Laboratory Tests for Human T-Lymphotropic Virus Type I

  • Dana Gallo
Conference paper

Abstract

In 1978, the first human retrovirus was isolated from the lymphocytes of a patient in the United States with a mature T-cell malignancy (Poiesz et al. 1980). This virus is now known as human T-lymphotropic virus type I (HTLV-I). In 1980, serologic tests revealed that almost 100% of sera collected from patients with adult T-cell leukemia (ATL) in Japan were positive for HTLV-I antibody (Kalyanaraman et al. 1982a; Robert-Guroff et al. 1982). Subsequently, other areas endemic for HTLV-I infection were found, including the Caribbean Islands (Catovsky et al. 1982; Gallo et al. 1983a), the southeastern United States (Blayney et al. 1983), parts of South America (Gallo et al. 1983a; Robert-Guroff, 1984), parts of southern Italy (Manzari et al. 1984) and many locations in Africa (Hunsmann et al. 1983); Saxinger et al. 1984). HTLV-I infection in theses areas is associated with 50–70% of all lymphoid leukemias of adulthood.

Keywords

Hairy Cell Leukemia Particle Agglutination Tropical Spastic Paraparesis Particulate Staining Kalyanaraman Versus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Dana Gallo
    • 1
  1. 1.Division of Laboratories, Viral and Rickettsial Disease LaboratoryCalifornia Department of Health ServiceBerkeleyUSA

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