Lipotrope Deficiency and Persistent Changes in DNA Methylation

Lipotrope Deficiency and DNA Methylation
  • Judith K. Christman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 354)


Dietary deficiency of lipotropes (choline, methionine, folate, vitamin B12) has long been associated with increased incidence of tumors. Copeland and Salmon first reported that long-term feeding of choline deficient diet increased incidence of tumor in the liver and other organs of the rat almost 50 years ago1. Subsequent studies demonstrated that the peanut meal they used in the diet was contaminated with aflatoxin2, and it was soon established that a variety of different diets deficient in choline and/or other lipotropes acted to promote carcinogen induced tumor development in the liver and other organs3–10. Later, through feeding of amino-acid defined diets tested for absence of exogenous carcinogens11, it was possible to prove that lipotrope deficiency alone was sufficient to cause development of tumors in the liver. However, the spectrum of tumors induced by lipotrope deficiency was much narrower than that seen in lipotrope-deficient animals treated with carcinogen and the diet actually seemed to inhibit appearance of some spontaneously arising tumors11


Persistent Change Peanut Meal Liver Carcinogenesis CCGG Site Choline Deficiency 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Judith K. Christman
    • 1
  1. 1.Department of Biochemistry and Molecular BiologyUniversity of Nebraska Medical CenterOmahaUSA

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