Cancer Chemoprevention by Green Tea Components

  • Hasan Mukhtar
  • Santosh K. Katiyar
  • Rajesh Agarwal
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 375)


Since the treatment of cancer is often ineffective once the tumor is diagnosed, considerable efforts have been made in recent years to develop chemopreventive agents, i.e., agents that would prevent cancers from developing in the first place.1 Cancer chemoprevention therefore has become an important emerging area of research that, in addition to providing a practical approach to identifying potentially useful inhibitors of cancer development, also affords opportunities to study the mechanisms of carcinogenesis.2,3 It is appreciated that extrinsic factors such as environmental pollutants and lifestyle play major roles in the development of some forms of human malignancies.4 It is also becoming clear that diet can influence the risk of developing cancer.4 Our food contains not only mutagens and carcinogens, but also a variety of chemicals that are antimutagenic in bacterial test systems and that block carcinogenesis in animal tumor bioassay systems.4 For these reasons, changes in dietary habits with the routine intake of more cancer chemopreventive agents, specifically those which have shown preventive effects in a wide range of animal tumor bioassay systems, are an attractive approach for cancer prevention. Experimental studies in animal tumor models have shown that cancer can be prevented by administration of a variety of chemical compounds, some of which are naturally occurring whereas others are synthetic.2


Mouse Skin Oral Feeding Skin Tumor Hairless Mouse Quinone Reductase 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Hasan Mukhtar
    • 1
  • Santosh K. Katiyar
    • 1
  • Rajesh Agarwal
    • 1
  1. 1.Department of Dermatology, University Hospitals of ClevelandCase Western Reserve UniversityClevelandUSA

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