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Cancer Chemoprevention by Green Tea Components

  • Hasan Mukhtar
  • Santosh K. Katiyar
  • Rajesh Agarwal
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 375)

Abstract

Since the treatment of cancer is often ineffective once the tumor is diagnosed, considerable efforts have been made in recent years to develop chemopreventive agents, i.e., agents that would prevent cancers from developing in the first place.1 Cancer chemoprevention therefore has become an important emerging area of research that, in addition to providing a practical approach to identifying potentially useful inhibitors of cancer development, also affords opportunities to study the mechanisms of carcinogenesis.2,3 It is appreciated that extrinsic factors such as environmental pollutants and lifestyle play major roles in the development of some forms of human malignancies.4 It is also becoming clear that diet can influence the risk of developing cancer.4 Our food contains not only mutagens and carcinogens, but also a variety of chemicals that are antimutagenic in bacterial test systems and that block carcinogenesis in animal tumor bioassay systems.4 For these reasons, changes in dietary habits with the routine intake of more cancer chemopreventive agents, specifically those which have shown preventive effects in a wide range of animal tumor bioassay systems, are an attractive approach for cancer prevention. Experimental studies in animal tumor models have shown that cancer can be prevented by administration of a variety of chemical compounds, some of which are naturally occurring whereas others are synthetic.2

Keywords

Mouse Skin Oral Feeding Skin Tumor Hairless Mouse Quinone Reductase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Anonymous, Effects to prevent cancer are on the increase, Science 253:613 (1991).Google Scholar
  2. 2.
    L.W. Wattenberg, Inhibition of carcinogenesis by naturally occurring and synthetic compounds, in: Antimutagenesis and Anticarcinogenesis, Mechanisms II, Y. Kuroda, D.M. Shankel, M.D. Waters, eds., Plenum Publishing Corp., New York, pp. 155–166 (1990).CrossRefGoogle Scholar
  3. 3.
    LB. Weinstein, Cancer prevention: Recent progress and future opportunities, Cancer Res 51(Suppl):5080s(1991).Google Scholar
  4. 4.
    H.J. Prochaska, A.B. Santamaria, P. Talalay, Rapid detection of inducers of enzymes that protect against carcinogens, Proc Natl Acad Sci USA 89:2394 (1992).PubMedCrossRefGoogle Scholar
  5. 5.
    Z.Y. Wang, SJ. Cheng, Z.C. Zhou, M. Athar, W.A. Khan, D.R. Bickers, H. Mukhtar, Antimutagenic activity of green tea polyphenols, Mutat Res 223:273 (1989).PubMedCrossRefGoogle Scholar
  6. 6.
    A.K. Jain, K. Shimoi, Y. Nakamura, T. Kada, Y. Hara, I. Tomita, Crude tea extracts decrease the mutagenic activity of N-methyl-N′-nitro-N-nitrosoguanidine in vitro and in intragastric tract of rats, Mutat Res 210:1 (1989).PubMedCrossRefGoogle Scholar
  7. 7.
    R.J. Ruch, S.-J. Cheng, J.E. Klaunig, Prevention of cytotoxicity and inhibition of intercellular communication by antioxidant catechins isolated from Chinese green tea, Carcinogenesis 10:1003 (1989).PubMedCrossRefGoogle Scholar
  8. 8.
    Z.Y. Wang, W.A. Khan, D.R. Bickers, H. Mukhtar, Protection against polycyclic aromatic hydrocarbon-induced skin tumor initiation in mice by green tea polyphenols, Carcinogenesis 10:411 (1989).PubMedCrossRefGoogle Scholar
  9. 9.
    W.A. Khan, Z.Y. Wang, M. Athar, D.R. Bickers, H. Mukhtar, Inhibition of the skin tumorigenicity of (+)-7β,8α-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene by tannic acid, green tea polyphenols and quercetin in SENCAR mice, Cancer Lett 42:7 (1988).PubMedCrossRefGoogle Scholar
  10. 10.
    S.K. Katiyar, R. Agarwal, Z.Y. Wang, A.K. Bhatia, H. Mukhtar, (−)-Epigallocatechin-3-gallate in Camellia sinensis leaves from Himalayan region of Sikkim: Inhibitory effects against biochemical events and tumor initiation in SENCAR mouse skin, Nutr Cancer 18:73 (1992).PubMedCrossRefGoogle Scholar
  11. 11.
    S.K. Katiyar, R. Agarwal, G.S. Wood, H. Mukhtar, Inhibition of 12-O-tetradecanoylphorbol-13-acetate-caused tumor promotion in 7,12-dimethylbenz[a]anthracene-initiated SENCAR mouse skin by a polyphenolic fraction isolated from green tea, Cancer Res 52:6890 (1992).PubMedGoogle Scholar
  12. 12.
    M.-T. Huang, C.-T. Ho, Z.Y. Wang, T. Ferraro, T. Finnegan-Olive, Y.-R. Lou, J.M. Mitchell, J.D. Laskin, H. Newmark, C.S. Yang, A.H. Conney, Inhibitory effect of topical application of a green tea polyphenol fraction on tumor initiation and promotion in mouse skin, Carcinogenesis 13:947 (1992).PubMedCrossRefGoogle Scholar
  13. 13.
    Z.Y. Wang, M.-T. Huang, T. Ferraro, C.-Q. Wong, Y.-R. Lou, M. Iatropoulos, C.S. Yang, A.H. Conney, Inhibitory effect of green tea in the drinking water on tumorigenesis by ultraviolet light and 12-O-tetradecanoylphorbol-13-acetate in the skin of SKH-1 mice, Cancer Res 52:1162 (1992).PubMedGoogle Scholar
  14. 14.
    S. Yoshizawa, T. Horiuchi, H. Fujiki, T. Yoshida, T. Okuda, T. Sugimura, Antitumor promoting activity of (−)-epigallocatechin gallate, the main constituent of “tannin” in green tea, Phytotherapy Res 1:44 (1987).CrossRefGoogle Scholar
  15. 15.
    Z.Y. Wang, R. Agarwal, D.R. Bickers, H. Mukhtar, Protection against ultraviolet B radiation-induced photocarcinogenesis in hairless mice by green tea polyphenols, Carcinogenesis 12:1527 (1991).PubMedCrossRefGoogle Scholar
  16. 16.
    Z.Y. Wang, R. Agarwal, W.A. Khan, H. Mukhtar, Protection against benzo(a)pyrene and N-nitrosodiethylamine-induced lung and forestomach tumorigenesis in A/J mice by water extracts of green tea and licorice, Carcinogenesis 13:1491 (1992).PubMedCrossRefGoogle Scholar
  17. 17.
    Z.Y. Wang, J.Y. Hong, M.-T. Huang, K.R. Reuhl, A.H. Conney, C.S. Yang, Inhibition of N-nitrosodiethylamine-and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced tumorigenesis in A/J mice by green tea and black tea, Cancer Res 52:1943 (1992).PubMedGoogle Scholar
  18. 18.
    Y. Xu, C.-T. Ho. S.G. Amin, C. Han, F.L. Chung, Inhibition of tobacco-specific nitrosamine-induced lung tumorigenesis in A/J mice by green tea and its major polyphenol as antioxidants, Cancer Res 52:3875 (1992).PubMedGoogle Scholar
  19. 19.
    Y. Fujita, T. Yamane, M. Tanaka, K. Kuwata, J. Okuzumi, T. Takahashi, H. Fujiki, T. Okuda, Inhibitory effect of (−)-epigallocatechin gallate on carcinogenesis with N-ethyl-N′-nitro-N-nitrosoguanidine in mouse duodenum, Jpn J Cancer Res (Gann) 80:503 (1989).CrossRefGoogle Scholar
  20. 20.
    J. Chen, The effects of Chinese tea on the occurrence of esophageal tumors induced by N-nitrosomethylbenzylamine in rats, Prev Med 21:385 (1992).PubMedCrossRefGoogle Scholar
  21. 21.
    T. Yamane, N. Hagiwara, M. Tateishi, S. Akachi, M. Kim, J. Okuzumi, Y. Kitao, M. Inagake, K. Kuwata, T. Takahashi, Inhibition of azoxymethane-induced colon carcinogenesis in rat by green tea polyphenol fraction, Jpn J Cancer Res (Gann) 82:1336 (1991).CrossRefGoogle Scholar
  22. 22.
    R. Agarwal, H. Mukhtar, Cutaneous chemical carcinogenesis, in: Pharmacology of the Skin, H. Mukhtar, ed., CRC Press, Boca Raton, FL, pp. 371–387 (1991).Google Scholar
  23. 23.
    A.H. Conney, Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: GHA Clowes Memorial Lecture, Cancer Res 42:4875 (1982).PubMedGoogle Scholar
  24. 24.
    H. Mukhtar, R. Agarwal, D.R. Bickers, Cutaneous metabolism of xenobiotics and steroid hormones, in: Pharmacology of the Skin, H. Mukhtar, ed., CRC press, Boca Raton, FL, pp. 89–110 (1991).Google Scholar
  25. 25.
    Z.Y. Wang, M. Das, D.R. Bickers, H. Mukhtar, Interaction of epicatechins derived from green tea with rat hepatic cytochrome P-450, Drug Metab Dispos 16:98 (1988).PubMedGoogle Scholar
  26. 26.
    J. DiGiovanni, Modification of multistage skin carcinogenesis in mice, in: Modification of Tumor Development in Rodents, N. Ito, H. Sugano, eds., Prog Exp Tumor Res, Basel, Karger, vol. 33 pp. 192–199 (1991).Google Scholar
  27. 27.
    R. Agarwal, H. Mukhtar, Oxidative stress in skin chemical carcinogenesis, in: Oxidative Stress in Dermatology, L. Packer, J. Fuchs, eds., Marcel Dekker, NY, pp. 207–242 (1993).Google Scholar
  28. 28.
    J.-P. Perchellet, E.M. Perchellet, Antioxidants and multistage carcinogenesis in mouse skin, Free Radical Biol Med 7:377 (1989).CrossRefGoogle Scholar
  29. 29.
    H.U. Gali, E.M. Perchellet, J.P. Perchellet, Inhibition of tumor promoter-induced ornithine decarboxylase activity by tannic acid and other polyphenols in mouse epidermis in vivo, Cancer Res 51:2820 (1991).PubMedGoogle Scholar
  30. 30.
    R. Agarwal, S.K. Katiyar, S.I.A. Zaidi, H. Mukhtar, Inhibition of tumor promoter-caused induction of ornithine decarboxylase activity in SENCAR mice by polyphenolic fraction isolated from green tea and its individual epicatechin derivatives, Cancer Res 52:3582 (1992).PubMedGoogle Scholar
  31. 31.
    Y. Sun, Free radicals, antioxidant enzymes, and carcinogenesis, Free Radical Biol Med 8:583 (1990).CrossRefGoogle Scholar
  32. 32.
    E.M. Perchellet, E.C. Maata, N.L. Abney, J.-P. Perchellet, Effects of diverse intracellular thiol delivery agents on gluthathione peroxidase activity, the ratio of reduced/oxidized glutathione, and ornithine decarboxylase induction in isolated mouse epidermal cells treated with 12-O-tetradecanoylphorbol-13-acetate, J Cell Phys 131:64 (1987).CrossRefGoogle Scholar
  33. 33.
    J.-P. Perchellet, N.L. Abney, R.M. Thomas, Y.L. Guislain, E.M. Perchellet, Effects of combined treatments with selenium, glutathione and vitamin E on glutathione peroxidase activity, ornithine decarboxylase induction and complete and multistage carcinogenesis in mouse skin, Cancer Res 47:477 (1987).PubMedGoogle Scholar
  34. 34.
    J.-P. Perchellet, N.L. Abney, R.M. Thomas, E.M. Perchellet, E.A. Maatta, Inhibition of multistage tumor promotion in mouse skin by diethyldithiocarbamate, Cancer Res 47:6302 (1987).PubMedGoogle Scholar
  35. 35.
    V. Solanki, R.S. Rana, T.J. Slaga, Diminution of mouse epidermal Superoxide dismutase and catalase activities by tumor promoters, Carcinogenesis 2:1141 (1981).PubMedCrossRefGoogle Scholar
  36. 36.
    T.W. Kensler, D.M. Bush, WJ. Kozumbo, Inhibition of tumor promotion by a biomimetic Superoxide dismutase, Science 221:75 (1983).PubMedCrossRefGoogle Scholar
  37. 37.
    A.D. Jassim, V.L. Sparnins, L.W. Wattenberg, Long term effects of benzo(a)pyrene on the activity of NAD(P)H:quinone reductase in the forestomach and glandular stomach of ICR/Ha mice, Cancer Res 50:2064 (1990).PubMedGoogle Scholar
  38. 38.
    H. Wefers, H. Sies, Hepatic low level chemiluminescence during redox cycling of menadi-one and the menadione-glutathione conjugate: Relation to glutathione and NAD(P)H: quinone reductase (DT-diaphorase) activity, Arch Biochem Biophys 224:568 (1983).PubMedCrossRefGoogle Scholar
  39. 39.
    S.G. Khan, S.K. Katiyar, R. Agarwal, H. Mukhtar, Enhancement of antioxidant and phase II enzymes by oral feeding of green tea polyphenols in drinking water to SKH-1 hairless mice: Possible role in cancer chemoprevention, Cancer Res 52:4050 (1992).PubMedGoogle Scholar
  40. 40.
    S. Kono, M. Ikeda, S. Tokudome, M. Kuratsune, A case-control study of gastric cancer and diet in Northern Kyushu, Jpn J Cancer Res 79:1067 (1988).PubMedCrossRefGoogle Scholar
  41. 41.
    I. Oguni, K. Nasu, S. Yammamoto, T. Nomura, On the antitumor activity of fresh green tea leaf, Agric Biol Chem 52:1879 (1988).CrossRefGoogle Scholar
  42. 42.
    International Agency for Research on Cancer Working Group, Monographs on the evaluation of the carcinogenic risk to humans: Coffee, tea, mate, methylxanthines and methyl-glyoxal, IARC, Vol. 51 (1991).Google Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Hasan Mukhtar
    • 1
  • Santosh K. Katiyar
    • 1
  • Rajesh Agarwal
    • 1
  1. 1.Department of Dermatology, University Hospitals of ClevelandCase Western Reserve UniversityClevelandUSA

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