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Chemoprevention of DMBA-Induced Mammary Carcinoma by Inositol Compounds

  • I. Vucenik
  • M. Bansal
  • A. M. Shamsuddin
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 375)

Abstract

Inositol (Ins) and inositol hexaphosphate (InsP6 or phytic acid), are components of cereals. InsP6 is particularly abundant in rice, and wheat bran. Both InsP6 and Ins have been shown to inhibit experimentally induced colon cancers, in both rats and mice; Ins potentiating the action of InsP6. The effect of InsP6 and Ins on 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary carcinoma has been examined in female Sprague-Dawley rats. The rats were started on a treatment regimen of either Na-InsP6, Ins or Na-InSP66+Ins (15 mM each) in drinking water one week prior to intragastric administration of a single dose of 20 mg DMBA. After 17 weeks of treatment our results were as follows

Keywords

Drinking Water Phytic Acid Wheat Bran Body Weight Gain Mammary Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • I. Vucenik
    • 1
    • 2
  • M. Bansal
    • 1
    • 2
  • A. M. Shamsuddin
    • 2
  1. 1.Department of Medical and Research TechnologyUniversity of Maryland School of MedicineBaltimoreUSA
  2. 2.Department of PathologyUniversity of Maryland School of MedicineBaltimoreUSA

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