The Renin—Angiotensin—Aldosterone System and Atrial Natriuretic Factor

  • Steven A. Atlas
  • Jean E. Sealey
  • John H. Laragh
Part of the The Springer Series in Behavioral Psychophysiology and Medicine book series (SSBP)


The purpose of this chapter is to provide an overview of physiological, biochemical, and methodological considerations concerning two hormonal systems that appear to play opposing roles in the physiological regulation of the circulation. Emphasis is placed on those issues pertinent to the needs of investigators involved in cardiovascular and behavioral research, in terms of selection of methods, adequacy of experimental design, and interpretation of data. The bulk of the information presented is directed toward assessment of hormone levels in blood or urine, but brief consideration is also given to measurements in other tissues which might be entertained in certain experimental studies. In addition, a description is given of available pharmacological probes which can be used to assess the functional significance of these hormones.


Atrial Natriuretic Peptide Plasma Renin Primary Aldosteronism Plasma Aldosterone Atrial Natriuretic Factor 
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Steven A. Atlas
    • 1
  • Jean E. Sealey
    • 1
  • John H. Laragh
    • 1
  1. 1.Cardiovascular Center and Department of MedicineCornell University Medical CollegeNew YorkUSA

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