Metabolic Alterations and Lactate Overproduction in Insulin-Resistant States

  • Mario Digirolamo
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 375)


Progressive wasting, weakness, anorexia, and anemia are frequent complications of neoplastic disease.1–4 Decreases in adipose mass constitute the major body losses and exceed losses seen in simple starvation. Decreases in protein constituents of the body, however, are also observed.4–5 The mechanisms for depletion of body energy stores are complex and not adequately explained by anorexia, reduced food consumption, or simply by increased energy utilization by tumor tissue.1,2,6


Insulin Resistance Lactate Level Lactate Production Cancer Cachexia Acanthosis Nigricans 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Mario Digirolamo
    • 1
  1. 1.Department of MedicineEmory University School of MedicineAtlantaUSA

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