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Two Pathways of Evolution of Neurotransmitters-Modulators

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Evolution of the First Nervous Systems

Part of the book series: NATO ASI Series ((NSSA,volume 188))

Abstract

Nature provides many examples of parallel and convergent evolution. For example, two large categories of contractile proteins have evolved in parallel - myosins and tubulins. My thesis is that there have been two parallel pathways of evolution of neurotransmitters and neuromodulators: (1) Amino acids and amines which are formed by simple reactions from amino acids, phospholipid bases and nucleotides; (2) Neuropeptides, which are encoded as long precursors that are later cleaved and may be converted further, post-translationally. In some cells, the two types of neuro-agents co-exist.

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Authors and Affiliations

  1. Department of Physiology and Biophysics, University of Illinois, Urbana, Illinois, 61801, USA

    C. Ladd Prosser

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  1. C. Ladd Prosser
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  1. University of Florida, St. Augustine, Florida, USA

    Peter A. V. Anderson

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© 1989 Springer Science+Business Media New York

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Prosser, C.L. (1989). Two Pathways of Evolution of Neurotransmitters-Modulators. In: Anderson, P.A.V. (eds) Evolution of the First Nervous Systems. NATO ASI Series, vol 188. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0921-3_13

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  • DOI: https://doi.org/10.1007/978-1-4899-0921-3_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0923-7

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