Abstract
The nature of ambulatory blood pressure (BP) monitoring is such that exploratory data analysis is both useful and necessary. In any study using ambulatory monitoring there are many sources of uncontrolled variability, including individual levels of BP, individual diurnal patterns of BP, individual physical activity patterns, individual mental activity (psychological) patterns, and artifactual readings. Failure to properly account for these sources of variation will typically obscure real effects in the data and can bias the estimates of the effects of primary interest. In this chapter we report our experience with the exploratory analysis which should precede the calculation of p values. Our experience has been primarily with large samples. When the sample size is large, computing resources can be severely strained and statistical significance (via a p value) takes a backseat to practical significance. We do not discuss the interpretation of significance tests in any detail but refer readers to the discussions by Ware, Mosteller, and Ingelfinger (1986) and Royall (1986).
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References
Becker, R.A., & Chambers, J. M. (1984). S: An interactive environment for data analysis and graphics. Belmont, CA: Wadsworth.
Clark, L. A., Denby, L., Pregibon, D., Harshfield, G. A., Pickering, T. G., Blank, S., & Laragh, J. H. (1987a). A data based method for bivariate outlier detection: Application to automatic blood pressure recording devices. Psychophysiology, 24, 119–125.
Clark, L. A., Denby, L., Pregibon, D., Harshfield, G. A., Pickering, T. G., Blank, S., & Laragh, J. H. (1987b). A quantitative analysis of the effects of activity and time of day on the diurnal variations of blood pressure. Journal of Chronic Diseases, 40, 671–681.
Cleveland, W. S. (1985). The elements of graphing data. Belmont, CA: Wadsworth.
Collomb, G. (1981). Estimation Non-Parametrique de la Regression: Revue Bibliographique. International Statistics Review, 49, 75–94.
Draper, N. R., & Smith, H. (1981). Applied regression analysis. New York: Wiley.
Halberg, F., Halberg, E., Halberg, J., & Halberg, F. (1984). Chronobiologic assessment of human blood pressure variation in health and disease. In M. A. Weber & J. I. M. Drayer (Eds.), Ambulatory blood pressure monitoring (pp. 137–156). Berlin: Springer-Verlag.
Hastie, T., & Tibshirani, R. (1986). Generalized additive models (with discussion). Statistical Science, 1, 297–318.
Healy, M. J. R. (1968). Multivariate normal plotting. Applied Statistics, 17, 157–161.
Marier, M. A., Jacob, R. G., Lehoczky, J. P., & Shapiro, A. P. (1988). The statistical analysis of treatment effects in 24-hour ambulatory blood pressure recordings. Statistics in Medicine, 7, 697–716.
McDonald, J. A. (1986). Periodic smoothing of time series. SIAM Journal of Scientific and Statistical Computing, 7, 665–688.
Millar-Craig, M. W., Bishop, C. N., & Raftery, E. B. (1978). Orcadian variation of blood pressure. Lancet, 1, 795.
Millar-Craig, M. W., Mann, S., Balasubramanian, V., & Raftery, E. G. (1978). Blood pressure circadian rhythm in essential hypertension. Clinical Science and Molecular Medicine, 55, 391s.
Royall, R. M. (1986). The effect of sample size on the meaning of significance tests. American Statistician, 40, 313–315.
Snedecor, G. W., & Cochran, W. G. (1967). Statistical methods (6th ed.). Ames: Iowa State University Press.
Ware, J. H., Mosteller, F., & Ingelfinger, J. A. (1986). P values. In J. C. Bailar, III, & F. Mosteller (Eds.), Medical uses of statistics. Waltham, MA: NEJM Books.
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Clark, L.A., Denby, L., Pregibon, D. (1989). Data Analysis of Ambulatory Blood Pressure Readings. In: Schneiderman, N., Weiss, S.M., Kaufmann, P.G. (eds) Handbook of Research Methods in Cardiovascular Behavioral Medicine. The Springer Series in Behavioral Psychophysiology and Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0906-0_21
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DOI: https://doi.org/10.1007/978-1-4899-0906-0_21
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