Cardiovascular and Neuroendocrine Responses to Challenge in Males and Females

  • Patrice G. Saab
Part of the The Springer Series in Behavioral Psychophysiology and Medicine book series (SSBP)


Increasing attention has been given to the role that physiological response to behavioral challenges, i. e., Stressors, may play in the development of cardiovascular disease (see Matthews et al., 1986). Behavioral Stressors typically evoke notable cardiovascular and neuroendocrine responses. To date, preliminary evidence from the literature on both Type A behavior pattern (TABP) and essential hypertension implicates the role of behaviorally induced sympathetically mediated cardiovascular and neuroendocrine responses to mildly challenging Stressors in the subsequent development of disease (for a thorough review, see Krantz & Manuck, 1984).


Systolic Blood Pressure Menstrual Cycle Menstrual Cycle Phase Urinary Catecholamine Neuroendocrine Response 
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  1. Abplanalp, J. M., Livingston, L., Rose, R. M., & Sandwisch, D. (1977). Cortisol and growth hormone responses to psychological stress during the menstrual cycle. Psychosomatic Medicine, 39, 158–177.PubMedGoogle Scholar
  2. Adams, S., Williams, V., & Vessey, M.P. (1981). Cardiovascular disease and hormone replacement treatment. A pilot case control study. British Medical Journal, 282, 1277–1278.CrossRefGoogle Scholar
  3. Anderson, N. B., Williams, R. B., & Lane, J. D. (1984). Cardiovascular responses to mental arithmetic and interpersonal challenge among black female adults. Psychophysiology, 21, 568 (Abstract).Google Scholar
  4. Asian, S., Nelson, L., Carruthers, M., & Lader, M. (1981). Stress and age effects on catecholamines in normal subjects. Journal of Psychosomatic Research, 25, 33–41.CrossRefGoogle Scholar
  5. Awaritefe, A., & Kadiri, A. U. (1982). The state-trait anxiety inventory and sex. Physiology and Behavior, 29, 211–213.PubMedCrossRefGoogle Scholar
  6. Bain, C., Willet, W., Hennekens, S. C., Rosner, B., Belanger, C., & Speizer, F. E. (1981). Use of postmenopausal hormones and risk of myocardial infarction. Circulation, 64, 42–46.PubMedCrossRefGoogle Scholar
  7. Baldwin, S. F., & Clevenger, T. (1980). Effect of speakers’ sex and size of audience on heart rate changes during short impromptu speeches. Psychological Reports, 46, 131–134.CrossRefGoogle Scholar
  8. Bell, G. H., Davidson, J. N., & Scarborough, H. (1968). Textbook of physiology and biochemistry. London: Livingstone.Google Scholar
  9. Berkson, D. M., Stamler, J., & Cohen, D. B. (1964). Ovarian function and coronary atherosclerosis. Clinical Obstetrics and Gynecology, 7, 504–530.CrossRefGoogle Scholar
  10. Bush, T. L., & Barrett-Connor, E. (1985). Noncontraceptive estrogen use and cardiovascular disease. Epidemiologic Reviews, 7, 80–104.Google Scholar
  11. Carroll, D., Turner, J. R., Lee, H. J., & Stephenson, J. (1984). Temporal consistency of individual differences in cardiac response to a video game. Biological Psychology, 19, 81–93.PubMedCrossRefGoogle Scholar
  12. Centerwall, B. A. (1981). Premenopausal hysterectomy and cardiovascular disease. American Journal of Obstetrics and Gynecology, 139, 58–61.PubMedGoogle Scholar
  13. Collins, A., Eneroth, P., & Landgren, B. (1985). Psychoneuroendocrine stress responses and mood as related to the menstrual cycle. Psychosomatic Medicine, 47, 512–526.PubMedGoogle Scholar
  14. Collins, A., & Frankenhaeuser, M. (1978). Stress response in male and female engineering students. Journal of Human Stress, 4, 43–48.PubMedCrossRefGoogle Scholar
  15. Collins, A., Hanson, V., Eneroth, P., Hagenfeldt, K., Lundberg, U., & Frankenhaeuser, M. (1982). Psychophysiological stress responses in postmenopausal women before and after hormonal replacement therapy. Human Neu-robiology, 1, 153–159.Google Scholar
  16. Coronary Drug Project Research Group (1973). The Coronary Drug Project findings leading to discontinuation of the 2.5 mg/day estrogen group. Journal of the American Medical Association, 226, 652–657.CrossRefGoogle Scholar
  17. Cuche, J. L., Kuchel, O., Barbeau, A., & Genest, J. (1975). Sex differences in the urinary catecholamines. Endocrine Research Communications, 2, 549–559.PubMedGoogle Scholar
  18. Dalmaz, Y., & Peyrin, L. (1982). Sex-differences in cate-cholamine metabolites in human urine during development and at adulthood. Journal of Neural Transmission, 54, 193–207.PubMedCrossRefGoogle Scholar
  19. Davidson, L., Vandongen, R., Rouse, I. L., Beilin, L. J., & Tunney, A. (1984). Sex-related differences in resting stimulated plasma noradrenaline and adrenaline. Clinical Science, 67, 347–352.PubMedGoogle Scholar
  20. Emmens, C. W., & Martin, L. (1964). Estrogens. Methods in Hormone Research, 3, 1–8.Google Scholar
  21. Forsman, L., & Lindblad, L. E. (1983). Effect of mental stress on baroreceptor-mediated changes in blood pressure and heart rate and on plasma catecholamines and subjective responses in healthy men and women. Psychosomatic Medicine, 45, 435–445.PubMedGoogle Scholar
  22. Frankenhaeuser, M. (1983). The sympathetic-adrenal and pituitary adrenal response to challenge: Comparison between the sexes. In T. M. Dembroski, T. H. Schmidt, & G. Blumchen (Eds.), Biobehavioral bases of coronary heart disease (pp. 91–105). Basel: Karger.Google Scholar
  23. Frankenhaeuser, M., Dunne, E., & Lundberg, U. (1976). Sex differences in sympathetic-adrenal medullary reactions induced by different Stressors. Psychopharmacology, 47, 1–5.PubMedCrossRefGoogle Scholar
  24. Frankenhaeuser, M., Lundberg, U., & Forsman, L. (1980). Dissociation between sympathetic-adrenal and pituitaryadrenal response to an achievement situation characterized by high controllability: Comparison between Type A and Type B males and females. Biological Psychology, 10, 79–91.PubMedCrossRefGoogle Scholar
  25. Frankenhaeuser, M., von Wright, M. J., Collins, A., von Wright, J., Sedvall, G., & Swahn, C. G. (1978). Sex differences in psychoendocrine reactions to examination stress. Psychosomatic Medicine, 40, 334–343.PubMedGoogle Scholar
  26. Freedman, R. R., Sabharwal, S. C., & Desai, N. (1987). Sex differences in peripheral vascular adrenergic receptors. Circulation Research, 61, 581–585.PubMedCrossRefGoogle Scholar
  27. Frey, M. A., & Siervogel, R. M. (1983). Cardiovascular response to a mentally stressful stimulus. Japan Heart Journal, 24, 315–323.CrossRefGoogle Scholar
  28. Gackenbach, J. (1982). Collegiate swimmers: Sex differences in self-reports and indices of physiological stress. Perceptual and Motor Skills, 55, 555–558.PubMedCrossRefGoogle Scholar
  29. Garrett, K. F., & Elder, S. T. (1984). The menstrual cycle from a bio-behavioral approach: A comparison of oral contraceptive and non-contraceptive users. International Journal of Psychophysiology, 1, 209–214.PubMedCrossRefGoogle Scholar
  30. Gasul, B. M., Arcilla, R. A., & Lev, M. (Eds.). (1966). Heart disease in children: Diagnosis and treatment. Philadelphia: Lippincott.Google Scholar
  31. Goldstein, D. S., Levinson, P., & Keiser, H. R. (1983). Plasma and urinary catecholamines during the human ovulatory cycle. American Journal of Obstetrics, 146, 824–829.Google Scholar
  32. Graham, L. A., Cohen, S. I., & Shavonian, B. M. (1966). Sex differences in autonomic responses during instrumental conditioning. Psychosomatic Medicine, 28, 264–271.PubMedGoogle Scholar
  33. Hastrup, J. L., Kraemer, D. L., & Phillips, S. M. (1986, October). Blood pressure and heart rate of women under 45 with total hysterectomy: Effects and stress and family history of hypertension. Presentation at the annual meeting of the Society for Psychophysiological Research, Montreal.Google Scholar
  34. Hastrup, J. L., & Light, K. C. (1984). Sex differences in cardiovascular stress responses: Modulation as a function of menstrual cycle phases. Journal of Psychosomatic Research, 28, 475–483.PubMedCrossRefGoogle Scholar
  35. Hjortland, M. C., McNamara, P. M., & Kannel, W. B. (1976). Some atherogenic concomitants of menopause: The Framingham study. American Journal of Epidemiology, 103, 304–311.PubMedGoogle Scholar
  36. Holmes, D. S., Solomon, S., & Rump, B. S. (1982). Cardiac and subjective response to cognitive challenge and to controlled physical exercise by male and female coronary prone (Type A) and noncoronary prone persons. Journal of Psychosomatic Research, 26, 309–316.PubMedCrossRefGoogle Scholar
  37. Houston, B. K. (1986). Psychological variables and cardiovascular and neuroendocrine reactivity. In K. A. Matthews, S. M. Weiss, T. Detre, T. M. Dembroski, B. Falkner, S. B. Manuck, & R. B. Williams, Jr. (Eds.), Handbook of stress, reactivity, and cardiovascular disease (pp. 207–230). New York: Wiley.Google Scholar
  38. Jick, H., Dinan, B., & Rothman, K. J. (1978). Oral contraceptive, and nonfatal myocardial infarction. Journal of the American Medical Association, 239, 1403–1406.PubMedCrossRefGoogle Scholar
  39. Johansson, G. (1972). Sex differences in the catecholamine output of children. Acta Physiologica Scandinavia, 85, 569–572.CrossRefGoogle Scholar
  40. Johansson, G., Frankenhaeuser, M., & Magnussen, J. (1973). Catecholamine output in school children as related to performance and adjustment. Scandinavian Journal of Psychology, 14, 20–28.PubMedCrossRefGoogle Scholar
  41. Johansson, G., & Post, B. (1974). Catecholamine output of males and females over a year period. Acta Physiologica Scandinavia, 92, 557–565.CrossRefGoogle Scholar
  42. Jorgensen, R. S., & Houston, B. K. (1981). Family history of hypertension, gender, and cardiovascular reactivity and stereotypy during stress. Journal of Behavioral Medicine, 4, 175–189.PubMedCrossRefGoogle Scholar
  43. Kannel, W. B., Hjortland, M. C., McNamara, P. M., & Gordon, T. (1976). Menopause and risk of cardiovascular disease. Annals of Internal Medicine, 85, 447–452.PubMedCrossRefGoogle Scholar
  44. Klaiber, E. L., Broverman, D. M., Haffajee, L. I., Hochman, J. S., Sacks, G. M., & Dalen, D. J. E. (1982). Serum estrogen levels in men with acute myocardial infarction. American Medical Journal, 73, 872–880.CrossRefGoogle Scholar
  45. Krantz, D. S., & Manuck, S. B. (1984). Acute psychophysiological reactivity and risk of cardiovascular disease: A review and methodologic critique. Psychological Bulletin, 96, 435–464.PubMedCrossRefGoogle Scholar
  46. Ladisich, W. (1977). Influence of progesterone on serotonin metabolism: A possible causal factor for mood changes. Psy-choneuroendocrinology, 2, 257–266.CrossRefGoogle Scholar
  47. Lamprecht, L., Matta, R. J., Little, B., & Zahn, T. P. (1974). Plasma dopamine-beta-hydroxylase (DBH) activity during the menstrual cycle. Psychosomatic Medicine, 36, 304–310.PubMedGoogle Scholar
  48. Lane, J. D., White, A. D., & Williams, R. B., Jr. (1984). Cardiovascular effects of mental arithmetic in Type A and Type B females. Psychophysiology, 21, 39–46.PubMedCrossRefGoogle Scholar
  49. Lawler, K. A., Allen, M. T., Critcher, E. C., & Standard, B. A. (1981). The relationship of physiological responses to coronary-prone behavior pattern in children. Journal of Behavioral Medicine, 4, 203–216.PubMedCrossRefGoogle Scholar
  50. Lawler, K. A., Rixse, A., & Allen, M. T. (1983). Type A behavior and psychophysiological responses in adult women. Psychophysiology, 20, 343–350.PubMedCrossRefGoogle Scholar
  51. Lawler, K. A., & Schmied, L. A. (1986). Cardiovascular responsivity, Type A behavior and parental history of heart disease in young women. Psychophysiology, 23, 28–32.PubMedCrossRefGoogle Scholar
  52. Lawler, K. A., Schmied, L., Mitchell, V. P., & Rixse, A. (1984). Type A behavior and physiological responsivity in young women. Journal of Psychosomatic Research, 28, 197–204.PubMedCrossRefGoogle Scholar
  53. Lenney, E. (1977). Women’s self-confidence in achievement settings. Psychological Bulletin, 84, 1–13.CrossRefGoogle Scholar
  54. Liberson, C. W., & Liberson, W. T. (1975). Sex differences in autonomic responses to electric shock. Psychophysiology, 12, 182–186.PubMedCrossRefGoogle Scholar
  55. Little, B. C., & Zahn, T. P. (1974). Changes in mood and autonomic functioning during menstrual cycle. Psychophysiology, 11, 579–590.PubMedCrossRefGoogle Scholar
  56. Lobo, R., Shoupe, D., Roy, S., & Wellington, P. (1984). Central and peripheral metabolites of norepinephrine and dopamine in postmenopausal women. American Journal of Obstetrics and Gynecology, 149, 548–552.PubMedGoogle Scholar
  57. Lucisano, A. A., Campora, M. E., Russo, N., Maniccia, E., Montemurro, A., & Dell’Acqua, S. (1984). Ovarian and peripheral plasma levels of progestins, androgens and estrogens in post-menopausal women. Maturitas, 6, 45–53.PubMedCrossRefGoogle Scholar
  58. Lundberg, E., & Frankenhaeuser, M. (1980). Pituitary-adrenal and sympathetic-adrenal correlates of distress and effort. Journal of Psychosomatic Research, 24, 125–130.PubMedCrossRefGoogle Scholar
  59. MacDougall, J. M., Dembroski, T. M., & Krantz, D. S. (1981). Effects of types of challenge on pressor and heart rate responses in Type A and B women. Psychophysiology, 18, 1–9.PubMedCrossRefGoogle Scholar
  60. Mann, J. I., & Inman, W. H. W. (1975). Oral contraceptives and death from myocardial infarction. British Medical Journal, 2, 245–248.PubMedCrossRefGoogle Scholar
  61. Mann, J. I., Inman, W. H. W., & Thorogood, M. (1976). Oral contraceptive use in older women and fatal myocardial infarction. British Medical Journal, 2, 445–449.PubMedCrossRefGoogle Scholar
  62. Manuck, S. B., Craft, S., & Gold, K. J. (1978). Coronaryprone behavior pattern and cardiovascular response. Psychophysiology, 15, 403–411.PubMedCrossRefGoogle Scholar
  63. Marinan, K. T., Leshner, A. I., & Doyle, M. P. (1976). Menstrual cycle status and adrenocortical reactivity to psychological stress. Psychoneuroendocrinology, 1, 213–218.CrossRefGoogle Scholar
  64. Matthews, K. A. (1982). Psychological perspectives on the Type A behavioral pattern. Psychological Bulletin, 91, 293–323.PubMedCrossRefGoogle Scholar
  65. Matthews, K. A., Weiss, S. M., Detre, T., Dembroski, T. M., Falkner, B., Manuck, S. B., & Williams, R. B., Jr. (Eds.). (1986). Handbook of stress, reactivity and cardiovascular disease. New York: Wiley.Google Scholar
  66. McConathy, W. J., & Alaupovic, P. (1981). Effects of estrogens on the plasma lipoprotein system in menopausal and postmenopausal women. In R. M. Greenshalgh (Ed.), Hormones and vascular disease (pp. 319–330). London: Pitman Press.Google Scholar
  67. Myrstern, A. L., Lundberg, U., Frankenhaeuser, M., Ryan, G., Dolphin, C., & Cullen, J. (1984). Sex-role orientation as related to psychological and physiological responses during achievement and orthostatic stress. Motivation and Emotion, 8, 243–258.CrossRefGoogle Scholar
  68. National Center for Health Statistics (1977). Blood pressure levels of persons 6-74 years of age. United States 1971-1974. Vital and Health Statistics, 11, 203.Google Scholar
  69. Neus, H., & von Eiff, A. W. (1985). Selected topics in the methodology of stress testing: Time course, gender and adaptation. In A. Steptoe, H. Ruddel, & H. Neus (Eds.), Clinical and methodological issues in cardiovascular psychophysiology (pp. 78–92). Berlin: Springer-Verlag.CrossRefGoogle Scholar
  70. Patkai, P., Johansson, G., & Post, B. (1974). Mood alertness and sympathetic-adrenal medullary activity during the menstrual cycle. Psychosomatic Medicine, 36, 503–512.PubMedGoogle Scholar
  71. Phillips, G. B. (1978). Sex, hormones, risk factors and carii.Google Scholar
  72. Polefrone, J. M., & Manuck, S. B. (1988). Effects of menstrual phase and parental history of hypertension on cardiovascular response to cognitive challenge. Psychosomatic Medicine, 50, 23–36.PubMedGoogle Scholar
  73. Prosser, C. L. (1973). Comparative animal physiology (3rd ed.). Philadelphia: Saunders.Google Scholar
  74. Rauste-von Wright, M., von Wright, J., & Frankenhaeuser, M. (1981). Relationships between sex-related psychological characteristics during adolescence and catecholamine excretion during achievement stress. Psychophysiology, 18, 362–370.PubMedCrossRefGoogle Scholar
  75. Rosenberg, L., Armstrong, B., & Jick, H. (1976). Myocardial infarction and estrogen therapy in post-menopausal women. New England Journal of Medicine, 294, 1256–1259.PubMedCrossRefGoogle Scholar
  76. Royal College of General Practioners’ Oral Contraception Study (1981). Further analyses of mortality in oral contraceptive users. Lancet, 1, 541–546.Google Scholar
  77. Saab, P. G., Matthews, K. A., Stoney, C. M., McDonald, R. H. (in press). Premenopausal and postmenopausal women differ in their cardiovascular and neuroendocrine responses to behavioral Stressors. Psychophysiology.Google Scholar
  78. Schlaadt, R. G., & Shannon, P. T. (1986). Drugs of choice. Englewood Cliffs, NJ: Prentice-Hall.Google Scholar
  79. Stamfer, M. J., Willett, W. C., Colditz, G. A., Rosner, B., Speizer, F. E., & Hennekens, C. H. (1985). A prospective study of postmenopausal estrogen therapy and coronary heart disease. The New England Journal of Medicine, 313, 1044–1049.CrossRefGoogle Scholar
  80. Stamler, J. (1975). Epidemiology of hypertension: Achievements and challenges. In M. Moser (Ed.), Hypertension: A practical approach (pp. 1–43). Boston: Little, Brown.Google Scholar
  81. Stern, M. P., Brown, B. W., Haskell, W. L.; Farquhar, J. W., Wehrle, C. L., & Wood, D. S. (1976). Cardiovascular risk and use of estrogens or estrogen/progesteron combinations. Journal of the American Medical Association, 235, 811–815.PubMedCrossRefGoogle Scholar
  82. Stoney, C. M., Langer, A. W., & Gelling, P. D. (1986). The effects of menstrual cycle phase on cardiovascular and pulmonary responses to behavioral and exercise stress. Psychology, 23, 393–402.Google Scholar
  83. Stout, R. (1982). Hormones and atherosclerosis. Lancaster: MTP Press.CrossRefGoogle Scholar
  84. Tennes, K., & Kreye, M. (1985). Children’s adrenocortical responses to classroom activities and tests in elementary school. Psychosomatic Medicine, 47, 451–460.PubMedGoogle Scholar
  85. Tracy, R. E. (1966). Sex difference in coronary disease: Two opposing views. Journal of Chronic Diseases, 19, 1245–1251.PubMedCrossRefGoogle Scholar
  86. Van Egeren, L. F. (1979). Cardiovascular changes during social competition in a mixed motive game. Journal of Personality and Social Psychology, 37, 858–864.PubMedCrossRefGoogle Scholar
  87. Vermeulen, A. (1976). The hormonal activity of the post menopausal ovary. Journal of Clinical Endocrinology and Metabolism, 42, 247–253.PubMedCrossRefGoogle Scholar
  88. Vessey, M., Doll, R., Peto, R., Johnson, B., & Wiggins, P. (1976). A long-term-follow-up study of women using different methods of contraception—An interim report. Journal of Biosocial Sciences, 8, 373–427.CrossRefGoogle Scholar
  89. von Eiff, A. W., Plotz, E. J., Beck, K. J., & Czernik, A. (1971). The effect of estrogens and progestins on blood pressure regulation of normotensive women. American Journal of Obstetrics and Gynecology, 109, 887–892.Google Scholar
  90. Wasilewska, E., Kobus, E., & Bargiel, Z. (1980). Urinary catecholamine excretion and plasma dopamine-beta-hydrox-ylase activity in mental work performed in two periods of menstrual cycle in women. In E. Usdin, R. Kvetansky, & I. J. Kopin (Eds.), Stress and catecholamines: Recent advances (pp. 549–554). Amsterdam: Elsevier/North-Holland.Google Scholar
  91. Williams, R. B., Lane, J. D., Kuhn, C. M., Melosh, W., White, A. R., & Schanberg, S. M. (1982). Type A behavior and elevated physiological and neuroendocrine response to cognitive tasks. Science, 218, 483–485.PubMedCrossRefGoogle Scholar
  92. Wren, B. G., & Routledge, A. D. (1981). Blood pressure changes: Oestrogens in climacteric women. Medical Journal of Australia, 2, 528–531.PubMedGoogle Scholar
  93. Zacur, H. A., Tyson, J. E., Ziegler, M. G., & Lake, C. R. (1978). Plasma dopamine-β-hydroxylase activity and nor-epinephrine levels during the human menstrual cycle. American Journal of Obstetrics and Gynecology, 130, 148–151.Google Scholar
  94. Zuspan, F. P., & Zuspan, K. J. (1973). Ovulatory plasma amine (epinephrine and norepinephrine) surge in the woman. American Journal of Obstetrics and Gynecology, 117, 654–660.PubMedGoogle Scholar

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© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Patrice G. Saab
    • 1
  1. 1.Department of PsychologyUniversity of MiamiCoral GablesUSA

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