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Abstracts

  • Andrew Yen
  • Megan Williams
  • Joseph D. Platko
  • Channing Der
  • Mark Hisaka
  • Alexander M. Feigin
  • C. Wang
  • C. D. Stiles
  • T. C. Cavalcanti
  • F. Guimaraesr
  • H. F. Gumerato
  • Q. S. Tahinc
  • Anita V. Ratnan
  • Hex Jby Su
  • Daniel D. Bxrle
  • Marc D. Basson
  • Fu Hong
  • Amalia Bianchi-Santamaria
  • Leonida Santamaria
  • Amalia Bianchi-Santamaria
  • Sergio Fedeli
  • Leonida Santamaria
  • A. Coral
  • P.A. Lamartiniere
  • B. C. Pence
  • M. J. Butler
  • D. M. Dunn
  • M. F. Miller
  • N. S. M. D. Wickramasinghe
  • H. Jo
  • J. M. McDonald
  • R. W. Hardy
  • G. Fernandes
  • B. Chandrasekar
  • J. T. Venkatraman
  • C. N. Kuratko
  • B. C. Pence
  • Mickie Bhatia
  • James B. Kirkland
  • Kelly A. Meckling-Gill
  • Nurul H. Sarkar
  • HuiWu Li
  • Wei Zhao
  • Trevor G. Atkinson
  • Danielle Martin
  • Helen de Salis
  • Kelly A. Meckling-Gill
  • Christine Teixeira
  • Christine Pratt
  • A. A. Kulkarni
  • M. Sajan
  • K. Datta
  • P. Roy
  • A. P. Kulkarni
  • Rayudu Gopalakrishna
  • Zhen-hai Chen
  • Usha Gundimeda
  • S. J. Braunhut
  • D. Medeiros
  • M. R. Freeman
  • M. A. Moses
  • G. Y. Yang
  • A. M. Shamsuddin
  • Ivana Vucenik
  • Guang-Yu Yang
  • Abulkalam M. Shamsuddin
  • E. A. Paisley
  • James Kaput
  • H. J. Mangian
  • W. J. Visek
  • R. J. Hohl
  • K. Lewis
  • King-Thom Chung
  • Wen Chen
  • Yonggui Zhou
  • Peter P. Fu
  • Ronald W. Hart
  • Ming W. Chou
  • Valerian E. Kagan
  • Jack C. Yalowich
  • Julia Y. Tyurina
  • Vladimir A. Tyurin
  • V. B. Ritov
  • R. Goldman
  • D. A. Stoyanovsky
  • E. V. Menshikova
  • V. E. Kagan
  • Gerhard Zugmaier
  • Robert Jäger
  • Marco Gottardis
  • Klaus Havemann
  • Cornelius Knabbe
  • Ruth A. Hagerman
  • Susan M. Fischer
  • Mary F. Locniskar
  • H. S. Black
  • G. Okotie-Eboh
  • J. Gerguis
  • J. I. Urban
  • J. I. Thornby
  • H. MerrillJr.
  • Leonard A. Sauer
  • Robert T. Dauchy
  • Jeanne M. Connolly
  • David P. Rose
  • H. L. Gensler
  • K. Gerrish
  • Y-M. Peng
  • M-J. Xu
  • Laura J. Jenski
  • Mustapha Zerouga
  • Lian Zhang
  • William Stillwell
  • P. Homayoun
  • M. K. Gupta
  • F. Lente
  • U. Tuason
  • T. Budd
  • M. Yazlovitskaya
  • George Melnykovych
  • Jenny A. Matthew
  • Steve Middleton
  • Alison Prior
  • Hugh J. Kennedy
  • Ian W. Fellows
  • Ian T. Johnson
  • Ping-Ping Lee
  • Margot M. Ip
  • C. Gercel-Taylor
  • D. D. Taylor
  • T. P. Pretlow
  • L. Hudson
  • M. A. O’Riordan
  • T. G. Pretlow
  • L. A. Cohen
  • E. Zang
  • A. Rivenson
  • Adria R. Sherman
  • Deborah Hrabinski
  • Vance Berger
  • Craig Dees
  • Don Henley
  • Murray Ardies
  • Curtis Travis
  • Doris M. Benbrook
  • Kevin Brewer
  • Coy Heldermon
  • Evelyn Nunez
  • Przemko Walisewaki
  • C. P. Reynolds
  • P. Einhorn
  • P. Schindler
  • J. J. Zuo
  • A. A. Khan
  • V. I. Avramis
  • J. G. Villablanca
  • D. P. Gaposchkin
  • S. A. Broitman
  • Singer C. Kosacoisky
  • S. A. Broitman
  • M. Shlyankevich
  • R. Lee
  • K. Garden
  • Y.-C. Lee
  • Y.-J. Surh
  • Meena S. Katdare
  • Michael P. Osborne
  • Nitin T. Telang
  • Narayan Shivapurkar
  • Zhaocheng Tang
  • Oliver Alabaster
  • Jerzy A. Jaskeiwicz
  • Yu Zhao
  • Yoshiharu Shimomura
  • David W. Crabb
  • Robert A. Harris
  • Jan Zaleski
  • Patricia A. Richter
  • Gloria Y. Kwei
  • Frederick C. Kauffman
  • L. Hilakivi-Clarke
  • I. Onojafe
  • E. Cho
  • R. Clarke
  • M. E. Lippman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 354)

Abstract

Expression of an activated raf transgene accelerated the terminal myeloid differentiation of HL-60 human promyelocytic leukemia cells induced by retinoic acid. A similar result was obtained when 1,25-dihydroxy vitamin D3 was used to induce monocytic differentiation. The stable transfectants were derived by transfecting HL-60 cells with DNA encoding an N-terminal truncated raf-1 protein. In normal HL-60 cells retinoic acid is known to induce a CSF-1 dependent metabolic cascade culminating in GO arrest and phenotypic conversion. Early in this cascade, expression of the RB tumor suppressor gene product is down regulated. A progressive redistribution of the form of the protein from largely hyper-phosphorylated protein to the hypo-phosphorylated form begins later with GO arrest and differentiation. In the activated raf transfected cells, RB down regulation occurred more rapidly, consistent with accelerated differentiation. But the conversion to the hypo-phosphorylated form was not accelerated and occurred after GO arrest and phenotypic conversion to myeloid differentiated cells. Thus raf activation appears to be a component of the retinoic acid induced metabolic cascade culminating in terminal differentiation. In this cascade raf activation promotes RB down regulation. The data are consistent with a model in which raf is an effector of this CSF-1 dependent metabolic cascade which culminates in terminal cell differentiation, and RB down regulation is one of the downstream consequences of raf action. Furthermore they indicate that RB down regulation may be an essential component of the cellular processes causing GO arrest and differentiation, but RB hypo-phosphorylation is more likely a consequence thereof and not a cause.

Keywords

Retinoic Acid Aberrant Crypt Focus Normal Human Keratinocytes Retinyl Palmitate Perillyl Alcohol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Reference

  1. Fireman Z, Rozen P, Fine N, Chetrit A : Influence of demographic parameters on rectal epithelial proliferation Cancer Letters 1989; 47: 133 - 140Google Scholar
  2. Lipkin M. : Biomarkers of increased susceptibility to gastrointestinal cancer: New application to studies of cancer prevention in human subjects. Cancer Research 1988; 48: 235 - 245.Google Scholar
  3. Matthew JA, Pell JD, Prior A, Kennedy HJ, Fellows IW, Gee JM, Burton J, Johnson IT.: Validation of a simple technique for the detection of abnormal mucosal cell replication in humans. European Journal of Cancer Prevention (in press)Google Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Andrew Yen
    • 1
  • Megan Williams
    • 1
  • Joseph D. Platko
    • 1
  • Channing Der
    • 1
  • Mark Hisaka
    • 1
  • Alexander M. Feigin
    • 2
  • C. Wang
    • 3
  • C. D. Stiles
    • 4
  • T. C. Cavalcanti
    • 5
  • F. Guimaraesr
    • 5
  • H. F. Gumerato
    • 6
  • Q. S. Tahinc
    • 7
  • Anita V. Ratnan
    • 8
  • Hex Jby Su
    • 8
  • Daniel D. Bxrle
    • 8
  • Marc D. Basson
  • Fu Hong
  • Amalia Bianchi-Santamaria
    • 9
  • Leonida Santamaria
    • 9
  • Amalia Bianchi-Santamaria
    • 10
  • Sergio Fedeli
    • 11
  • Leonida Santamaria
    • 10
  • A. Coral
    • 12
  • P.A. Lamartiniere
    • 12
  • B. C. Pence
    • 13
  • M. J. Butler
    • 13
  • D. M. Dunn
    • 13
  • M. F. Miller
    • 13
  • N. S. M. D. Wickramasinghe
    • 14
  • H. Jo
    • 14
  • J. M. McDonald
    • 14
  • R. W. Hardy
    • 14
  • G. Fernandes
    • 15
  • B. Chandrasekar
    • 15
  • J. T. Venkatraman
    • 15
  • C. N. Kuratko
    • 16
  • B. C. Pence
    • 16
  • Mickie Bhatia
    • 17
  • James B. Kirkland
    • 17
  • Kelly A. Meckling-Gill
    • 17
  • Nurul H. Sarkar
    • 18
  • HuiWu Li
    • 18
  • Wei Zhao
    • 18
  • Trevor G. Atkinson
    • 19
  • Danielle Martin
    • 19
  • Helen de Salis
    • 19
  • Kelly A. Meckling-Gill
    • 19
  • Christine Teixeira
    • 20
  • Christine Pratt
    • 20
  • A. A. Kulkarni
    • 21
  • M. Sajan
    • 21
  • K. Datta
    • 21
  • P. Roy
    • 21
  • A. P. Kulkarni
    • 21
  • Rayudu Gopalakrishna
    • 22
  • Zhen-hai Chen
    • 22
  • Usha Gundimeda
    • 22
  • S. J. Braunhut
    • 23
  • D. Medeiros
    • 23
  • M. R. Freeman
    • 23
  • M. A. Moses
    • 23
  • G. Y. Yang
    • 24
  • A. M. Shamsuddin
    • 24
  • Ivana Vucenik
    • 25
  • Guang-Yu Yang
    • 26
  • Abulkalam M. Shamsuddin
    • 26
  • E. A. Paisley
    • 27
  • James Kaput
    • 27
  • H. J. Mangian
    • 27
  • W. J. Visek
    • 27
  • R. J. Hohl
    • 28
  • K. Lewis
    • 28
  • King-Thom Chung
    • 29
  • Wen Chen
    • 30
  • Yonggui Zhou
    • 29
  • Peter P. Fu
    • 30
  • Ronald W. Hart
    • 30
  • Ming W. Chou
    • 30
  • Valerian E. Kagan
    • 31
  • Jack C. Yalowich
    • 31
  • Julia Y. Tyurina
    • 31
  • Vladimir A. Tyurin
    • 31
  • V. B. Ritov
    • 32
  • R. Goldman
    • 32
  • D. A. Stoyanovsky
    • 32
  • E. V. Menshikova
    • 32
  • V. E. Kagan
    • 32
  • Gerhard Zugmaier
    • 33
  • Robert Jäger
    • 33
  • Marco Gottardis
    • 35
  • Klaus Havemann
    • 33
  • Cornelius Knabbe
    • 34
  • Ruth A. Hagerman
    • 36
    • 37
  • Susan M. Fischer
    • 36
    • 37
  • Mary F. Locniskar
    • 36
    • 37
  • H. S. Black
    • 38
  • G. Okotie-Eboh
    • 38
  • J. Gerguis
    • 38
  • J. I. Urban
    • 38
  • J. I. Thornby
    • 38
  • H. MerrillJr.
    • 39
  • Leonard A. Sauer
    • 40
  • Robert T. Dauchy
    • 40
  • Jeanne M. Connolly
    • 41
  • David P. Rose
    • 41
  • H. L. Gensler
    • 42
  • K. Gerrish
    • 42
  • Y-M. Peng
    • 42
  • M-J. Xu
    • 42
  • Laura J. Jenski
    • 43
  • Mustapha Zerouga
    • 43
  • Lian Zhang
    • 43
  • William Stillwell
    • 43
  • P. Homayoun
    • 44
  • M. K. Gupta
    • 44
  • F. Lente
    • 44
  • U. Tuason
    • 44
  • T. Budd
    • 44
  • M. Yazlovitskaya
    • 45
  • George Melnykovych
    • 46
  • Jenny A. Matthew
    • 47
  • Steve Middleton
    • 48
  • Alison Prior
    • 48
  • Hugh J. Kennedy
    • 48
  • Ian W. Fellows
    • 48
  • Ian T. Johnson
    • 47
  • Ping-Ping Lee
    • 49
  • Margot M. Ip
    • 49
  • C. Gercel-Taylor
    • 50
  • D. D. Taylor
    • 50
  • T. P. Pretlow
    • 51
  • L. Hudson
    • 51
  • M. A. O’Riordan
    • 51
  • T. G. Pretlow
    • 51
  • L. A. Cohen
    • 52
  • E. Zang
    • 52
  • A. Rivenson
    • 52
  • Adria R. Sherman
    • 53
  • Deborah Hrabinski
    • 53
  • Vance Berger
    • 54
  • Craig Dees
    • 55
  • Don Henley
    • 55
  • Murray Ardies
    • 56
  • Curtis Travis
    • 55
  • Doris M. Benbrook
    • 57
  • Kevin Brewer
    • 57
  • Coy Heldermon
    • 57
  • Evelyn Nunez
    • 57
  • Przemko Walisewaki
    • 57
  • C. P. Reynolds
    • 58
  • P. Einhorn
    • 58
  • P. Schindler
    • 58
  • J. J. Zuo
    • 58
  • A. A. Khan
    • 58
  • V. I. Avramis
    • 58
  • J. G. Villablanca
    • 58
  • D. P. Gaposchkin
    • 59
  • S. A. Broitman
    • 59
  • Singer C. Kosacoisky
    • 60
  • S. A. Broitman
    • 60
  • M. Shlyankevich
    • 61
  • R. Lee
    • 61
  • K. Garden
    • 61
  • Y.-C. Lee
    • 61
  • Y.-J. Surh
    • 61
  • Meena S. Katdare
    • 62
  • Michael P. Osborne
    • 62
  • Nitin T. Telang
    • 62
  • Narayan Shivapurkar
    • 63
  • Zhaocheng Tang
    • 63
  • Oliver Alabaster
    • 63
  • Jerzy A. Jaskeiwicz
    • 64
    • 65
  • Yu Zhao
    • 64
    • 65
  • Yoshiharu Shimomura
    • 64
    • 65
  • David W. Crabb
    • 64
    • 65
  • Robert A. Harris
    • 64
    • 65
  • Jan Zaleski
    • 66
  • Patricia A. Richter
    • 66
  • Gloria Y. Kwei
    • 67
  • Frederick C. Kauffman
    • 66
  • L. Hilakivi-Clarke
    • 68
  • I. Onojafe
    • 68
  • E. Cho
    • 68
  • R. Clarke
    • 68
  • M. E. Lippman
    • 68
  1. 1.Cancer Biology Laboratory, Department of PathologyCornell UniversityIthacaUSA
  2. 2.Monell Chemical Senses CenterPhiladelphiaUSA
  3. 3.Center of Molecular Biology for Oral DiseasesUniversity of Illinois at ChicagoChicagoUSA
  4. 4.Division of Molecular and Cellular Biology, Dana-Farber Cancer InstituteHarvard Medical SchoolBostonUSA
  5. 5.LaboratOrio de Pesquisas BioquimicasCAISM/UNICAMPCampinasBrasil
  6. 6.Departamento de Ciencia de AlimentosFEA/UNICAMPUSA
  7. 7.Tumor Markers LaboratoryFox Chase Cancer CenterPhiladelphiaUSA
  8. 8.Department of MedicineUniversity of CaliforniaSan FranciscoUSA
  9. 9.“C. Golgi” Institute of General Pathology, Centro TumoriUniversity of PaviaPaviaItaly
  10. 10.Camillo Golgi Institute of General Pathology, Centro TumoriUniversity of PaviaPaviaItaly
  11. 11.Division of Internal MedicineDelmati HospitalMilanoItaly
  12. 12.Department of Pharmacology and ToxicologyUniversity of AlabamaBirminghamUK
  13. 13.Health Sciences CenterTexas Tech UniversityLubbockUSA
  14. 14.Department of PathologyUniversity of Alabama at BirminghamBirminghamUSA
  15. 15.Medicine/Clinical ImmunologyUni. of Texas HSCSan AntonioUSA
  16. 16.Health Sciences Center, Department of PathologyTexas Tech UniversityLubbockUSA
  17. 17.Department of Nutritional SciencesUniversity of GuelphGuelphCanada
  18. 18.Department of Immunology and MicrobiologyMedical College of GeorgiaAugustaUSA
  19. 19.Department of Nutritional SciencesUniversity of GuelphGuelphCanada
  20. 20.Department of PharmacologyUniversity of OttawaOttawaCanada
  21. 21.Florida Toxicological Research Center, College of Public HealthUniversity of South FloridaTampaUSA
  22. 22.Department of Cell and Neurobiology, School of MedicineUniversity of Southern CaliforniaLos AngelesUSA
  23. 23.Departments of OphthalmologyUrology and Surgery at Children’s Hospital and the Harvard Medical SchoolBostonUSA
  24. 24.Department of PathologyUniversity of Maryland School of MedicineBaltimoreUSA
  25. 25.Department of Medical and Research TechnologyUniversity of Maryland School of MedicineBaltimoreUSA
  26. 26.Department of PathologyUniversity of Maryland School of MedicineBaltimoreUSA
  27. 27.University of Illinois College of MedicineUrbanaUSA
  28. 28.University of Iowa College of MedicineIowa CityUSA
  29. 29.Department of BiologyThe University of MemphisMemphisUSA
  30. 30.National Center for Toxicological ResearchJeffersonUSA
  31. 31.Departments of Environmental and Occupational Health and PharmacologyUniversity of Pittsburgh and Pittsburgh Cancer InstitutePittsburghUSA
  32. 32.Department of Environmental and Occupational HealthUniversity of Pittsburgh and Pittsburgh Cancer InstituteUSA
  33. 33.Department of Medical OncologyMarburg University Medical CenterMarburgGermany
  34. 34.Department of Clinical ChemistryHamburg University Medical CenterGermany
  35. 35.Department PharmacologyLigandLa JollaUSA
  36. 36.Division of Nutritional SciencesUniversity of TexasAustinUSA
  37. 37.Science ParkUTSCCSmithvilleUSA
  38. 38.Baylor College of Medicine and Veterans Affairs Medical CenterHoustonUSA
  39. 39.Biochemistry Dept.Emory University School of Medicine, Rollins Research CenterAtlantaUSA
  40. 40.Laboratory for Cancer Research, Medical Research InstituteThe Mary Imogene Bassett HospitalCooperstownUSA
  41. 41.American Health FoundationValhallaUSA
  42. 42.Departments of Radiation Oncology and Internal Medicine, Cancer CenterUniversity of ArizonaTucsonUSA
  43. 43.Department of BiologyIndiana UniversityIndianapolisUSA
  44. 44.The Cleveland Clinic FoundationClevelandUSA
  45. 45.Department of Microbiology, Molecular Genetics and ImmunologyUniversity of Kansas Medical CenterKansas CityUSA
  46. 46.Department of VeteransAffair Medical CenterKansas CityUSA
  47. 47.AFRC Institute of Food ResearchNorwich Research ParkColney, NorwichUK
  48. 48.Norfolk and Norwich HospitalNorwichUK
  49. 49.Roswell Park Cancer InstituteBuffaloUSA
  50. 50.Dept of Obstetrics and GynecologyUniv. of Louisville School of MedicineLouisvilleUSA
  51. 51.Institute of PathologyCase Western Reserve University School of MedicineClevelandUSA
  52. 52.American Health FoundationValhallaUSA
  53. 53.Departments of Nutritional SciencesStatistics RutgersThe State University of New JerseyNJNew BrunswickUSA
  54. 54.Statistics RutgersThe State University of New JerseyNew BrunswickUSA
  55. 55.Health Sciences Research DivisionOak Ridge National LaboratoryOak RidgeUSA
  56. 56.Center for Exercise and Cardiovascular ResearchNortheastern Illinois UniversityChicagoUSA
  57. 57.University of Oklahoma Health Sciences CenterOklahoma CityUSA
  58. 58.Division of Hematology-Oncology, Childrens Hospital Los AngelesUniversity of Southern CaliforniaLos AngelesUSA
  59. 59.Departments of Pathology and MicrobiologyBoston University School of MedicineBostonUSA
  60. 60.Boston University Department of PathologyBoston University School of MedicineBostonUSA
  61. 61.Department of Epidemiology and Public HealthYale University School of MedicineNew HavenUSA
  62. 62.Strang-Cornell Cancer Research LaboratoryCornell University Medical CollegeNew YorkUSA
  63. 63.Institute for Disease PreventionGeorge Washington University Medical CenterWashington D.C.USA
  64. 64.Departments of Biochemistry & Molecular Biology and MedicineIndiana University School of MedicineIndianapolisUSA
  65. 65.Department of BioscienceNagoya University of TechnologyNagoya 466Japan
  66. 66.Lab. for Cell. and Biochem. Toxicol.Rutgers UniversityPiscatawayUSA
  67. 67.Merck Res. Lab.West PointUSA
  68. 68.Lombardi Cancer Research CenterGeorgetown UniversityNWUSA

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