogle Scholar
- Steiner, R.A., Bremmer, W.J. and Clifton, D.K. Regulation of LH pulse frequency and amplitude by testosterone in the adult male rat. Endocrinology 111: 2055–2061, 1982.PubMedCrossRefGoogle Scholar
- Toney, T.W., Lookingland, K.J. and Moore, K.E. Role of testosterone in the regulation of tuberoinfundibular dopaminergic neurons in the male rat. Neuroendocrinology 54: 23–29, 1991.PubMedCrossRefGoogle Scholar
- Toney, T.W., Pawsat, D.E., Fleckenstein, A.E., Lookingland, K.J. and Moore, K.E. Evidence that prolactin mediates the stimulatory effects of estrogen on tuberoinfundibular dopamine neurons in female rats. Neuroendocrinology 55: 282–289, 1992.PubMedCrossRefGoogle Scholar
- Tong, Y, Simard, J., Labrie, C., Zhao, H.F., Labrie, F. and Pelletier, G. Inhibitory effect of androgen on estrogen-induced prolactin messenger ribonucleic acid accumulation in the male rat anterior pituitary gland. Endocrinology 125: 1821–1828, 1989.PubMedCrossRefGoogle Scholar
- Van Den Pol, A.N., Wuarin, J-P. and Dudek, F.E. Glutamate, the dominant excitatory transmitter in neuroendocrine regulation. Science 250: 1276–1278, 1990.PubMedCrossRefGoogle Scholar
- Van der Beek, E.M., Van Oudheusden, H.J.C., Buijs, R.M., Van der Donk, H.A., Van den Hurk, R. and Wiegant, V.M. Preferential induction of c-fos immunoreactivity in vasoactive intestinal polypeptide-innervated gonadotropin-releasing hormone neurons during a steroid-induced luteinizing hormone surge in the female rat. Endocrinology 134: 2636–2644, 1994.PubMedCrossRefGoogle Scholar
- Vijayan, E. and McCann, S.M. Re-evaluation of the role of catecholamines in control of catecholamine and prolactin release. Neuroendocrinology 25: 150–157, 1987.CrossRefGoogle Scholar
- Virmani, M.A., Stojilkovic, S.S. and Catt, K.J. Stimulation of luteinizing hormone release by gamma-aminobutyric acid (GABA) agonists: mediation by GABAa-type receptors and activation of chloride and voltage-sensitive calcium channels. Endocrinology 126: 2499–2505, 1990.PubMedCrossRefGoogle Scholar
- Vitale, M.L. and Chiocchio, S.R. Serotonin, a neurotransmitter involved in the regulation of luteinizing hormone release. Endocr. Rev. 14: 480–493, 1993.PubMedGoogle Scholar
- Vitale, M.L., Parisi, M.N., Chiocchio, S.R. and Tramezzani, J.H. Median eminence serotonin involved in the proestrous gonadotropin release. Neuroendocrinology 39: 136–141, 1984.PubMedCrossRefGoogle Scholar
- Voogt, J.L. and Meites, J. Effects of an implant of prolactin in median eminece of pseudopregnant rats on serum and pituitary LH, FSH and prolactin. Endocrinology 88: 286–292, 1971.PubMedCrossRefGoogle Scholar
- Walker, R.F. Quantitative and temporal aspects of serotonin’s facilitatory action on phasic secretion of luteinizing hormone in female rats. Neuroendocrinology 36: 468–474, 1983.PubMedCrossRefGoogle Scholar
- Wanke, I.E. and Rorstad, O.P. Receptors for vasoactive intestinal peptide in rat anterior pituitary glands: Localization of binding to lactotropes. Endocrinology 126: 1981–1988, 1990.PubMedCrossRefGoogle Scholar
- Wehrenberg, W.B., Corder, R. and Gaillard, R.C. A physiological role for neuropeptide Y in regulating the oestrogen/progesterone-induced luteinizing hormone surge in ovariectomized rats. Neuroendocrinology 49: 680–682, 1989.PubMedCrossRefGoogle Scholar
- Weick, R.F., Stobie, K.M. and Noh, K.A. Effect of [4C1-D-Phe6, Leu 17] VIP on the inhibition of LH release by VIP and related peptides in the ovariectomized rat. Neuroendocrinology 56: 646–652, 1992.PubMedCrossRefGoogle Scholar
- Weiner, R.I. and Ganong, W.F. Role of brain monoamines and histamine in regulation of anterior pituitary secretion. Physiol. Rev 58: 905–975, 1978.PubMedGoogle Scholar
- Yen, S.S.C. Neuroendocrine control of hypophyseal function: Physiological and clinical implications. In: Reproductive Endocrinology: Physiology, Pathophysiology and Clinical Management, edited by Yen, S.S.C. and Jaffe, R.B. Philadelphia: W.B. Saunders, 1986, p. 33–74).Google Scholar
- Ying, S.-Y Inhibins, activins and follistatins. J. Steroid Biochem. 33:705–713, 1989.PubMedCrossRefGoogle Scholar