Inhibition of Tumorigenesis by Chemicals from Garlic and Tea

  • Chung S. Yang
  • Zhi-Yuan Wang
  • Jun-Yan Hong
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 375)


Garlic (Allium sativum) has been used widely in culinary practice and folk remedies in many cultures. Its biological functions are beginning to be understood by studies with modern research tools. Epidemiological studies in China and Italy indicate that more frequent consumption of garlic and other allium vegetables was associated with a lower incidence of gastric cancer.1,2 The inhibition of carcinogenesis by garlic constituents has also been demonstrated in animal models. In previous studies, we demonstrated the selective inhibition and induction of cytochrome P450 enzymes by a garlic compound, diallyl sulfide (DAS), as a possible mechanism for inhibitory action against carcinogenesis.3 In the present paper, this mechanism is discussed further along with new results on the inhibition of tumorigenesis as predicted from metabolism studies.


Tumor Multiplicity Diallyl Disulfide Diallyl Trisulfide Diallyl Sulfide Allium Vegetable 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



diallyl sulfide


diallyl sulfone












(−)epicatechin gallate








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  1. 1.
    W.-C. You, WJ. Blot, Y.-S. Chang, A. Ershow, Z.T. Yang, Q. An, B.E. Henderson, J.F. Fraumeni, Jr., T.G. Wang, Allium vegetables and reduced risk of stomach cancer, J Nail Canc Inst 81:162–164 (1989).CrossRefGoogle Scholar
  2. 2.
    E. Buiatti, D. Palli, A. Decarli, D. Amadori, C. Avellini, S. Bianchi, R. Biserni, F. Cipriani, P. Cocco, A. Giacosa, E. Marubini, R. Puntoni, C. Vindigni, JJ. Fraumeni, W. Blot, A case-control study of gastric cancer and diet in Italy, Int J Canc 44:611–616 (1989).CrossRefGoogle Scholar
  3. 3.
    J.F. Brady, M.-H. Wang, J.-Y. Hong, F. Xiao, Y. Li, J.-S.H. Yoo, S.M. Ning, J.M. Fukuto, J.M. Gapac, C.S. Yang, Modulation of rat hepatic microsomal monooxygenase activities and cytotoxicity by diallyl sulfide, Toxicol Appl Pharmacol 108:342–354 (1991).PubMedCrossRefGoogle Scholar
  4. 4.
    C.S. Yang, J.-S.H. Yoo, H. Ishizaki, J.-Y. Hong, Cytochrome P450IIE1: Roles in nitrosamine metabolism and mechanisms of regulation, Drug Metab Rev 22:147–160 (1990).PubMedCrossRefGoogle Scholar
  5. 5.
    C.S. Yang, J.F. Brady, J.-Y. Hong, Dietary effects on cytochromes P-450, xenobiotics metabolism, and toxicity, FASEB J 6:737–744 (1992).PubMedGoogle Scholar
  6. 6.
    M.A. Hayes, T.H. Rushmore, M.T. Goldberg, Inhibition of hepatocarcinogenic responses to 1,2-dimethylhydrazine by diallyl sulfide, a component of garlic oil, Carcinogenesis 8:1155–1157 (1987).PubMedCrossRefGoogle Scholar
  7. 7.
    MJ. Wargovich, Diallyl sulfide, a flavor component of garlic (Allium sativum), inhibits dimethylhydrazine-induced colon cancer, Carcinogenesis 8:487–489 (1987).PubMedCrossRefGoogle Scholar
  8. 8.
    O.S. Sohn, H. Ishizaki, C.S. Yang, E.S. Fiala, Metabolism of azoxymethane, methylazoxymethanol and N-nitrosodimethylamine by cytochrome P-450IIE1, Carcinogenesis 12:127–131 (1991).PubMedCrossRefGoogle Scholar
  9. 9.
    L.M. Anderson, Increased numbers of iV-nitrosodimethylamine-initiated lung tumors in mice by chronic co-administration of ethanol, Carcinogenesis 9:1717–1719 (1988).PubMedCrossRefGoogle Scholar
  10. 10.
    L. Griciute, M. Castegnaro, J.-C. Bereziat, Influence of ethyl alcohol on carcinogenesis with N-nitrosodimethylamine, Canc Lett 13:345–352 (1981).CrossRefGoogle Scholar
  11. 11.
    S.S. Hecht, D. Hoffman, Tobacco-specific nitrosamines, an important group of carcinogens in tobacco and tobacco smoke, Carcinogenesis 9:875–884 (1988).PubMedCrossRefGoogle Scholar
  12. 12.
    J.-Y. Hong, T. Smith, M.-J. Lee, W. Li, B.-L. Ma, S.-M. Ning, J.F. Brady, P.E. Thomas, C.S. Yang, Metabolism of carcinogenic nitrosamines by rat nasal mucosa and the effect of diallyl sulfide, Canc Res 51:1509–1514 (1991).Google Scholar
  13. 13.
    J.-Y. Hong, Z.-Y. Wang, T. Smith, S. Zhou, S. Shi, C.S. Yang, Inhibitory effects of diallyl sulfide on metabolism and tumorigenicity of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A/J mouse lung, Carcinogenesis 13:901–904 (1992).PubMedCrossRefGoogle Scholar
  14. 14.
    L.W. Wattenberg, V.L. Sparnins, G. Barany, Inhibition of N-nitrosodiethylamine carcinogenesis in mice by naturally occurring organosulfur compounds and monoterpenes, Cane Res 49:2689–2692 (1989).Google Scholar
  15. 15.
    V.L. Sparnins, G. Barany, and L.W. Wattenberg, Effects of organosulfur compounds from garlic and onions on benzo[a]pyrene-induced neoplasia and glutathiohe S-transferase activity in the mouse, Carcinogenesis 9:131–134 (1988).PubMedCrossRefGoogle Scholar
  16. 16.
    M.J. Wargovich, C. Woods, V.W.S. Eng, L.C. Stephens, K. Gray, Chemoprevention of N-nitrosomethylbenzylamine-induced esophageal cancer in rats by the naturally occurring thioether, diallyl sulfide, Cane Res 48:6872–6875 (1988).Google Scholar
  17. 17.
    S. Belman, Onion and garlic oils inhibit tumor promotion, Carcinogenesis 4:1063–1065 (1983).PubMedCrossRefGoogle Scholar
  18. 18.
    Z.Y. Wang, J.-Y. Hong, M.-T. Huang, K. Reuhl, A.H. Conney, C.S. Yang, Inhibition of N-nitrosodiethylamine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced tumorigenesis in A/J mice by green tea and black tea, Cane Res 52:1943–1947 (1992).Google Scholar
  19. 19.
    C. Han, Y. Xu, The effect of Chinese tea on occurrence of esophageal tumor induced by N-nitrosomethylbenzylamine in rats, Biomed Environ Sci 3:35–42 (1990).PubMedGoogle Scholar
  20. 20.
    Y. Xu, C. Han, The effect of Chinese tea on the occurrence of esophageal tumors induced by iV-nitrosomethylbenzylamine formed in vivo, Biomed Environ Sci 3:406–412 (1990).Google Scholar
  21. 21.
    Z.Y. Wang, D.R. Bickers, H. Mukhtar, Interaction of epicatechins derived from green tea with rat hepatic cytochrome P-450, Drug Metab Dispos 16:93–103 (1988).Google Scholar
  22. 22.
    V.L. Sparnins, P.L. Venegas, L.W. Wattenberg, Glutathione 5-transferase activity: Enhancement by compounds inhibiting chemical carcinogenesis and by dietary constituents, J Natl Cane Inst 68:493–496 (1982).Google Scholar
  23. 23.
    S.G. Khan, S.K. Katiyar, R. Agarwal, H. Mukhtar, Enhancement of antioxidant and phase II enzymes by oral feeding of green tea polyphenols in drinking water to SKH-1 hairless mice: Possible role in cancer chemoprevention, Canc Res 52:4050–4052 (1992).Google Scholar
  24. 24.
    Z.Y. Wang, S.J. Cheng, Z.C. Zhou, M. Athar, W.A. Khan, D.R. Bickers, H. Mukhtar, Antimutagenicity of green tea polyphenols, Mutat Res 223:273–285 (1989).PubMedCrossRefGoogle Scholar
  25. 25.
    L. Liu, A. Castonguay, Inhibition of the metabolism and genotoxicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in rat hepatocytes by (+)-catechin, Carcinogenesis 12:1203–1208 (1991).PubMedCrossRefGoogle Scholar
  26. 26.
    R. Bhimani, K. Frankel, Suppression of H2O2 production and oxidative DNA damage in HeLa cells by (−)-epigallocatechin gallate (EGCG), Proc Amer Assoc Cane Res 32:126 (1991).Google Scholar
  27. 27.
    Y. Xu, C.-T. Ho, S.G. Amin, C. Han, F.-L. Chung, Inhibition of tobacco-specific nitrosamine-induced lung tumorigenesis in A/J mice by green tea and its major polyphenol as antioxidants, Cane Res 52:3875–3879 (1992).Google Scholar
  28. 28.
    T.J. Smith, Z.-Y. Guo, P.E. Thomas, F.-L. Chung, M.A. Morse, K. Eklind, C.S. Yang, Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mouse lung microsomes and its inhibition by isothiocyanates, Canc Res 50:6817–6822 (1990).Google Scholar
  29. 29.
    T.J. Smith, Z. Guo, F.J. Gonzalez, F.P. Guengerich, G.D. Stoner, C.S. Yang, Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human lung and liver microsomes and cytochromes P450 expressed hepatoma cell, Canc Res 52:1757–1763 (1992).Google Scholar
  30. 30.
    World Health Organization International Agency for Research on Cancer, Coffee, tea, mate, methylxanthines and methylglyoxal, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans 51:207–271 (1991).Google Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Chung S. Yang
    • 1
  • Zhi-Yuan Wang
    • 1
  • Jun-Yan Hong
    • 1
  1. 1.Laboratory for Cancer Research, College of PharmacyRutgers UniversityPiscatawayUSA

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