Vitamin-Regulated Retinoblastoma Tumor Suppressor Gene Expression in Leukemic Cells
Vitamins A and D are well known to perform important functions in growth and development. The mechanisms by which they act at the cellular level to control proliferation and differentiation thus become of importance in understanding how these dietary factors work. Using tissue culture, it has been found that a variety of cultured cells respond in particular to the metabolites, retinoic acid, and 1,25-dihydroxy vitamin D3. These cells have formed convenient experimental systems in which to study the mechanism of action of these metabolites at the molecular level. At this level, it is known that vitamins A and D have receptors that are related as members of the family of steroid-thyroid hormone receptors.1,2 Ligand receptor binding and receptor complex translocation to the nucleus thus regulate gene expression. The ultimate result of a lengthy metabolic cascade initiated this way can be control of cell proliferation or differentiation. The identity and roles of the genes that mediate this metabolic cascade are of obvious interest in understanding the mechanism by which these vitamins or their metabolites act in growth and development.
KeywordsRetinoic Acid Specific Growth Arrest Metabolic Cascade Retinoblastoma Gene Product Nuclear Oncogene
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