Angiotensin II Receptors

Structural and Functional Considerations
  • Robert C. Speth
  • Steven M. Thompson
  • Susan J. Johns
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 377)


The renin-angiotensin system (RAS) profoundly influences cardiovascular function. The system likely evolved to meet the need to preserve cardiovascular function in response to stressors such as hemorrhage, dehydration and dietary sodium deficiency. However, the RAS can also induce pathological changes, either in response to renal dysfunction or relatively uncharacterized alterations in organs containing local renin-angiotensin systems. From a medical viewpoint, hypertension is the pathological alteration induced by the RAS of greatest interest. Sustained high blood pressure takes a toll on the cardiovascular system and secondarily on the organ systems it perfuses, e.g., high fluid pressure leads to cardiac hypertrophy and valvular insufficiency, damage to vascular endothelium, generation of thrombi, and rupture of vessel walls leading to hemorrhagic and ischaemic damage within various organs of the body.


Receptor Subtype Selective Antagonist Receptor Binding Site Human Uterus Transmembrane Span Domain 
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  1. Aguilera, G. and K. Catt, 1981, Circ. Res. 49, 751.PubMedCrossRefGoogle Scholar
  2. Aiyar, N., E. Baker, H.L. Wu, P. Nambi, R.M. Edwards, J.J. Trill, C. Ellis and D.J. Bergsma, 1994, Mol. Cell Biochem. 131, 75.PubMedCrossRefGoogle Scholar
  3. Allen, A.M., G. Paxinos, K.F. Song and F.A.O. Mendelsohn, (1992) In: Bjorklund, A., T. Hokfelt and M.J. Kuhar, (Eds.), Handbook of Chemical Neuroanatomy, Vol 11, Neuropeptide Receptors in the CNS (Elsevier, Amsterdam) p. 1.Google Scholar
  4. Altschul, S.F., W. Gish, W. Miller, E.W. Myers and D.J. Lipman, 1990, J. Molec. Biol. 215, 403.PubMedGoogle Scholar
  5. Anand-Srivastava, M.B., 1989, Biochem. Pharmacol. 38, 489.PubMedCrossRefGoogle Scholar
  6. Angles d’Auriac, G., M. Baudouin and P. Meyer, 1972, Circ. Res. 30, II.Google Scholar
  7. Badoer, E., B.J. Oldfield and M.J. McKinley, 1993, Neurosci. Lett. 159: 151.PubMedCrossRefGoogle Scholar
  8. Baker, K.M., C.P. Campanile, G.J. Trachte and M.J. Peach, 1984, Circ. Res. 54: 286.PubMedCrossRefGoogle Scholar
  9. Baker, K.M., G.W. Booz and D.E. Dostal, 1994, Ann. Rev. Physiol. 54: 227.CrossRefGoogle Scholar
  10. Baker, P.N., F.B. Pipkin and E.M. Symonds, 1992, Am. J. Obstet. Gynecol. 166: 255.PubMedCrossRefGoogle Scholar
  11. Baker, P.N. and F.B. Pipkin, 1994, Am. J. Obstet. Gynecol. 170: 1301.PubMedCrossRefGoogle Scholar
  12. Baudouin, M., P. Meyer and M. Worcel, 1971, Biochem. Biophys. Res. Commun. 42: 434.PubMedCrossRefGoogle Scholar
  13. Baxter, C, J. Horvath, G. Duggin and D. Tiller, 1979, Clin. Sci. 57: 111.s.Google Scholar
  14. Bell, J.B.G., J.F. Tait, S.A.S. Tait, G.D. Barnes and B.L. Brown, 1981, Endocrinology 91, 145.CrossRefGoogle Scholar
  15. Bennett, J.P. Jr. and S.H. Snyder, 1976, J. Biol. Chem. 251: 7423.PubMedGoogle Scholar
  16. Bennett, J.P. Jr. and S.H. Snyder, 1980, Eur. J. Pharmacol. 67: 11.PubMedCrossRefGoogle Scholar
  17. Bergsma, D.J., C. Ellis, C. Kumar, P. Nuthulaganti, H. Kersten, N. Elshourbagy, E. Griffin, J.M. Stadel and N. Aiyar, 1992, Biochem. Biophys. Res. Commun. 183: 989.PubMedCrossRefGoogle Scholar
  18. Bergsma, D.J., C. Ellis, P.R. Nuthulaganti, P. Nambi, K. Scaife, C. Kumar and N. Aiyar, 1993, Mol. Pharmacol. 44: 277.PubMedGoogle Scholar
  19. Bergwitz, C., S. Madoff, A.B. Abou-Samra and H. Juppner, 1991, Biochem. Biophys. Res. Commun. 179: 1391.PubMedCrossRefGoogle Scholar
  20. Bottari, S., I.N. King, S. Reichlin, I. Dahlstroem, N. Lydon and M. de Gasparo, 1992, Biochem. Biophys. Res. Commun. 183: 206.PubMedCrossRefGoogle Scholar
  21. Bottari, S.P., V. Taylor, I.N. King, Y. Bogdal, S. Whitebread and M. de Gasparo, 1991, Eur. J. Pharmacol. 207: 157.PubMedCrossRefGoogle Scholar
  22. Brechler, V, P.W. Jones, N. Levens, M. de Gasparo and S.P. Bottari, 1993, Regul. Pept. 44: 207.PubMedCrossRefGoogle Scholar
  23. Brown, G.P. and J.G. Douglas, 1983, Endocrinology 112, 2007.PubMedCrossRefGoogle Scholar
  24. Buisson, B., S.P. Bottari, M. de Gasparo, N. Gallo-Payet and M.D. Payet, 1992, FEBS Lett. 309: 161.PubMedCrossRefGoogle Scholar
  25. Bumpus, F.M., R.R. Smeby, I.H. Page and P.A. Khairallah, 1964, Canad. Med. Assoc. J. 90: 190.PubMedGoogle Scholar
  26. Bumpus, F.M. and et al., 1991, Hypertension 17, 720.PubMedCrossRefGoogle Scholar
  27. Campanile, C.P., J.K. Crane, M.J. Peach and J.C. Garrison, 1982, J. Biol. Chem. 257: 4951.PubMedGoogle Scholar
  28. Capponi, A.M. and [K.J. Catt, 1979, J. Biol. Chem. 254: 5120.PubMedGoogle Scholar
  29. Cardenas-Tanus, R.J., J. Huerta-Bahena and J.A. Garcia-Sainz, 1982, FEBS Lett. 143: 1.PubMedCrossRefGoogle Scholar
  30. Castren, E., M. Kurihara and J.M. Saavedra, 1987, Peptides 8, 737.PubMedCrossRefGoogle Scholar
  31. Chaki, S. and T. Inagami, 1992, Biochem. Biophys. Res. Commun. 182: 388.PubMedCrossRefGoogle Scholar
  32. Chaki, S. and T. Inagami, 1993, Molecular Pharmacology 43, 603.PubMedGoogle Scholar
  33. Chansel, D., L. Badre, S. Czekalski, S. Vandermeersch, J. Cambar and R. Ardaillou, 1993, J. Pharmacol. Exp. Ther. 265: 1534.PubMedGoogle Scholar
  34. Chappell, M.C., D.I. Diz and D.W. Jacobsen, 1992, Peptides. 13: 313.PubMedCrossRefGoogle Scholar
  35. Chen, F.M., R. Hawkins and M.P. Printz, 1982, Exp. Brain Res. Suppl. 40: 157.CrossRefGoogle Scholar
  36. Chen, F.M. and M.P. Printz, 1983, Endocrinology 113, 1503.PubMedCrossRefGoogle Scholar
  37. Chiu, A.T., W.F. Herblin, D.E. McCall, R.J. Ardecky, D.J. Carini, J.V. Duncia, L.J. Pease, P.C. Wong, R.R. Wexler, A.L. Johnson and P.B.M.W.M. Timmermans, 1989a, Biochem. Biophys. Res. Commun. 165, 196.PubMedCrossRefGoogle Scholar
  38. Chiu, A.T., D.E. McCall, T.T. Nguyen, D.J. Carini, J.V. Duncia, W.F. Herblin, R.T. Uyeda, P.C. Wong, R.R. Wexler, A.L. Johnson and P.B.M.W.M. Timmermans, 1989b, Eur. J. Pharmacol. 170, 117.PubMedCrossRefGoogle Scholar
  39. Chiu, A.T., J. Dunscomb, J. Kosierowski, C.R. Burton, L.D. Santomenna, M.H. Corjay and P. Benfield, 1993, Biochem. Biophys. Res. Commun. 197: 440.PubMedCrossRefGoogle Scholar
  40. Chua, C.C., C.A. Diglio, B.B. Siu and B.H. Chua, 1994, Biochim. Biophys. Acta 1223, 141.PubMedCrossRefGoogle Scholar
  41. Coleman, J.K.M., B. Ong, M. Sardinia, J.W. Harding and J.W. Wright, 1992, FASEB J. 6, A981. (Abstract).Google Scholar
  42. Cox, H.M., K.A. Munday and J.A. Poat, 1983, Br. J. Pharmacol. 79: 63.PubMedCrossRefGoogle Scholar
  43. Cox, H.M., K.A. Munday and J.A. Poat, 1986, Brit. J. Pharmacol. 87: 201.CrossRefGoogle Scholar
  44. Crabos, M., S. Bertschin, F.R. Buhler, H. Rogg, D. Evequoz, M. Eberhard and P. Erne, 1993, J. Hypertens. Suppl. 11 Suppl 5, S230.Google Scholar
  45. Crane, J.K., C.P. Campanile and J.C Garrison, 1982, J. Biol. Chem. 257: 4959.PubMedGoogle Scholar
  46. Creba, J.A., C.P. Downes, P.T. Hawkins, G. Brewster, R.H. Michell and C.J. Kirk, 1983, Biochem. J. 212: 733.PubMedGoogle Scholar
  47. de Oliveira, A.M., M. Viswanathan, F.M. Heemskerk, F.M. Correa and J.M. Saavedra, 1994, Biochem. Biophys. Res. Commun. 200, 1049.PubMedCrossRefGoogle Scholar
  48. Dekanski, J., 1954, Brit. J. Pharmacol. 9: 187.PubMedGoogle Scholar
  49. Devynck, M-A., M-G. Pernollet, P. Meyer, S. Fermandjian and P. Fromageot, 1973, Nature New Biol. 245: 55.PubMedGoogle Scholar
  50. Devynck, M.A., B. Rouzaire-Dubois, E. Chevillotte and P. Meyer, 1976, Eur. J. Pharmacol. 40: 27.PubMedCrossRefGoogle Scholar
  51. Devynck, M.A., M.G. Pernollet, P.G. Matthews, M.C. Khosla, F.M. Bumpus and P. Meyer, 1977, Proc. Natl. Acad. Sci. USA 74, 4029.PubMedCrossRefGoogle Scholar
  52. Ding, Y.A., C.J. Kenyon and P.F. Semple, 1984, Clin. Sci. 66: 725.PubMedGoogle Scholar
  53. Dourish, C, J.A. Duggan and R.J.A. Banks, 1992, Eur. J. Pharmacol. 211: 113.PubMedCrossRefGoogle Scholar
  54. Dudley, D.T., R.L. Panek, T.C. Major, G.H. Lu, R.F. Bruns, B.A. Klinkefus, J.C. Hodges and R.E. Weishaar, 1990, Mol. Pharmacol. 38: 370.PubMedGoogle Scholar
  55. Duggan, K.A., F.A.O. Mendelsohn and N.R. Levens, 1989, Am. J. Physiol. 257, G504.PubMedGoogle Scholar
  56. Duncia, J.V., D.J. Carini, A.T. Chiu, A.L. Johnson, W.A. Price, P.C. Wong, R.R. Wexler and P.B. Timmermans, 1992a, Med. Res. Rev. 12, 149.PubMedCrossRefGoogle Scholar
  57. Dzau, V.J., G.H. Gibbons and R.E. Pratt, 1991, Hypertension 18, II100.PubMedCrossRefGoogle Scholar
  58. Elton, T.S., C.C. Stephan, G.R. Taylor, M.G. Kimball, M.M. Martin, J.N. Durand and S. Oparil, 1992, Biochem. Biophys. Res. Commun. 184: 1067.PubMedCrossRefGoogle Scholar
  59. Entzeroth, M. and S. Hadamovsky, 1991, Eur. J. Pharmacol. 206: 237.PubMedCrossRefGoogle Scholar
  60. Ernsberger, P., J. Zhou and T.H. Damon, 1992, Am. J. Physiol. 263, F411.PubMedGoogle Scholar
  61. Farese, R.V., R.E. Larson and J.S. Davis, 1984, Endocrinology 114, 302.PubMedCrossRefGoogle Scholar
  62. Felsenstein, J., 1993, PHYLIP Manual, Version 3.5 (Univ Washington, Seattle, WA)Google Scholar
  63. Fleisch, J.H., M. Krzan and E. Titus, 1973, Circ. Res. 33: 284.PubMedCrossRefGoogle Scholar
  64. Furuta, H., D.F. Guo, T. Inagami and N. Iwai, 1992, Biochem. Biophys. Res. Commun. 182: 1094.CrossRefGoogle Scholar
  65. Gehlert, D.R., R.C. Speth and J.K. Wamsley, 1984a, Peptides 5, 1043.PubMedCrossRefGoogle Scholar
  66. Gehlert, D.R., R.C. Speth and J.K. Wamsley, 1984b, Eur. J. Pharmacol. 98, 145.PubMedCrossRefGoogle Scholar
  67. Gehlert, D.R., R.C. Speth and J.K. Wamsley, 1986, Neuroscience 18, 837.PubMedCrossRefGoogle Scholar
  68. Gehlert, D.R., S.L. Gackenheimer and D.A. Schober, 1991, Neuroscience. 44: 501.PubMedCrossRefGoogle Scholar
  69. Genetics Computer Group, 1994, Program Manual for the Wisconsin Package, Version beta 8 (Genetics Computer Group, Madison, WI).Google Scholar
  70. Glossmann, H., A. Baukal and K.J. Catt, 1974a, J. Biol. Chem. 249, 664.PubMedGoogle Scholar
  71. Glossmann, H., A.J. Baukal and K.J. Catt, 1974b, J. Biol. Chem. 249, 825.PubMedGoogle Scholar
  72. Goodfriend, T.L. and S.-Y. Lin, 1970, Circ. Res. 26 (Suppl I), I.Google Scholar
  73. Grady, E.F., L.A. Sechi, C.A. Griffin, M. Schambelan and J.E. Kalinyak, 1991, J. Clin. Invest. 88: 921.PubMedCrossRefGoogle Scholar
  74. Grove, K.L., R.C. Speth and C.S. Zamora, (1991) Renin-angiotensin system activity in male reproductive organs. In: Johnston, C.A. and C.D. Barnes, (Eds.), Brain-Gut Peptides and Reproductive Function (CRC Press, Boca Raton) p. 43.Google Scholar
  75. Grove, K.L. and R.C. Speth, 1993, Biochem. Pharmacol. 46: 1653.PubMedCrossRefGoogle Scholar
  76. Gunther, S., M.A. Gimbrone Jr. and R.W. Alexander, 1980, Circ. Res. 47: 278.PubMedCrossRefGoogle Scholar
  77. Gunther, S., 1984, J. Biol. Chem. 259: 7622.PubMedGoogle Scholar
  78. Gyurko, R., B. Kimura, P. Kurian, F.T. Crews and M.I. Phillips, 1992, Biochem. Biophys. Res. Commun. 186: 285.PubMedCrossRefGoogle Scholar
  79. Hahn, A.W., U. Jonas, F.R. Buehler and T.J. Resink, 1993, Biochem. Biophys. Res. Commun. 192: 1260.PubMedCrossRefGoogle Scholar
  80. Harding, J.W., L.P. Stone and J.W. Wright, 1981, Brain Res. 205: 265.PubMedCrossRefGoogle Scholar
  81. Hauger, R.L., G. Aguilera, A.J. Baukal and K.J. Catt, 1982, Mol. Cell Endocrinol. 25: 203.PubMedCrossRefGoogle Scholar
  82. Henikoff, S. and J.G. Henikoff, 1992, Proc. Natl. Acad. Sci. USA 89, 10915.PubMedCrossRefGoogle Scholar
  83. Hess, J.F., J.A. Borkowski, G.S. Young, C.D. Strader and R.W. Ransom, 1992, Biochem. Biophys. Res. Commun. 184: 260.PubMedCrossRefGoogle Scholar
  84. Ishizaki, H. and M. Ohtawa, 1994, Biochem. Pharmacol. 48: 201.PubMedCrossRefGoogle Scholar
  85. Iwai, N. and T. Inagami, 1992, FEBS Lett. 298: 257.PubMedCrossRefGoogle Scholar
  86. Jaiswal, N., D.I. Diz, E.A. Tallant, M.C Khosla and C.M. Ferrario, 1991, Am. J. Hypertens. 4: 228.PubMedCrossRefGoogle Scholar
  87. Jard, S., B. Cantau and K.H. Jakobs, 1981, J. Biol. Chem. 256: 2603.PubMedGoogle Scholar
  88. Ji, H., K. Sandberg and K.J. Catt, 1991, Molecular Pharmacology 39, 120.PubMedGoogle Scholar
  89. Ji, H., K. Sandberg, Y. Zhang and K.J. Catt, 1993, Biochem. Biophys. Res. Commun. 194: 756.PubMedCrossRefGoogle Scholar
  90. Jones, C, M.A. Millan, F. Naftolin and G. Aguilera, 1989, Peptides 10, 459.PubMedCrossRefGoogle Scholar
  91. Kakar, S.S., J.C Sellers, D.C Devor, L.C Musgrove and J.D. Neill, 1992, Biochem. Biophys. Res. Commun. 183: 1090.PubMedCrossRefGoogle Scholar
  92. Kambayashi, Y, S. Bardhan, K. Takahashi, S. Tsuzuki, H. Inui, T. Hamakubo and T. Inagami, 1993, J. Biol. Chem. 268: 24543.PubMedGoogle Scholar
  93. Kang, J., C. Sumners and P. Posner, 1992, Brain Res. 580: 317.PubMedCrossRefGoogle Scholar
  94. Kawahara, Y, M. Sunako, T. Tsuda, H. Fukuzaki, Y. Fukumoto and Y Takai, 1988, Biochem. Biophys. Res. Commun. 150: 52.PubMedCrossRefGoogle Scholar
  95. Kemp, B.E. and R.B. Pearson, 1990, Trends Biochem. Sci. 15: 342.PubMedCrossRefGoogle Scholar
  96. Keppens, S., H. De Wulf, P. Clauser, S. Jard and J-L. Morgat, 1982, Biochem. J. 208: 809.PubMedGoogle Scholar
  97. Khairallah, P.A., A. Toth and F.M. Bumpus, 1970, J. Med. Chem. 13: 181.PubMedCrossRefGoogle Scholar
  98. Khairallah, P.A. and R.R. Smeby, (1974) Bioassay of angiotensin. In: Page, I.H. and F.M. Bumpus, (Eds.), Handbook of Experimental Pharmacology, XXXVII (Springer-Verlag, New York) p. 227.Google Scholar
  99. Khanum, A. and M.L. Dufau, 1988, Journal of Biological Chemistry 263, 5070.PubMedGoogle Scholar
  100. Khosla, M.C, R.R. Smeby and F.M. Bumpus, (1974) Structure-activity relationship in angiotensin II analogs. In: Page, I.H. and F.M. Bumpus, (Eds.), Handbook of Experimental Pharmacology, Vol. 37, Angiotensin (Springer-Verlag Berlin), p. 126.Google Scholar
  101. Kleinen, H.D., W.R. Baker and H.H. Stein, 1991, Adv. Pharmacol. 22: 207.CrossRefGoogle Scholar
  102. Koibuchi, Y, W.S. Lee, G.H. Gibbons and R.E. Pratt, 1993, Hypertension 21, 1046.PubMedCrossRefGoogle Scholar
  103. Kojima, I., K. Kojima, D. Kreutter and H. Rasmussen, 1984, J. Biol. Chem. 259: 14448.PubMedGoogle Scholar
  104. Kojima, I., K. Kojima and H. Rasmussen, 1985, J. Biol. Chem. 260: 9177.PubMedGoogle Scholar
  105. Konishi, H., S. Kuroda, Y. Inada and Y. Fujisawa, 1994, Biochem. Biophys. Res. Commun. 199: 467.PubMedCrossRefGoogle Scholar
  106. LaFontaine, J.J., M.P. Nivez and R. Ardaillou, 1979, Clin. Sci. 56: 33.PubMedGoogle Scholar
  107. Lin, S.-Y and T.L. Goodfriend, 1970, Am. J. Physiol. 213: 1319.Google Scholar
  108. Lu, X.-Y, K.L. Grove and R.C. Speth, 1993, FASEB J. 7: 827. (Abstract)Google Scholar
  109. Lu, X.-Y, K.L. Grove, W. Zhang and R.C. Speth, 1995, Endocrine In press.Google Scholar
  110. Makarious, M., M. Pawlak, L.V.A.U.T. Campbell, K. Duggan, J.A. Charlesworth and G.J. Macdonald, 1993, Eur.J. Clin. Invest. 23: 517.PubMedCrossRefGoogle Scholar
  111. Mann, J.F., J. Sis and E. Ritz, 1985, J. Hypertens. 3: 131.PubMedCrossRefGoogle Scholar
  112. Marshall, G.R., W. Vine and P. Needleman, 1970, Proc. Natl. Acad. Sci. USA 67, 1624.PubMedCrossRefGoogle Scholar
  113. Mauzy, CA., O. Hwang, A.M. Egloff, L.-H. Wu and F.-Z. Chung, 1992, Biochem. Biophys. Res. Commun. 186: 277.PubMedCrossRefGoogle Scholar
  114. Mendelsohn, F.A.O., G. Aguilera, J.M. Saavedra, R. Quirion and K.J. Catt, 1983, Clin. Exp. Hypertens. A5, 1081.CrossRefGoogle Scholar
  115. Mendelsohn, F.A.O., R. Quirion, J.M. Saavedra, G. Aguilera and K.J. Catt, 1984, Proc. Natl. Acad. Sci. USA 81, 1575.PubMedCrossRefGoogle Scholar
  116. Millan, M.A., P. Carvallo, S-I. Izumi, S. Zemel, K.J. Catt and G. Aguilera, 1989, Science 244, 1340.PubMedCrossRefGoogle Scholar
  117. Miller-Wing, A.V., J.M. Hanesworth, M.F. Sardinia, K.L. Hall, J.W. Wright, R.C. Speth, K.L. Grove and J.W. Harding, 1993, J. Pharmacol. Exp. Ther. 266: 1718.PubMedGoogle Scholar
  118. Moore, T.J., T. Taylor and G.H. Williams, 1984, J. Clin. Endocrinol. Metab. 58: 778.PubMedCrossRefGoogle Scholar
  119. Morgan, H.E. and K.M. Baker, 1991, Circulation 83, 13.PubMedCrossRefGoogle Scholar
  120. Mukherjee, A., P. Kulkarni, S.M. McCann and A. Negro-Vilar, 1982a, Endocrinology 110, 665.PubMedCrossRefGoogle Scholar
  121. Mukherjee, A., P.V. Kulkarni, Z. Haghani and J.L. Sutko, 1982b, Biochem. Biophys. Res. Commun. 105, 575.PubMedCrossRefGoogle Scholar
  122. Mukoyama, M., M. Nakajima, M. Horiuchi, H. Sasamura, R.E. Pratt and V.J. Dzau, 1993, J. Biol. Chem. 268: 24539.PubMedGoogle Scholar
  123. Murphy, T.J., R.W. Alexander, K.K. Griendling, M.S. Runge and K.E. Bernstein, 1991, Nature 351, 233.PubMedCrossRefGoogle Scholar
  124. Murphy, T.J., K. Takeuchi and R.W. Alexander, 1992, Am. J. Hypertens. 5: 236.S.Google Scholar
  125. Murphy, T.J., Y Nakamura, K. Takeuchi and R.W. Alexander, 1993, Mol. Pharmacol. 44: 1.PubMedGoogle Scholar
  126. Naftilan, A.J., R.E. Pratt and V.J. Dzau, 1989a, J. Clin. Invest. 83, 1419.PubMedCrossRefGoogle Scholar
  127. Naftilan, A.J., R.E. Pratt, C.S. Eldridge, H.L. Lin and V.J. Dzau, 1989b, Hypertension 13, 706.PubMedCrossRefGoogle Scholar
  128. Naftilan, A.J., G.K. Gilliland, C.S. Eldridge and A.S. Kraft, 1990, Mol. Cell Biol. 10: 5536.PubMedGoogle Scholar
  129. Neote, K., D. DiGregorio, J.Y. Mak, R. Horuk and T.J. Schall, 1993, Cell 72, 415.PubMedCrossRefGoogle Scholar
  130. Neyses, L., R. Locher, M. Wehling, H. Pech, W. Tenschert and W. Vetter, 1984, Clin. Sci. 66: 605.PubMedGoogle Scholar
  131. Ohlstein, E.H., M. Gellai, D.P. Brooks, L. Vickery, J. Jugus, A. Sulpizio, R.R. Ruffolo, Jr., J. Weinstock and R.M. Edwards, 1992, J. Pharmacol. Exp. Ther. 262: 595.PubMedGoogle Scholar
  132. Ohnishi, J., M. Ishido, T. Shabata and et al, 1992, Biochem. Biophys. Res. Commun. 186: 1094.PubMedCrossRefGoogle Scholar
  133. Ohyama, K., Y. Yamano, S. Chaki, T. Kondo and T. Inagami, 1992, Biochem. Biophys. Res. Commun. 189: 677.PubMedCrossRefGoogle Scholar
  134. Oldfield, B.J., E. Badoer, D.K. Hards and M.J. McKinley, 1994, Neuroscience. 60: 255.PubMedCrossRefGoogle Scholar
  135. Page, I.H. and O.M. Helmer, 1940, J. Exp. Med. 71: 29.PubMedCrossRefGoogle Scholar
  136. Peach, M.J., (1988) Actions of angiotensin on elements of the vascular wall and myocardium. In: Harding, J.W., J.W. Wright, R.C. Speth and CD. Barnes, (Eds.), Angiotensin and Blood Pressure Regulation (Academic Press, New York, NY) p. 35.Google Scholar
  137. Peart, W.S., 1955, Biochem. J. 59: 300.PubMedGoogle Scholar
  138. Raizada, M.K., J.W. Yang, M.I. Phillips and R.E. Fellows, 1981, Brain Res. 207: 343.PubMedCrossRefGoogle Scholar
  139. Regoli, D., W.K. Park and F. Rioux, 1974, Pharmacol. Rev. 26: 69.PubMedGoogle Scholar
  140. Rogers, T.B., 1984, J. Biol. Chem. 259: 8106.PubMedGoogle Scholar
  141. Rouzaire-Dubois, B., M.A. Devynck, E. Chevillotte and P. Meyer, 1975, FEBS Lett. 55: 168.PubMedCrossRefGoogle Scholar
  142. Rowe, B.P., K.L. Grove, D.L. Saylor and R.C. Speth, 1990, Eur. J. Pharmacol. 186: 339.PubMedCrossRefGoogle Scholar
  143. Rowe, B.P., D.L. Saylor and R.C. Speth, 1992, Neuroendocrinology 55, 563.PubMedCrossRefGoogle Scholar
  144. Rowland, N.E., B.-H. Li, A.K. Rozelle, M.J. Fregly, M. Garcia and G.C. Smith, 1993, Brain Res. Bull. 33: 427.CrossRefGoogle Scholar
  145. Rowland, N.E. and M.J. Fregly, 1993, Brain Res. Bull. 32: 391.PubMedCrossRefGoogle Scholar
  146. Sakuta, H., M. Sekiguchi, K. Okamoto and Y Sakai, 1991, Eur. J. Pharmacol. 208: 31.PubMedCrossRefGoogle Scholar
  147. Sandberg, K., H. Ji, A.J. Clark, H. Shapira and K.J. Catt, 1992, J. Biol. Chem. 267: 9455.PubMedGoogle Scholar
  148. Sandberg, K., 1994, Trends Endocrinol. Metab. 5: 28.PubMedCrossRefGoogle Scholar
  149. Sasaki, K., Y Yamano, S. Bardhan, N. Iwai, J.J. Murray, M. Hasegawa, Y. Matsuda and T. Inagami, 1991, Nature 351, 230.PubMedCrossRefGoogle Scholar
  150. Sasamura, H., L. Hein, J.E. Krieger, R.E. Pratt, B.K. Kobilka and V.J. Dzau, 1992, Biochem. Biophys. Res. Commun. 185: 253.PubMedCrossRefGoogle Scholar
  151. Savarese, T.M. and C.M. Fraser, 1992, Biochem. J. 283: 1.PubMedGoogle Scholar
  152. Scheuer, D.A. and M.H. Perrone, 1993, Am. J. Physiol. 264, R917.PubMedGoogle Scholar
  153. Schiavone, M.T., R.A. Santos, K.B. Brosnihan, M.C. Khosla and C.M. Ferrario, 1988, Proc. Natl. Acad. Sci. USA 85, 4095.PubMedCrossRefGoogle Scholar
  154. Sirett, N.E., A.S. McLean, J.J. Bray and J.I. Hubbard, 1977, Brain Res. 122: 299.PubMedCrossRefGoogle Scholar
  155. Song, K., A.M. Allen, G. Paxinos and F.A.O. Mendelsohn, 1991, Clin. Exp. Pharmacol. Physiol. 18: 93.PubMedCrossRefGoogle Scholar
  156. Song, K., A.M. Allen, G. Paxinos and F.A.O. Mendelsohn, 1992, J. Comp. Neurol. 316: 467.PubMedCrossRefGoogle Scholar
  157. Speth, R.C, M.B. Vallotton, J.K. Wamsley, M.C. Khosla, C.L. Chernicky, F.M. Bumpus and CM. Ferrario, 1984, Clin. Exp. Hypertens. 6: 1749.CrossRefGoogle Scholar
  158. Speth, R.C, F.M. Bumpus and A. Husain, 1986, Eur. J. Pharmacol. 130: 351.PubMedCrossRefGoogle Scholar
  159. Speth, R.C, K.L. Grove and CS. Zamora, (1991a) Renin-angiotensin system activity in female reproductive organs. In: Johnston, C.A. and CD. Barnes, (Eds.), Brain-Gut Peptides and Reproductive Function (CRC Press, Boca Raton) p. 21.Google Scholar
  160. Speth, R.C, B.P. Rowe, K.L. Grove, M.R. Carter and D.L. Saylor, 1991b, Brain Res. 548, 1.PubMedCrossRefGoogle Scholar
  161. Speth, R.C, 1993, Regul. Pept. 44: 189.PubMedCrossRefGoogle Scholar
  162. Speth, R.C and S.I. Harik, 1985, Proc. Natl. Acad. Sci. USA 82, 6340.PubMedCrossRefGoogle Scholar
  163. Speth, R.C. and K.H. Kim, 1990, Biochem. Biophys. Res. Commun. 169: 997.PubMedCrossRefGoogle Scholar
  164. Sraer, J.D., J. Sraer, R. Ardaillou and O. Mimoune, 1974, Kidney Int. 6: 241.PubMedCrossRefGoogle Scholar
  165. Stephenson, K.N. and M.K. Steele, 1992, J. Neuroendo. 4: 441.CrossRefGoogle Scholar
  166. Stromberg, C, L. Naveri and J.M. Saavedra, 1992, Neuroreport 3, 703.PubMedCrossRefGoogle Scholar
  167. Sumners, C, W. Tang, B. Zelezna and M.K. Raizada, 1991, Proc. Natl. Acad. Sci. USA 88, 7567.PubMedCrossRefGoogle Scholar
  168. Takayanagi, R., K. Ohnaka, Y. Sakai, R. Nakao, T. Yanase, M. Haji, T. Inagami, H. Furuta, D.F. Gou and M. Nakamuta, 1992, Biochem. Biophys. Res. Commun. 183: 910.PubMedCrossRefGoogle Scholar
  169. Tallant, E.A., D.I. Diz, M.C Khosla and CM. Ferrario, 1991, Hypertension 17, 1135.PubMedCrossRefGoogle Scholar
  170. Timmermans, P.B., P.C. Wong, A.T. Chiu, W.F. Herblin, P. Benfield, D.J. Carini, RJ. Lee, R.R. Wexler, J.A. Saye and R.D. Smith, 1993, Pharmacol. Rev. 45: 205.PubMedGoogle Scholar
  171. Tsutsumi, K., C. Stromberg, M. Viswanathan and J.M. Saavedra, 1991, Endocrinology 129, 1075.PubMedCrossRefGoogle Scholar
  172. Tsutsumi, K. and J.M. Saavedra, 1992, Mol. Pharmacol. 41: 290.PubMedGoogle Scholar
  173. Tsuzuki, S., T. Ichiki, H. Nakakubo, Y. Kitami, D.F. Guo, H. Shirai and T. Inagami, 1994, Biochem. Biophys. Res. Commun. 200: 1449.PubMedCrossRefGoogle Scholar
  174. Viswanathan, M. and J.M. Saavedra, 1992, Peptides. 13: 783.PubMedCrossRefGoogle Scholar
  175. Volicer, L. and S. Hynie, 1971, Eur. J. Pharmacol. 15: 214.PubMedCrossRefGoogle Scholar
  176. Webb, M.L., E.C-K. Liu, R.B. Cohen, A. Hedberg, E.A. Bogosian, H. Monshizadegan, C Molloy, R. Serafĭno, S. Moreland, TJ. Murphy and K.E.J. Dickinson, 1992, Peptides 13, 499.PubMedCrossRefGoogle Scholar
  177. Webb, M.L., H. Monshizadegan, K.E.J. Dickinson, R. Serafino, S. Moreland, I. Michel, S.M. Seiler and T.J. Murphy, 1993a, Regul. Pept. 44, 131.PubMedCrossRefGoogle Scholar
  178. Weinstock, J.V. and J.T. Kassab, 1984, J. Immunol. 132: 2598.PubMedGoogle Scholar
  179. Westerman, R., 1991, Prettybox (Purdue Univ, Lafayette, IN).Google Scholar
  180. Whitebread, S., M. Mele, B. Kamber and M. de Gasparo, 1989, Biochem. Biophys. Res. Commun. 163: 284.PubMedCrossRefGoogle Scholar
  181. Whitebread, S., J. Pfeilschifter, H. Ramjoue and M. de Gasparo, 1993, Regul. Pept. 44: 233.PubMedCrossRefGoogle Scholar
  182. Widdowson, P.S., A. Renouard and J.-P. Vilaine, 1993, Peptides 14, 829.PubMedCrossRefGoogle Scholar
  183. Wong, P.C., D.D. Christ and P.B. Timmermans, 1992, Eur. J. Pharmacol. 220: 267.PubMedCrossRefGoogle Scholar
  184. Woodcock, E.A. and C.I. Johnston, 1982, Endocrinology 111, 1687.PubMedCrossRefGoogle Scholar
  185. Wright, G.B., R.W. Alexander, L.S. Ekstein and M.A. Jr. Gimbrone, 1983, Mol. Pharmacol. 24: 213.PubMedGoogle Scholar
  186. Wright, J.W., A.V. Miller-Wing, M.J. Shaffer, C Higginson, D.E. Wright, J.M. Hanesworth and J.W. Harding, 1993, Brain Res. Bull. 32: 497.PubMedCrossRefGoogle Scholar
  187. Wright, J.W. and J.W. Harding, 1994, Neurosci. Biobehav. Rev. 18: 21.PubMedCrossRefGoogle Scholar
  188. Yamano, Y, K. Ohyama, S. Chaki, D.-F. Guo and T. Inagami, 1992, Biochem. Biophys. Res. Commun. 187: 1426.PubMedCrossRefGoogle Scholar
  189. Yoshida, H., J. Kakuchi, D.-F. Guo, H. Furuta, N. Iwai, R. van der Meer-de Jong, T. Inagami and I. Ichikawa, 1992, Biochem. Biophys. Res. Commun. 186: 1042.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Robert C. Speth
    • 1
  • Steven M. Thompson
    • 2
  • Susan J. Johns
    • 2
  1. 1.Department of Veterinary and Comparative Anatomy, Pharmacology and PhysiologyWashington State UniversityPullmanUSA
  2. 2.VADMS CenterWashington State UniversityPullmanUSA

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