Carbohydrate Tumor Marker: Basis for a Simple Test for Colorectal Cancer

  • Abulkalam M. Shamsuddin
  • Kosaku Sakamoto
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 375)


Large intestinal cancer (LIC) is one of the commonest cancers in the industrialized world. It is ranked among the major causes of cancer death in the United States and other Western countries.1 Because of the magnitude of the health problem and associated cost in life and materials, control of this cancer is vital. Prevention is one of the methods of cancer control, and detection of the cancer at the very early stage of the disease is fundamental to prevention. Early detection in its turn is dependent on screening the population (or those at risk) for the disease. Without screening, a 50-year-old person at average risk has approximately a 530 in 10,000 chance of developing invasive colorectal cancer during the rest of her/his life.2 A host of currently available diagnostic assays have been recommended and are in use for LIC screening.3 The common ones are the fecal occult blood tests (FOBT), barium enema X-rays, and endoscopic visualization.3 The cost-effectiveness of these vary tremendously; their use as screening assays is therefore seriously in question.2–7 On one hand, FOBTs are relatively inexpensive2,3 (approximately $10) but are not cost-effective due to their inaccuracies. While the cost of barium enemas and colonoscopies can range from $250–800, they are highly accurate, although marred by the discomfort they cause.


Sialic Acid Fecal Occult Blood Test Precancerous Lesion Alcian Blue Basic Fuchsin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Abulkalam M. Shamsuddin
    • 1
  • Kosaku Sakamoto
    • 2
  1. 1.Department of PathologyUniversity of Maryland School of MedicineBaltimoreUSA
  2. 2.First Department of SurgeryGunma University School of MedicineMaebashi, Gunma 371Japan

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