Effect of Dietary Fatty Acids on Gene Expression in Breast Cells

  • Z. Ronai
  • J. Tillotson
  • L. Cohen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 354)


At present there is considerable controversy surrounding the role of dietary fat in breast cancer (1,2). Epidemiological, anthropological, and animal model studies support the concept that high fat intake increases breast cancer risk (3–6). However, several cohort studies, in consistent with such an hypothesis have recently been reported (1,7). In addition, attention has focused on the role of specific fatty acids (FA) as enhancers, (i.e. linoleic acid (LA)(C18:2, n-6) (9–11)) inhibitors, (i.e. eicosapentaenoic acid (EIA)(C20:5, n-3) (12,13)) or neutral effectors, (i.e. oleic acid (OL)(C18:1, n-9) (8,14)) of breast cancer development and metastatic spread. One weakness of the fat hypothesis is that the mechanism(s) by which the type and/or amount of fat may exert their effects on breast cancer are poorly understood (6,15). In this regard, the effects of specific nutrients, including lipids, on gene expression have recently attracted attention (16–19). In light of the controversy surrounding the fat hypothesis, elucidation of the cellular and molecular mechanisms by which dietary fat exerts its biological effects, may provide the means to resolve this important public health issue.


Mammary Tumor Human Breast Cancer Cell Line Dietary Fatty Acid Mammary Tumorigenesis Mismatched Amplification Mutation Assay 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Z. Ronai
    • 1
  • J. Tillotson
    • 1
  • L. Cohen
    • 2
  1. 1.Molecular Carcinogenesis ProgramAmerican Health FoundationValhallaUSA
  2. 2.Section of Nutrition and EndocrinologyAmerican Health FoundationValhallaUSA

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