The Adrenal Renin/Angiotensin System

  • G. P. Vinson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 377)


In mammals, the adrenals are paired glands lying anterior to the kidney, having a combined wet weight approximately 0.1%–0.2% of the total body weight. Histologically, the cells of the outer part of the gland, the cortex, which entirely surround the inner medulla, are arranged as three major layers, or zones, organized as concentric shells. These are the zonae glomerulosa, fasciculata and reticularis. The cells of the different zones are generally distinguished by their shape and size, as well as by their arrangement and disposition within the gland. In general, the cells of the glomerulosa, which lies beneath the connective tissue capsule, consists of an arrangment of cells variously described as loops, whorls or baskets. The larger, and more numerous, cells of the zona fasciculata are invariably arranged as centripetally oriented cords, which abut on to the less clearly organised network of cells which form the zona reticularis. The reticularis adjoins the central medulla (Vinson et al. 1992).


Adrenal Cortex Zona Glomerulosa Renin Gene Expression Adrenal Glomerulosa Cell Adrenal Zona Glomerulosa 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • G. P. Vinson
    • 1
  1. 1.Department of BiochemistryQueen Mary & Westfield CollegeLondonUK

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