Effects of RFR/EMF Exposure on Pineal/Melatonin

  • Peter Semm
  • T. Schneider
Part of the NATO ASI Series book series (NSSA, volume 274)


It was demonstrated that the pineal organ (Epiphysis cerebri), an endocrine gland located in the epithalamus of vertebrates, is capable of responding to magnetic stimuli. After the discovery that the spontaneous electrical activity of single pinealocytes of birds and mammals could be altered by magnetic stimuli, it was shown that also the nocturnal synthesis of the pineal hormone N- acetyl-5-methoxytryptamine (Melatonin) was inhibited by a change of the ambient magnetic field. Besides the physiological responses to artificial magnetic fields, there are several indications that the orientation behavior of homing pigeons and migrating birds is influenced by the earth’s magnetic field. It is believed that the photoreceptors of the retinae and the avian pineal gland may serve as magnetoreceptors. Moreover it was shown that regular daily and annual variations of the geomagnetic field, caused by solar winds acting on the magnetosphere of the earth’s sunlit side, could possibly play a role on circadian and circannual rhythms. Clinical relevant results coupled with artificial magnetic influences and possible therapeutic magnetic treatment are discussed.


Pineal Gland Pineal Organ Magnetic Compass Melatonin Synthesis Homing Pigeon 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    P. Semm, T. Schneider and L. Vollrath, Nature 288:607–608, (1980).PubMedCrossRefGoogle Scholar
  2. 2.
    L. Maffei, E. Meschini and F. Papi, Z. Tierpsychol., 62:151–156 (1983).CrossRefGoogle Scholar
  3. 3.
    P. Semm, H. Brettschneider, K. Dölla and W. Wiltschko, in: Comparative Physiology of Environmental Adaptations, ed., Pevet, P., 3:171-182 (1987).Google Scholar
  4. 4.
    P. Semm, D. Nohr, C. Demaine and W. Wiltschko, J. Comp. Physiol. 155:283–288 (1984).CrossRefGoogle Scholar
  5. 5.
    P. Semm and C. Demaine, J. Comp. Physiol. 159:619–625 (1986).CrossRefGoogle Scholar
  6. 6.
    R.C. Beason and P. Semm, Neurosci. Lett. 80:229 (1987).PubMedCrossRefGoogle Scholar
  7. 7.
    H.A. Welker, P. Semm, R.P. Willig, J.C. Commente, W. Wiltschko, L. Vollrath, Exp. Brain. Res. 50:426–432 (1983).PubMedGoogle Scholar
  8. 8.
    B.K. Wilson, L.E. Anderson, D.I. Hilton and R.D. Phillips, Bioelectromagnetics 2:371–380 (1981).PubMedCrossRefGoogle Scholar
  9. 9.
    W. Wiltschko in: Animal Migration, Navigation, and Homing, K. Schmidt-Koenig & W.T. Keeton, eds. Springer-Verlag, Berlin, 50–58 (1978).Google Scholar
  10. 10.
    W. Wiltschko and R. Wiltschko, Science 176:62–64 (1972).PubMedCrossRefGoogle Scholar
  11. 11.
    W. Wiltschko and R. Wiltschko, Current Ornithology 5:67–121 (1988).CrossRefGoogle Scholar
  12. 12.
    M.A. Persinger, Experientia 43:92–104 (1987).PubMedCrossRefGoogle Scholar
  13. 13.
    C. Walcott, J. exp. Biol. 70:105–123 (1977).Google Scholar
  14. 14.
    S. Reuss, P. Semm and L. Vollrath, Neurosci. Lett. 40:23–26 (1982).CrossRefGoogle Scholar
  15. 15.
    M. Villa, P. Mustarelli and M. Caprotti, Life Science 69:85–92 (1991).CrossRefGoogle Scholar
  16. 16.
    A. Lerchl, K.O. Nonaka, K.A. Stokkan and R.J. Reiter, Biochem. Biophys. Res. Comm. 169:102–108 (1990).PubMedCrossRefGoogle Scholar
  17. 17.
    A. Lerchl, K.O. Honaka and R.J. Reiter, J. Pineal Res. 10:109–106 (1991a).PubMedCrossRefGoogle Scholar
  18. 18.
    A. Chics-DeMet, E. Chics-DeMet, H. Wu, R. Coopersmith and M. Leon, Neuroscience Abstract 156:17 (1988).Google Scholar
  19. 19.
    M. Zeise and P. Semm, J. Comp. Physiol. 157:23–29 (1985).CrossRefGoogle Scholar
  20. 20.
    M.S. Keshavan, B.N. Gangadhar, R.U. Gautam, V.B. Ajiit and R.L. Kapur, Neurosci. Lett. 22:205–208 (1981).PubMedCrossRefGoogle Scholar
  21. 21.
    T. Deguchi and J. Axelrod, Analyt.Biochem. 50:174–179 (1972).PubMedCrossRefGoogle Scholar
  22. 22.
    P. Semm, T. Schneider, L. Vollrath and W. Wiltschko, in: Avian Navigation, F. Papi and H.G. Wallraff eds., 329–337, Springer Verlag, Berlin-Heidelberg-New York (1982).CrossRefGoogle Scholar
  23. 23.
    C. Demaine and P. Semm, Neurosci.Lett. 62:119–122 (1985).PubMedCrossRefGoogle Scholar
  24. 24.
    P. Semm and L. Vollrath, J. Comp. Physiol. 154:675–681 (1984).CrossRefGoogle Scholar
  25. 25.
    C. Demaine and P. Semm, Neurosci. Lett. 72:158–16226 (1986).PubMedCrossRefGoogle Scholar
  26. 26.
    K. Mai and P. Semm, J. Hirnforschung 31:331–336 (1989).Google Scholar
  27. 27.
    S. Reuss and P. Semm, Naturwissenschaften 74:38–39 (1987).PubMedCrossRefGoogle Scholar
  28. 28.
    G. Cremer-Bartels, K. Krause and H.J. Küchle, Graefe’s Arch.Clin.Exp. Ophthalmol. 220:248–252 (1983).CrossRefGoogle Scholar
  29. 29.
    G. Cremer-Bartels, K. Krause, G. Mitoskas and G. Brodersen, Naturwiss. 71:567–574 (1984).PubMedCrossRefGoogle Scholar
  30. 30.
    J.L. Bardasano, A.J. Meyer and L Picazo, J. Hirnforschung 26:471–475 (1985).Google Scholar
  31. 31.
    S. Reuss, J. Olcese, L. Vollrath, M. Skalej and M. Meves, IRCS Med. Sci. 13:471 (1985).Google Scholar
  32. 32.
    J. Milin, M. Bajic and V. Brakus, Neuroscience 26, 3:1083–1092 (1988).PubMedCrossRefGoogle Scholar
  33. 33.
    S.A. Rivkees, V.M. Cassone, D.R. Weaver and S.M. Reppert, Endocrinol. 125, 1:363–368 (1989).CrossRefGoogle Scholar
  34. 34.
    D.R. Weaver, S.A. Rivkees and S.M. Reppert, J. Neuroscience 9, 7:2581–2590 (1989).Google Scholar
  35. 35.
    L.L. Carlson and S.M. Reppert, Endocrinology 125:160a (1989).CrossRefGoogle Scholar
  36. 36.
    H. Bartsch, L. Bartsch and D. Gupta, in: Neuroendocrinology: New Frontiers. Brain Research Promotion, D. Gupta, H.A. Wollmann, M.B. Ranke, eds., Tübingen, Germany, 333 (1990).Google Scholar
  37. 37.
    F. Anton-Tay, J.L. Diaz, and A. Fernandez-Guardiola, Life Sci. 10:841–850 (1971).CrossRefGoogle Scholar
  38. 38.
    S.H. Kennedy, S. Tighe, G. McVey and G.M. Brown, J. Nerv. Mental Disease 177, 5:300–303 (1989).CrossRefGoogle Scholar
  39. 39.
    F. Tortosa, M. Piug-Domingo, M.A. Peinado, J. Oriola, S.M. Webb and A. de Leiva, Acta Endocrinol. Copenh. 120:574–578 (1989).PubMedGoogle Scholar
  40. 40.
    S.W. Holmes and D. Sugden, Br. J. Pharmacol., 76:95–101 (1982).PubMedCrossRefGoogle Scholar
  41. 41.
    B.D. Goldman, J.M. Darrow and L. Yogev, Endocrinology 114, 6:2074–2083 (1984).PubMedCrossRefGoogle Scholar
  42. 42.
    F. Waldhauser and H. Steger, J. Neural. Transm. 21:183–197 (1986).Google Scholar
  43. 43.
    G.C. Brainard, L.J. Petterborg, B.A. Richardson and R.J. Reiter, Neuroendocrinology 35:342–348 (1982).PubMedCrossRefGoogle Scholar
  44. 44.
    E. Gwinner, J. Comp. Physiol. 126:123–129 (1978).CrossRefGoogle Scholar
  45. 45.
    G.J.M. Maestroni, A. Conti and W. Pierpaoli, J. Neuroimmunol 13:19–30 (1986).PubMedCrossRefGoogle Scholar
  46. 46.
    E.D. Terracini and F.A. Brown, Physiol. Zool. 35:27–37 (1962).Google Scholar
  47. 47.
    V.L. Bliss and F.H. Heppner, Nature 261:411–412 (1976).PubMedCrossRefGoogle Scholar
  48. 48.
    J.A. Brown Jr. and K.M. Scow, J. inierdiscipl. Cycle Res. 9:137–145 (1978).CrossRefGoogle Scholar
  49. 49.
    K. Rudolph, A. Wirz-Justice, K. Kräuchi and H. Feer, Brain Research 446:159–160 (1988).PubMedCrossRefGoogle Scholar
  50. 50.
    P.A. Anninos, N. Tsagas, R. Sandyk and K. Derpapas, Intern. J. Neuroscience 60:141–171 (1991).Google Scholar
  51. 51.
    R. LaPorte, L. Kus, R.A. Wisniewski, M.M. Prechel, B. Azar-Kia and J.A. McNulty, Brain Res. 506:294–296 (1990).PubMedCrossRefGoogle Scholar
  52. 52.
    A. Lerchl, R.J. Reiter, K.A. Howes, K.O. Nonake and K.A. Stokkan, Neurosci. Lett. 124:213–215 (1991).PubMedCrossRefGoogle Scholar
  53. 53.
    J.B. Phillips, Society for Neuroscience: Abstracts 13:397 (1987).Google Scholar
  54. 54.
    M.J.M. Leask, Nature 267:144–145 (1977).PubMedCrossRefGoogle Scholar
  55. 55.
    K. Schulten and A. Windemuth, in: Biophysical Effects of Steady Magnetic Fields. G. Maret, J. Kiepenheuer, & N. Boccara, eds. Springer-Verlag, Berlin. 167–172 (1986).Google Scholar
  56. 56.
    R.C. Beason and P. Semm, in: Orientation in Birds, P. Berthold, ed., Birkhäuser Verlag Basel/Switzerland, 106–127 (1991).CrossRefGoogle Scholar
  57. 57.
    A.J. Kalmijn, J. Exp. Biol. 55:371–383 (1971).PubMedGoogle Scholar
  58. 58.
    A.J. Kalmijn, Science 218:916–918 (1982).PubMedCrossRefGoogle Scholar
  59. 59.
    T. Leucht., Naturwissenschaften 74:441–443 (1987).PubMedCrossRefGoogle Scholar
  60. 60.
    K.P. Ossenkopp, M. Kavaliers and M. Hirst, Neurosci. Lett. 40:321–325 (1983).PubMedCrossRefGoogle Scholar
  61. 61.
    M. Lindauer and H. Martin, Z. Vergl. Physiol., 60:219–243 (1968).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Peter Semm
    • 1
  • T. Schneider
    • 1
  1. 1.Zool. Institut, AG MagnetoneurobiologieUniversität FrankfortFrankfort 11Germany

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