Electrolytes are minerals present in variable concentrations in all biological fluids. They are essential for maintenance of body fluid balance and in the function of all cells, tissues, and organs. The concentration of specific electrolyte ions and the gradients that they establish control the flow of nutrients and fluids between cells and body compartments. This chapter will deal with the major electrolytes influencing hemodynamic behavior and about which the most is known. These include sodium, potassium, calcium, and magnesium. Each electrolyte will be examined in terms of its relative concentrations in various compartments, its effects on biological function, factors influencing its effects on biological function and metabolism, and its role in disease states.


Plasma Renin Activity Sodium Intake Blood Pressure Response Potassium Intake Sodium Loading 
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  1. Belizan, J. M., Villar, J., & Pineda, O. (1983). Reduction of blood pressure with calcium supplementation in young adults. Journal of the American Medical Association, 249, 1161–1165.PubMedCrossRefGoogle Scholar
  2. Brown, M. S., Brown, D. C., & Murphy, M. D. (1983). Hypokalemia from beta 2 receptor stimulation by circulating epinephrine. New England Journal of Medicine, 23, 1414–1419.CrossRefGoogle Scholar
  3. Chen, W. T., Brace, R. A., Scott, J. B., Anderson, D. K., & Haddy, F. J. (1972). The mechanism of the vasodilator action of potassium. Proceedings of the Society for Experimental Biology and Medicine, 140, 820–824.PubMedCrossRefGoogle Scholar
  4. Curry, P., Fitchett, D., & Stubbs, W. (1976). Ventricular arrhythmias and hypokalemia. Lancet, 2, 231–233.PubMedCrossRefGoogle Scholar
  5. Dustan, H. P., Tarazi, R. C., & Bravo, E. L. (1972). Physiologic characteristics of hypertension. American Journal of Medicine, 52, 610–622.PubMedCrossRefGoogle Scholar
  6. Falkner, B., Katz, S., Canessa, M., & Kushner, H. (1986). The response to long-term oral sodium loading in young blacks. Hypertension, 8, I165–I168.Google Scholar
  7. Grim, C. E., Weinberger, M. H., Higgins, J. T., Jr., & Kramer, N. J. (1977). Diagnosis of secondary forms of hypertension: A comprehensive protocol. Journal of the American Medical Association, 237, 1331–1335.PubMedCrossRefGoogle Scholar
  8. Kaplan, N. M. (1986). The calcium deficiency hypothesis of hypertension: A critique. Annals of Internal Medicine, 105, 947–955.PubMedCrossRefGoogle Scholar
  9. Kawasaki, T., Delea, C. S., Bartter, F. C., & Smith, H. (1978). The effect of high sodium intakes on blood pressure and other related variables in human subjects with idiopathic hypertension. American Journal of Medicine, 64, 193–198.PubMedCrossRefGoogle Scholar
  10. Langford, H. G. (1983). Dietary potassium and hypertension: Epidemiologic data. Annals of Internal Medicine, 98, 770–772.PubMedCrossRefGoogle Scholar
  11. Light, K. C., Koepke, J. P., Obrist, P. A., & Willis, P. W. (1983). Psychological stress induces sodium and fluid retention in men at risk for hypertension. Science, 220, 429–431.PubMedCrossRefGoogle Scholar
  12. Luft, F. C., & Weinberger, M. H. (1982). Sodium intake and essential hypertension. Hypertension, 4 (Suppl. III), III14–III19.PubMedGoogle Scholar
  13. Luft, F. C., Rankin, L. I., Bloch, R., Weyman, A. E., Willis, L. R., Murray, R. H., Grim, C. E., & Weinberger, M. H. (1979). Cardiovascular and humoral responses to extremes of sodium intake in normal white and black men. Circulation, 60, 697–703.PubMedCrossRefGoogle Scholar
  14. Luft, F. C., Weinberger, M. H., Grim, C. E., Henry, D. P., & Fineberg, N. S. (1980). Nocturnal urinary electrolyte excretion and its relationship to the renin system and sympathetic activity in normal and hypertensive man. Journal of Laboratory and Clinical Medicine, 95, 395–406.PubMedGoogle Scholar
  15. Lyle, E. M., Melby, C. L., Hyner, G. C., Edmondson, J. W., & Weinberger, M. H. (1987). Blood pressure and metabolic effects of calcium supplementation in normotensive white and black males. Journal of the American Medical Association, 257, 1772–1776.PubMedCrossRefGoogle Scholar
  16. MacGregor, G. A. (1983). Sodium and potassium intake and blood pressure. Hypertension, 5, III79–III84.PubMedGoogle Scholar
  17. MacGregor, G. A. (1985). Sodium is more important than calcium in essential hypertension. Hypertension, 7, 628–637.PubMedCrossRefGoogle Scholar
  18. McCarron, D. A. (1985). Is calcium more important than sodium in the pathogenesis of essential hypertension?. Hypertension, 7, 607–627.PubMedCrossRefGoogle Scholar
  19. McCarron, D. A., & Morris, C. D. (1985). Blood pressure response to oral calcium in persons with mild to moderate hypertension. Annals of Internal Medicine 103(Suppl. 1), 825–831.PubMedCrossRefGoogle Scholar
  20. Rankin, L. I., Henry, D. P., Weinberger, M. H., Gibbs, P. S., & Luft, F. C. (1981). Sodium intake alters the effects of norepinephrine on blood pressure. Hypertension, 3, 650–656.PubMedCrossRefGoogle Scholar
  21. Resnick, L. M., Muller, F. B., & Laragh, J. H. (1986). Calcium-regulating hormones in essential hypertension: Relation to plasma renin activity and sodium metabolism. Annals of Internal Medicine, 105, 649–654.PubMedCrossRefGoogle Scholar
  22. Schambelan, M., Stockigt, J. R., & Bigheri, E. G. (1973). Isolated hypoaldosteronism in adults. New England Journal of Medicine, 287, 573–576.CrossRefGoogle Scholar
  23. Skrabal, F., Herholz, H., Neumayr, M., Hamberger, L., Ledochowski, M., Sporer, H., Hortnagl, N., Schwarz, S., & Schonitzer, D. (1984). Salt sensitivity in humans is linked to enhanced sympathetic responsiveness and to enhanced proximal tubular reabsorption. Hypertension, 6, 152–158.PubMedGoogle Scholar
  24. Stewart, D. E., Ikram, H., Espiner, E. A., & Nicholls, M. G. (1985). Arrhythmiogenic potential of diuretic-induced hypokalemia in patients with mild hypertension and ischemic heart disease. British Heart Journal, 54, 290–297.PubMedCrossRefGoogle Scholar
  25. Tobian, L., Lange, J., Ulm, K., Wold, K., & Iwai, J. (1985). Potassium reduces cerebral hemorrhage and death rate in hypertensive rats, even when blood pressure is not lowered. Hypertension, 7, I110–I114.PubMedCrossRefGoogle Scholar
  26. Weinberger, M. H., Luft, F. C., Bloch, R., Henry, D. P., Pratt, J. H., Weyman, A. E., Rankin, L. I., Murray, R. H., Willis, L. R., & Grim, C. E. (1982). The blood pressure-raising effects of high dietary sodium intake: Racial differences and the role of potassium. Journal of the American College of Nutrition, 1, 139–148.PubMedGoogle Scholar
  27. Weinberger, M. H., Miller, J. Z., Luft, F. C., Grim, C. E., & Fineberg, N. S. (1986). Definitions and characteristics of sodium sensitivity and blood pressure resistance. Hypertension, 8, II127–II134.PubMedGoogle Scholar
  28. Weinberger, M. H., Miller, J. Z., Grim, C. E., Luft, F. C., Fineberg, N. S., & Christian, J. C. (1987). Sodium sensitivity and resistance of blood pressure are associated with different haptoglobin phenotypes. Hypertension, 10, 443–446.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Myron H. Weinberger
    • 1
  1. 1.Department of MedicineIndiana University School of MedicineIndianapolisUSA

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