Antiviral Cytotoxic T-Lymphocytes and Vaccines

  • Stephen Martin
  • Barry T. Rouse
Conference paper


A characteristic of antigen recognition by T lymphocytes is restriction by the gene products of the major histocompatibility complex (MHC) (Benacerraf, 1981; Zinkernagel and Doherty, 1979). Until 1983, class I MHC molecules (H-2K, D, and L in the mouse and HLA-A, B, and C in man) were considered as the sole restriction elements for virus-specific cytotoxic T lymphocytes (CTL) (Biddison, 1982; McMichael, 1980), but recently class II MHC molecules (Ia in the mouse and HLA-D and DR in man) were shown to restrict the recognition of antigen by some antiviral CTL (Jacobson and Biddison, 1986). The significance of class II MHC restricted CTL, however, remains unknown and, with the exception of measles virus (Jacobson et al. 1984, 1985), the majority of antiviral CTL appears to be restricted by class I MHC gene products. Therefore, our comments in this review will concentrate on class I MHC restricted CTL and, in addition, will emphasize responses against herpes simplex virus type 1 (HSV-1).


Major Histocompatibility Complex Major Histocompatibility Complex Molecule Major Histocompatibility Complex Gene Product 
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Stephen Martin
    • 1
  • Barry T. Rouse
    • 1
  1. 1.Department of Microbiology, College of Veterinary MedicineUniversity of TennesseeKnoxvilleUSA

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