Chemopreventative Activity of Chlorophyllin: Inhibition of Mutagenicity and Covalent DNA Binding of Benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide

  • Y. J. Surh
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 375)


A variety of plant and vegetable constituents have been found to possess substantial inhibitory effects against some chemical carcinogens and mutagens. One of the major antimutagenic factors in plant and vegetable extracts is chlorophyll. Because of the insolubility of chlorophyll, its water soluble sodium/copper salt, chlorophyllin (CHL), has been used as an alternative in studying the biological effects of chlorophyll. CHL strongly inhibits the genotoxicity of certain environmental mutagens. However, mechanisms by which CHL exerts its antimutagenic effects remain unclear.


Protective Property Mutagenic Activity Parallel Experiment Test Strain Covalent Binding 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Y. J. Surh
    • 1
  1. 1.Department of Epidemiology and Public HealthYale University School of MedicineNew HavenUSA

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