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Chemical and Mutagenic Specificities of Polycyclic Aromatic Hydrocarbon Carcinogens

  • Anthony Dipple
  • Kimmo Peltonen
  • S. Chau Cheng
  • Helen Ross
  • C. Anita H. Bigger
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 375)

Abstract

Polycyclic aromatic hydrocarbons are found in some broiled meats, as a product of the cooking process,1 and also in vegetables as a contaminant, thus having a widespread distribution through the environment.2 The hydrocarbons are generated through the process of combustion and it seems unlikely, therefore, that exposure to them will ever be completely eliminated. For this reason, a number of researchers, including ourselves, have focused attention on the mechanism of action of these carcinogens with the idea that an understanding of the details of the process of carcinogenesis might facilitate the development of strategies for intervention, such as chemoprevention.

Keywords

Polycyclic Aromatic Hydrocarbon Shuttle Vector Reactive Metabolite Mutagenic Selectivity Genotoxic Carcinogen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Anthony Dipple
    • 1
  • Kimmo Peltonen
    • 2
  • S. Chau Cheng
    • 3
  • Helen Ross
    • 1
  • C. Anita H. Bigger
    • 4
  1. 1.Chemistry of Carcinogenesis Laboratory, ABL-Basic Research ProgramNCI-Frederick Cancer Research and Development CenterFrederickUSA
  2. 2.Department of Industrial Hygiene and ToxicologyInstitute of Occupational HealthHelsinkiFinland
  3. 3.Clinical Research AssociatesNew YorkUSA
  4. 4.Microbiological AssociatesRockvilleUSA

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