Skip to main content
SpringerLink
Log in

Receptors

  • Chapter
Book cover Handbook of Research Methods in Cardiovascular Behavioral Medicine

Abstract

In the past ten years, binding sites for more than two dozen neurotransmitters and hormones have been identified. With the exception of the thyroid and steroid hormone receptors, all neurotransmitter and peptide receptors have thus far been localized to the cell surface of the target organ. It has become clear that the membranes of most cells are endowed with a remarkably heterogeneous population of receptor sites.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 259.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Aarons, R. D., Nies, A. S., Gal, J., Hegstrand, L. R., & Molinoff, P. B. (1980). Elevation of beta-adrenergic receptor density in human lymphocytes after propranolol administration. Journal of Clinical Investigation, 65, 949–957.

    Article  PubMed  CAS  Google Scholar 

  • Alexander, R. W. (1987). Adrenergic receptors in cardiovascular disease. In P. A. Insel (Ed.), Adrenergic receptors in man. New York: Dekker.

    Google Scholar 

  • Andersson, R. G. G., Nilsson, O. R., & Kuo, J. F. (1983). Beta-adrenoceptor-adenosine 3′-5′ monophosphate system in human leukocytes before and after treatment for hyperthyroidism. Journal of Clinical Endocrinology and Metabolism, 56, 42–45.

    Article  PubMed  CAS  Google Scholar 

  • Ariëns, E. J. (1954). Affinity and intrinsic activity in the theory of competitive inhibition. Part I. Problems and theory. Archives Internationales de Pharmacodynamie, 99, 32–49.

    Google Scholar 

  • Banerjee, S. P., Kung, L. S., Riggi, S. J., & Chanda, S. K. (1977). Development of beta adrenergic receptor subsensitivity by antidepressants. Nature, 268, 455–456.

    Article  PubMed  CAS  Google Scholar 

  • Bannister, R., Boylston, A. W., Davies, I. B., Mathias, C. J., Sever, P. S., & Sudera, D. (1981). Beta-receptor numbers and thermodynamics in denervation supersensitivity. Journal of Physiology (London) 319, 369–377.

    CAS  Google Scholar 

  • Benovic, J. L., Mayor, F., Jr., Somers, R. L., Caron, M. G., & Lefkowitz, R. J. (1986). Light-dependent phosphorylation of rhodopsin by β-adrenergic receptor kinase. Nature, 321, 869–872.

    Article  PubMed  CAS  Google Scholar 

  • Berthelsen, S., & Pettinger, W. A. (1977). A functional basis for classification of α-adrenergic receptors. Life Sciences, 21, 595–606.

    Article  PubMed  CAS  Google Scholar 

  • Bilezikian, J. P., & Loeb, J. N. (1983). The influence of hyperthyroidism and hypothyroidism on alpha-and beta-adrenergic receptor systems and adrenergic responsiveness. Endocrine Reviews, 4, 378–388.

    Article  PubMed  CAS  Google Scholar 

  • Boon, N. A., Elliott, J. M., Davies, C. L., Conway, F. J., Jones, J. V., Grahame-Smith, D. G., & Sleight, P. (1983). Platelet α2-adrenoreceptors in borderline and established essential hypertension. Clinical Science, 65, 207–208.

    PubMed  CAS  Google Scholar 

  • Bourne, H. R. (1986). One molecular machine can transduce diverse signals. Nature, 321, 814–816.

    Article  PubMed  CAS  Google Scholar 

  • Bravo, E. L., Tarazi, R. C., Gifford, R. W., & Stewart, B. H. (1979). Circulating and urinary catecholamines in pheochromocytoma. Diagnostic and pathophysiologic implications. New England Journal of Medicine, 301, 682.

    Article  PubMed  CAS  Google Scholar 

  • Brodde, O.-E. (1986). Molecular pharmacology of β-adrenoceptors. Journal of Cardiovascular Pharmacology, 8 (Suppl. 4), S16–S20.

    Article  PubMed  CAS  Google Scholar 

  • Brodde, O.-E., Daul, A., & O’Hara, N. (1984). Beta-adrenoceptor changes in human lymphocytes induced by dynamic exercise. Naunyn-Schmiedebergs Archives of Pharmacology, 325, 190.

    Article  CAS  Google Scholar 

  • Brodde, O.-E., Daul, A. E., O’Hara, N., & Khalifa, A. M. (1985). Properties of α-and β-adrenoceptors in circulating blood cells of patients with essential hypertension. Journal of Cardiovascular Pharmacology, 7 (Suppl. 6), S162–S167.

    Article  PubMed  Google Scholar 

  • Bürgisser, E., Raine, A. E. G., Erne, P., Kamber, B., & Bühler, F. R. (1986). Human cardiac plasma concentrations of atrial natriuretic peptide quantified by radioreceptor assay. Biochemical and Biophysical Research Communications, 133, 1201–1209.

    Article  Google Scholar 

  • Butler, J., Kelly, J. G., O’Malley, K., & Pidgeon, F. (1983). Beta-adrenergic adaptation to acute exercise. Journal of Physiology (London), 344, 1131.

    Google Scholar 

  • Cameron, O. G., Smith, C. B., Hollingsworth, P. J., Nesse, R. M., & Curtis, G. C. (1984). Platelet α2 adrenergic receptor binding and plasma catecholamines. Archives of General Psychiatry, 41, 1144–1148.

    Article  PubMed  CAS  Google Scholar 

  • Chobanian, A. V., Tifft, C. P., Sackel, H., & Pitruzella, A. (1982). Alpha and beta adrenergic receptor activity in circulating blood cells of patients with idiopathic orthostatic hypotension and pheochromocytoma. Clinical and Experimental Hypertension, A4, 793–806.

    Article  Google Scholar 

  • Cognini, G., Piantanelli, L., Paolinelli, E., Orlandoni, P., Pelligrini, A., & Masera, N. (1983). Decreased beta-adrenergic receptor density in mononuclear leukocytes from thyroidectomized patients. Acta Endocrinologica, 103, 1–5.

    Google Scholar 

  • Colucci, W. S., Alexander, R. W., Williams, G. H., Rude, R. E., Holman, B. L., Konstam, M. A., Wynne, J., Mudge, G. H., Jr., & Braunwald, E. (1981). Decreased lymphocyte beta-adrenergic receptor density in patients with heart failure and tolerance to the beta-adrenergic agonist pirbuterol. New England Journal of Medicine, 305, 185–189.

    Article  PubMed  CAS  Google Scholar 

  • Cryer, P. E. (1987). Adrenergic receptors in endocrine and metabolic diseases. In P. A. Insel (Ed.), Adrenergic receptors in man (pp. 285–301). New York: Dekker.

    Google Scholar 

  • Cundell, D., Danks, J., Phillips, M. J., & Davies, R. J. (1984). Effect of exercise on isoprenaline-induced lymphocyte cAMP production in atopic asthmatics and atopic and non-atopic, non-asthmatic subjects. Clinical Allergy, 24, 433.

    Google Scholar 

  • Daiguji, M., Meltzer, H. Y., Tang, C., & U’Prichard, D. C. (1981). Alpha-2-adrenergic receptors in platelet membranes of depressed patients: No change in number of 3H-yohimbine affinity. Life Sciences, 29, 2059–2064.

    Article  PubMed  CAS  Google Scholar 

  • Davies, I. B., Sudera, D., Sagnella, G., Marchesi-Saviotti, E., Mathias, C., Bannister, R., & Sever, P. (1982). Increased numbers of alpha receptors in sympathetic denervation supersensitivity in man. Journal of Clinical Investigation, 69, 779–784.

    Article  PubMed  CAS  Google Scholar 

  • DeBlasi, A., Lipartiti, M., Motulsky, H. J., Insel, P. A., & Fratelli, M. (1985). Agonist-induced redistribution of betaadrenergic receptors on intact human mononuclear leukocytes: Redistributed receptors are nonfunctional. Journal of Clinical Endocrinology and Metabolism, 61, 1081.

    Article  CAS  Google Scholar 

  • DeBlasi, A., Cotecchia, S., Fratelli, M., & Lipartiti, M. (1986). Agonist-induced beta-adrenoceptor internalization of intact human mononuclear leukocytes: Effects of temperature of mononuclear separation. Journal of Laboratory and Clinical Medicine, 107, 86.

    CAS  Google Scholar 

  • DeBlasi, A., Maisel, A. S., Feldman, R. D., Ziegler, M. G., Fratelli, M., Dilallo, M., Smith, D. A., Lai, C. Y. C., & Motulsky, H. J. (1986). In vivo regulation of β-adrenergic receptors on human mononuclear leukocytes: Assessment of receptor number, location, and function after posture change, exercise, and isoproterenol infusion. Journal of Clinical Endocrinology and Metabolism, 63, 847–853.

    Article  PubMed  CAS  Google Scholar 

  • DeLean, A., Hancock, A. A., & Lefkowitz, R. J. (1982). Validation and statistical analysis of a computer modeling method for quantitative analysis of radioligand-binding data for mixtures of pharmacological receptor subtypes. Molecular Pharmacology, 21, 5–16.

    CAS  Google Scholar 

  • DeLean, A., Racz, K., Gutkowska, J., Nguyen, T.-T., Cantin, M., & Genest, J. (1984). Specific receptor-mediated inhibition by synthetic atrial natriuretic factor of hormonestimulated steroidogenesis in cultured bovine adrenal cells. Endocrinology, 115, 1636–1638.

    Article  CAS  Google Scholar 

  • Docherty, J. R., & O’Malley, K. (1985). Aging and alphaadrenoceptors. Clinical Science, 68 (Suppl. 10), 133S–136S.

    PubMed  Google Scholar 

  • Edwards, A. J., Bacon, T. H., Elms, C. A., Verardi, R., Felder, M., & Knight, S. C. (1984). Changes in the populations of lymphoid cells in human peripheral blood following physical exercise. Clinical and Experimental immunology, 58, 420.

    PubMed  CAS  Google Scholar 

  • Engel, G., Hoyer, D., Berthold, R., & Wagner, H. (1981). (±)-125Iodocyanopindolol, a new ligand for β-adrenoceptors: Identification and quantitation of subclasses of β-adrenoceptors in guinea-pig. Naunyn-Schmiedeberg’s Archives of Pharmacology, 317, 277–285.

    Article  PubMed  CAS  Google Scholar 

  • Farde, L., Hall, H., Ehrin, E., & Sedvall, G. (1986). Quantitative analysis of D2 dopamine receptor binding in the living human brain by PET. Science, 231, 258–261.

    Article  PubMed  CAS  Google Scholar 

  • Feldman, R. D., Limbird, L. E., Nadeau, J. H., FitzGerald, G. A., Robertson, D., & Wood, A. J. J. (1983). Dynamic regulation of leukocyte beta adrenergic receptor-agonist interactions by physiological changes in circulating catecholamines. Journal of Clinical Investigation, 72, 164.

    Article  PubMed  CAS  Google Scholar 

  • Feldman, R. D., Limbird, L. E., Nadeau, J. H. J., Robertson, D., & Wood, A. J. J. (1984a). Alterations in leukocyte β-receptor affinity with aging: A potential explanation for altered β-adrenergic sensitivity in the elderly. New England Journal of Medicine, 310, 815–819.

    Article  PubMed  CAS  Google Scholar 

  • Feldman, R. D., Limbird, L. E., Nadeau, J. H., Robertson, D., & Wood, A. J. J. (1984b). Leukocyte beta-receptor alterations in hypertensive subjects. Journal of Clinical Investigation, 73, 648.

    Article  PubMed  CAS  Google Scholar 

  • Fraser, J. A., Nadeau, J. H. J., Robertson, D., & Wood, A. J. J. (1981). Regulation of human leukocyte beta receptors by endogenous catecholamines: Relationship of leukocyte beta receptor density to the cardiac sensitivity to isoproterenol. Journal of Clinical Investigation, 67, 1777–1784.

    Article  PubMed  CAS  Google Scholar 

  • Gaddum, J. H. (1957). Theories of drug antagonism. Pharmacological Reviews, 9, 211–217.

    PubMed  CAS  Google Scholar 

  • Garcia-Sevilla, J. A., Zia, A. P., Hollingsworth, P. J., Greden, J. F., & Smith, C. B. (1981). Platelet alpha2-adrenergic receptors in major depressive disorder: Binding of tritiated clonidine before and after tricyclic antidepressant drug treatment. Archives of General Psychiatry, 38, 1327–1333.

    Article  PubMed  CAS  Google Scholar 

  • Garnett, E. S., Firnau, G., & Nahmias, C. (1983). Dopamine visualized in the basal ganglia of living man. Nature, 305, 137–138.

    Article  PubMed  CAS  Google Scholar 

  • Ginsberg, A. M., Clutter, W. E., Shah, S. D., & Cryer, P. E. (1981). Triiodothyronine-induced thyrotoxicosis increases mononuclear leukocyte beta-adrenergic receptor density in man. Journal of Clinical Investigation, 67, 1785–1791.

    Article  PubMed  CAS  Google Scholar 

  • Goldberg, M. R., & Robertson, D. (1983). Yohimbine: A pharmacological probe for study of the α2-adrenergic receptor. Pharmacological Reviews, 35, 143–180.

    PubMed  CAS  Google Scholar 

  • Goldberg, M. R., & Robertson, D. (1984). Evidence for the existence of vascular α2-adrenoreceptors in man. Hypertension, 6, 551–556.

    Article  PubMed  CAS  Google Scholar 

  • Goldberg, M. R., Curatolo, P. W., Tung, C. S., & Robertson, D. (1982). Caffeine down-regulates β-adrenoreceptor density in rat forebrain. Neuroscience Letters, 31, 47–52.

    Article  PubMed  CAS  Google Scholar 

  • Goldberg, M. R., Hollister, A. S., & Robertson, D. (1983). Influence of yohimbine on blood pressure, autonomic reflexes and plasma catecholamines. Hypertension, 5, 772–778.

    Article  PubMed  CAS  Google Scholar 

  • Goldstein, A., Aronow, L., & Kaiman, S. M. (1974). Principles of drug action: The basis of pharmacology (2nd ed., pp. 82–111). New York: Wiley.

    Google Scholar 

  • Greenacre, J. K., & Conolly, M. E. (1978). Desensitization of the beta-adrenoceptor of lymphocytes from normal subjects and patients with phaeochromocytoma: Studies in vivo. British Journal of Pharmacology, 5, 191–197.

    Article  CAS  Google Scholar 

  • Grenningloh, G., Rienitz, A., Schmitt, B., Methfessel, C., Zensen, M., Beyreuther, K., Gundelfinger, E. D., & Betz, H. (1987). The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors. Nature, 328, 215–220.

    Article  PubMed  CAS  Google Scholar 

  • Guarnieri, T., Filburn, C. R., Zitnik, G. S., & Lakatta, E. G. (1980). Contractile and biochemical correlates of beta-adrenergic stimulation of the aged heart. American Journal of Physiology, 239, H501–H508.

    PubMed  CAS  Google Scholar 

  • Hantraye, P., Loc’h, C., Tacke, U., Riche, D., Stulzaft, O., Doudet, D., Guibert, B., Naquet, R., Maziere, B., & Maziere, M. (1986). “In vivo” visualization by positron emission tomography of the progressive striatal dopamine receptor damage occurring in MPTP-intoxicated non-human primates. Life Sciences, 39, 1376–1378.

    Article  Google Scholar 

  • Harden, T. K. (1983). Agonist-induced desensitization of the beta-adrenergic receptor-linked adenylate cyclase. Pharmacological Reviews, 35, 5.

    PubMed  CAS  Google Scholar 

  • Hoeldtke, R. D., & Climi, K. M. (1985). Effects of aging on catecholamine metabolism. Journal of Clinical Endocrinology and Metabolism, 60, 479–484.

    Article  PubMed  CAS  Google Scholar 

  • Hoffman, J. W., Benson, H., Arns, P. A., Stainbrook, G. L., Landsberg L., Young, J. B., & Gill, A. (1982). Reduced sympathetic nervous system responsivity associated with the relaxation response. Science, 215, 190–192.

    Article  PubMed  CAS  Google Scholar 

  • Hollister, A. S., FitzGerald, G. A., Nadeau, J. H. J., & Robertson, D. (1983). Acute reduction in human platelet α2-adrenoreceptor affinity for agonist by endogenous and exogenous catecholamines. Journal of Clinical Investigation, 72, 1498–1505.

    Article  PubMed  CAS  Google Scholar 

  • Hollister, A. S., Onrot, J., Lonce, S., Nadeau, J. H. J., & Robertson, D. (1986). Plasma catecholamine modulation of α2-adrenoreceptor agonist affinity and sensitivity in normotensive and hypertensive human platelets. Journal of Clinical Investigation, 77, 1416–1421.

    Article  PubMed  CAS  Google Scholar 

  • Hollister, A. S., Tanaka, I., Imada, T., Onrot, J., Biaggioni, I., Kincaid, D., Robertson, D., & Inagami, T. (1986). Sodium loading and posture modulate human atrial natriuretic factor plasma levels. Hypertension, 8, II106–11111.

    PubMed  CAS  Google Scholar 

  • Hui, K. K. P., & Conolly, M. E. (1981). Increased numbers of beta receptors in orthostatic hypotension due to autonomic dysfunction. New England Journal of Medicine, 304, 1473–1476.

    Article  PubMed  CAS  Google Scholar 

  • Hui, K. K. P., Wolfe, R. N., & Conolly, M. E. (1982). Lymphocyte beta-adrenergic receptors are not altered in hyperthyroidism. Clinical Pharmacology and Therapeutics, 32, 161–165.

    Article  PubMed  CAS  Google Scholar 

  • Insel, P. A., & Motulsky, H. J. (1987). Adrenergic receptors in man. New York: Raven Press.

    Google Scholar 

  • Jennings, G., Bobik, A., & Esler, M. (1981). Beta receptors in orthostatic hypotension. New England Journal of Medicine, 305, 1019.

    Article  Google Scholar 

  • Kafka, M. S., Polinsky, R. J., Williams, A., Kopin, I. J., Lake, C. R., Ebert, M. H., & Tokola, N. A. (1984). Alphaadrenergic receptors in orthostatic hypotension syndromes. Neurology, 34, 1121–1125.

    Article  PubMed  CAS  Google Scholar 

  • Karliner, J. S., Motulsky, H. J., & Insel, P. A. (1982). Apparent “down-regulation” of human platelet alpha2-adrenergic receptors is due to retained agonist. Molecular Pharmacology, 21, 36–43.

    PubMed  CAS  Google Scholar 

  • Kenakin, T. P. (1984). The classification of drugs and drug receptors in isolated tissues. Pharmacological Reviews, 36, 165–222.

    PubMed  CAS  Google Scholar 

  • Krall, J. F., Connelly, M., & Tuck, M. L. (1980). Acute regulation of beta adrenergic catecholamine sensitivity in human lymphocytes. Journal of Pharmacology and Experimental Therapeutics, 214, 554.

    PubMed  CAS  Google Scholar 

  • Kubo, T., Fukuda, K., Mikami, A., Maeda, A., Takahashi, H., Mishina, M., Haga, T., Haga, K., Ichiyama, A., Kangawa, K., Kojima, M., Matsuo, H., Hirose, T., & Numa, S. (1986). Cloning, sequencing, and expression of complementary DNA encoding the muscarinic acetylcholine receptor. Nature, 323, 411–416.

    Article  PubMed  CAS  Google Scholar 

  • Kuhar, M., & Unnerstall, J. R. (1985, February). Quantitative receptor mapping by autoradiography: Some current technical problems. Trends in Neurological Science, 49-53.

    Google Scholar 

  • Lefkowitz, R. J., & Caron, M. G. (1986). Regulation of adrenergic receptor function by phosphorylation. Journal of Molecular and Cellular Cardiology, 18, 885–895.

    Article  PubMed  CAS  Google Scholar 

  • Levitzki, A. (1984). Receptors: A quantitative approach. Menlo Park: Benjamin/Cummings.

    Google Scholar 

  • Limbird, L. E. (1986). Cell surface receptors: A short course on theory and methods. The Hague: Nijhoff.

    Book  Google Scholar 

  • Mahan, L. C., Motulsky, H. J., & Insel, P. A. (1985). Do agonists promote rapid internalization of β-adrenergic receptors?. Proceedings of the National Academy of Sciences of the United States of America, 82, 6566–6570.

    Article  PubMed  CAS  Google Scholar 

  • Mahan, L. C., McKernan, R. M., & Insel, P. A. (1987). Metabolism of alpha-and beta-adrenergic receptors in vitro and in vivo. Annual Reviews of Pharmacology and Toxicology, 27, 215–235.

    Article  CAS  Google Scholar 

  • Malbon, C. C., Graziano, M. P., & Johnson, G. L. (1984). Fat cell beta-adrenergic receptor in the hypothyroid rat: Impaired interaction with the stimulatory regulatory component of adenylate cyclase. Journal of Biological Chemistry, 259, 3254–3260

    PubMed  CAS  Google Scholar 

  • Mann, J. J., Brown, R. P., Halper, J. P., Sweeney, J. A., Kocsis, J. H., Stokes, P. E., & Bilezikian, J. P. (1985). Reduced sensitivity of lymphocyte beta-adrenergic receptors in patients with endogenous depression and psychomotor agitation. New England Journal of Medicine, 313, 715–720.

    Article  PubMed  CAS  Google Scholar 

  • Metz, A., Cowen, P. J., Gelder, M. G., Stump, K., Elliott, J. M., & Grahame-Smith, D. G. (1983). Changes in platelet alpha2-adrenoceptor binding post-partum: Possible relation to maternity blues. Lancet, 1, 495.

    Article  PubMed  CAS  Google Scholar 

  • Mohring, J., Glanzer, K., Marciel, J. A., Jr., Dusing, R., Kramer, H. J., Arogast, R., & Koch-Weser, J. (1980). Greatly enhanced pressor response to antidiuretic hormone in patients with impaired cardiovascular reflexes due to idiopathic orthostatic hypotension. Journal of Cardiovascular Pharmacology, 2, 367–376.

    Article  PubMed  CAS  Google Scholar 

  • Molinoff, P. B., Wolfe, B. B., & Weiland, G. A. (1981). Quantitative analysis of drug-receptor interactions. II. Determination of the properties of receptor subtypes. Life Sciences, 29, 427–443.

    Article  PubMed  CAS  Google Scholar 

  • Motulsky, H. J., & Insel, P. A. (1982). Adrenergic receptors in man: Direct identification, physiologic regulation, and clinical alterations. New England Journal of Medicine, 307, 18–28.

    Article  PubMed  CAS  Google Scholar 

  • Motulsky, H. J., & Mahan, L. C. (1984). The kinetics of competitive radioligand binding predicted by the law of mass action. Molecular Pharmacology, 25, 1–9.

    PubMed  CAS  Google Scholar 

  • Motulsky, H. J., O’Connor, D. J., & Insel, P. A. (1983). Platelet α2adrenergic receptors in treated and untreated essential hypertension. Clinical Science, 64, 265–272.

    PubMed  CAS  Google Scholar 

  • Motulsky, H. J., Cunningham, E. M. S., DeBlasi, A., & Insel, P. A. (1986). Agonists promote rapid desensitization and redistribution of beta adrenergic receptors on intact human mononuclear leukocytes. American Journal of Physiology, 250, E583.

    PubMed  CAS  Google Scholar 

  • Munson, P. J., & Rodbard, D. (1980). LIGAND: A versatile computerized approach for characterization of ligand-binding systems. Analytical Biochemistry, 107, 220.

    Article  PubMed  CAS  Google Scholar 

  • Nadi, N. S., Nurnberger, J. I., & Gershon, E. S. (1984). Muscarinic cholinergic receptors on skin fibroblasts in familial affective disorder. New England Journal of Medicine, 311, 225–230.

    Article  PubMed  CAS  Google Scholar 

  • Nickerson, M. (1956). Receptor occupancy and tissue response. Nature, 78, 697–698.

    Article  Google Scholar 

  • Onrot, J., Goldberg, M. R., Biaggioni, I., Wiley, R., Hollister, A. S., & Robertson, D. (1987). Oral yohimbine in human autonomic failure. Neurology, 37, 215–220.

    Article  PubMed  CAS  Google Scholar 

  • Pan, H. Y.-M., Hoffman, B. B., Pershe, R. A., & Blaschke, T. F. (1986). Decline in beta adrenergic receptor-mediated vascular relaxation with aging in man. Journal of Pharmacology and Experimental Therapeutics, 239, 802–807.

    PubMed  CAS  Google Scholar 

  • Pandey, G. N., Heinze, W. J., Brown, B. D., & Davis, J. M. (1979). Electroconvulsive shock treatment decreases beta-adrenergic receptor sensitivity in rat brain. Nature, 280, 234–235.

    Article  PubMed  CAS  Google Scholar 

  • Pfeifer, M. A., Ward, K., Malpass, T., Stratton, J., Halter, J., Evans, M., Beiter, H., Harker, L. A., & Porte, D., Jr. (1984). Variations in circulating catecholamines fail to alter human platelet alpha2-adrenergic receptor number or affinity for [3H]yohimbine or [3H]dihydroergocryptine. Journal of Clinical Investigation, 74, 1063–1072.

    Article  PubMed  CAS  Google Scholar 

  • Ratge, D., Hansel-Bessey, S., & Wisser, H. (1985). Altered plasma catecholamines and numbers ofα-and β-adrenergic receptors in platelets and leucocytes in hyperthroid patients normalized under antithyroid treatment. Acta Endocrinologica, 110, 75–82.

    PubMed  CAS  Google Scholar 

  • Reinhardt, D., Zehmisch, T., Becker, B., & Nagel-Hiemke, M. (1984). Age-dependency of alpha-and beta-adrenoceptors on thrombocytes and lymphocytes of asthmatic and nonasthmatic children. European Journal of Pediatrics, 142, 111–116.

    Article  PubMed  CAS  Google Scholar 

  • Robertson, D., Goldberg, M. R., Hollister, A. S., Wade, D., & Robertson, R. M. (1983). Clonidine raises blood pressure in idiopathic orthostatic hypotension. American Journal of Medicine, 74, 193–199.

    Article  PubMed  CAS  Google Scholar 

  • Robertson, D., Hollister, A. S., Carey, E. L., Tung, C. S., Goldberg, M. R., & Robertson, R. M. (1984). Increased vascular β2-adrenergic hypersensitivity in autonomic dysfunction. Journal of the American College of Cardiology, 3, 850–856.

    Article  PubMed  CAS  Google Scholar 

  • Robertson, D., Goldberg, M. R., Hollister, A. S., Tung, C. S., & Robertson, R. M. (1986). Use of α2 adrenoreceptor agonists and antagonists in the functional assessment of the sympathetic nervous system. Journal of Clinical Investigation, 78, 576–581.

    Article  PubMed  CAS  Google Scholar 

  • Robertson, D., Goldberg, M. R., Onrot, J., Hollister, A. S., Wiley, R., Thompson, J. G., & Robertson, R. M. (1986). Isolated failure of autonomic noradrenergic neurotransmission: Evidence for impaired β-hydroxylation of dopamine. New England Journal of Medicine, 314, 1494–1497.

    Article  PubMed  CAS  Google Scholar 

  • Shattil, S. J., McDonough, M., Turnbull, J., & Insel, P. A. (1981). Characterization of alpha-adrenergic receptors in human platelets using [3H]clonidine. Molecular Pharmacology, 19, 179–183.

    PubMed  CAS  Google Scholar 

  • Snavely, M. D., Motulsky, H. J., O’Connor, D. T., Ziegler, M. G., & Insel, P. A. (1982). Adrenergic receptors in human and experimental pheochromocytoma. Clinical and Experimental Hypertension, 4, 829–848.

    Article  CAS  Google Scholar 

  • Snyder, S. H. (1984). Cholinergic mechanisms in affective disorders. New England Journal of Medicine, 311, 254–255.

    Article  PubMed  CAS  Google Scholar 

  • Soppi, E., Varjo, P., Eskola, J., & Laitinen, L. A. (1982). Effect of strenuous physical stress on circulating lymphocyte number and function before and after training. Clinical and Laboratory Immunology, 8, 43.

    CAS  Google Scholar 

  • Sowers, J. R., Connelly-Fittinghoff, M., Tuck, M. L., & Krall, J. F. (1983). Acute changes in noradrenaline levels do not alter lymphocyte beta-adrenergic receptor concentrations in man. Cardiovascular Research, 17, 184.

    Article  PubMed  CAS  Google Scholar 

  • Stephenson, R. P. (1956). A modification of receptor theory. British Journal of Pharmacology, 11, 379–393.

    CAS  Google Scholar 

  • Stiles, G. L., Caron, M. G., & Lefkowitz, R. J. (1984). Betaadrenergic receptors: Biochemical mechanisms of physiological regulation. Physiological Reviews, 64, 661–743.

    PubMed  CAS  Google Scholar 

  • Tohmen, J. F., Cryer, P. E. (1980). Biphasic adrenergic modulation of beta-adrenergic receptors in man: Agonist-induced early increment and late decrement in beta-adrenergic receptor number. Journal of Clinical Investigation, 65, 836.

    Article  Google Scholar 

  • Van Rossum, J. M., & Ariëns, E. J. (1962). Receptor reserve and threshold phenomena. II. Theories on drug-action and a quantitative approach to spare receptors and threshold values. Archives Internationales de Pharmacodynamie, 136, 385–413.

    Google Scholar 

  • Vetulani, J., & Sulser, F. (1975). Action of various antidepressant treatments reduces reactivity of noradrenergic cyclic AMP generating system in the limbic forebrain of the rat. Nature, 257, 495–496.

    Article  PubMed  CAS  Google Scholar 

  • Villeneuve, A., Carpene, C., Berlan, M. D., & Lafontan, M. (1985). Lack of desensitization of alpha2-mediated inhibition of lipolysis in fat cells after acute and chronic treatment with clonidine. Journal of Pharmacology and Experimental Therapeutics, 233, 433–440.

    PubMed  CAS  Google Scholar 

  • Wagner, H. N., Burns, H. D., Dannals, R. F., Wong, D. F., Langstrom, B., Duelfer, T., Frost, J. J., Ravert, H. T., Links, J. M., Rosenbloom, J. B., Luckas, S. E., Kramer, A. V., & Kuhar, M. J. (1983). Imaging dopamine receptors in the human brain by positron tomography. Science, 221, 1264–1266.

    Article  PubMed  CAS  Google Scholar 

  • Weiland, G. A., & Molinoff, P. B. (1981). Quantitative analysis of drug-receptor interactions. I. Determination of kinetic and equilibrium properties. Life Sciences, 29, 313–330.

    Article  PubMed  CAS  Google Scholar 

  • Wolfe, N., Cohen, B. M., & Gelenberg, A. J. (1987). Alpha-2-adrenergic receptors in platelet membranes of depressed patients: Increased affinity for 3H-yohimbine. Psychiatric Research, 20, 107–116.

    Article  CAS  Google Scholar 

  • Wong, D. F., Wagner, H. N., Jr., Tune, L. E., Dannals, R. F., Pearlson, G. D., Links, J. M., Tamminga, C. A., Broussolle, E. P., Ravert, H. T., Wilson, A. A., Toung, J. K. T., Malat, J., Williams, J. A., O’Tuama, L. A., Snyder, S. H., Kuhar, M. J., & Gjedde, A. (1986). Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics. Science, 234, 1558–1562.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, 37232, USA

    David Robertson, Yelena Parfyonova, Mikhail Menshikov & Alan S. Hollister

  2. Myasnikov Institute of the All-Union Cardiological Research Center, Moscow, USSR

    Yelena Parfyonova & Mikhail Menshikov

Authors
  1. David Robertson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yelena Parfyonova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mikhail Menshikov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Alan S. Hollister
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Miami, Coral Gables, Florida, USA

    Neil Schneiderman

  2. National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA

    Stephen M. Weiss  & Peter G. Kaufmann  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer Science+Business Media New York

About this chapter

Cite this chapter

Robertson, D., Parfyonova, Y., Menshikov, M., Hollister, A.S. (1989). Receptors. In: Schneiderman, N., Weiss, S.M., Kaufmann, P.G. (eds) Handbook of Research Methods in Cardiovascular Behavioral Medicine. The Springer Series in Behavioral Psychophysiology and Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0906-0_14

Download citation

  • DOI: https://doi.org/10.1007/978-1-4899-0906-0_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0908-4

  • Online ISBN: 978-1-4899-0906-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation