Chemical and Mutagenic Specificities of Polycyclic Aromatic Hydrocarbon Carcinogens
Polycyclic aromatic hydrocarbons are found in some broiled meats, as a product of the cooking process,1 and also in vegetables as a contaminant, thus having a widespread distribution through the environment.2 The hydrocarbons are generated through the process of combustion and it seems unlikely, therefore, that exposure to them will ever be completely eliminated. For this reason, a number of researchers, including ourselves, have focused attention on the mechanism of action of these carcinogens with the idea that an understanding of the details of the process of carcinogenesis might facilitate the development of strategies for intervention, such as chemoprevention.
KeywordsPolycyclic Aromatic Hydrocarbon Shuttle Vector Reactive Metabolite Mutagenic Selectivity Genotoxic Carcinogen
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