Regulation of Expression of HIV-1 by Viral Factors

  • George N. Pavlakis
  • Barbara K. Felber
  • Connie M. Wright
  • Christos Cladaras
  • Margarita Hadzopouloucladaras
  • Angelos Athanassopoulos
Conference paper

Abstract

The expression of the human immunodeficiency virus type 1 (HIV-1) in human cells is regulated by viral factors. This regulation results in the establishment of a steady-state permitting the balanced expression of the viral components. The concerted function of two viral activator proteins tat and rev is necessary for viral expression. Tat and rev are expressed from overlapping reading frames (Figure 1). The action of tat is mediated by a cis-acting element in the R region of the LTR (TAR), while the action of rev is mediated by a cis-acting element in the env region (RRE) (Figure 1). Tat is essential for the accumulation of all viral mRNAS. On the other hand, rev is essential for the accumulation of those viral mRNAs encoding structural proteins.

Keywords

Human Immunodeficiency Virus Indicator Cell Line Cell Lymphotropic Virus Type Unspliced Viral mRNA Proviral Mutant 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • George N. Pavlakis
    • 1
  • Barbara K. Felber
    • 1
  • Connie M. Wright
    • 1
  • Christos Cladaras
    • 1
  • Margarita Hadzopouloucladaras
    • 1
  • Angelos Athanassopoulos
    • 1
  1. 1.BRI-Basic Research ProgramNCI-Frederick Cancer Research FacilityFrederickUSA

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