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Estimated Breast Cancer Risk Reduction with Weight Loss: Implications in Dietetic Practice

  • N. B. Kumar
  • D. V. Schapira
  • G. H. Lyman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 375)

Abstract

Obesity in women can involve predominantly abdominal fat deposition (android) or deposition on the buttocks and thighs (gynoid). Upper body fat localization has been associated with an increased risk of breast and endometrial cancers. The aim of this study was to determine whether calorie reduction and weight loss altered body fat distribution, preferentially reducing abdominal obesity and thus theoretically reducing cancer risk. Anthropometric parameters were determined in 189 apparently healthy, overweight women between ages 21–75. The study demonstrated that 64.2% with at least 4.5 kg weight loss decreased their upper body fat localization as measured by a reduction in suprailliac:thigh skinfold ratios (p ≤ 0.001) and other skinfold thickness indicative of upper body fat reduction such as suprailliac (p ≤ 0.001), subscapular (p ≤ 0.002) and abdomen (p ≤ 0.001) skinfolds. The reduction in estimated cancer risk based on a previously generated multiple logistic regression model was 45% after a 4.5 kg weight loss or more. Greater weight loss further reduced upper body fat localization and estimated breast cancer risk based on this model.

Keywords

Cancer Risk Breast Cancer Risk Endometrial Cancer Abdominal Obesity Multiple Logistic Regression Model 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • N. B. Kumar
    • 1
  • D. V. Schapira
    • 1
  • G. H. Lyman
    • 1
  1. 1.H. Lee Moffitt Cancer Center & Research Institute and University of South Florida College of MedicineTampaUSA

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