Adenovirus Gene Products that Affect Host Immune Mechanisms

  • Phyllis R. Flomenberg
  • Marshall S. Horwitz
Conference paper


The clinical and pathological manifestations of viral diseases are the net result of virus destruction or transformation of cells and the host immune responses to these infections. The role of specific cell-mediated and humoral immune responses, as well as nonspecific immune responses, in viral pathogenesis is not well understood (Sissons and Oldstone, 1985). Viruses present unique challenges to the immune system because all are intracellular pathogens; some directly infect cells of the immune system and some can establish persistent and/or latent infections. Viral infections may be unusually severe or persistent in immunocompromised hosts, especially those with T cell defects. In contrast, in the attempt to eradicate virus, the normal immune response in itself may cause pathology.


Major Histocompatibility Complex Adenovirus Type Chicken Embryo Lethal Orphan Adenovirus Gene Product 
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Phyllis R. Flomenberg
    • 1
  • Marshall S. Horwitz
    • 2
  1. 1.Department of MedicineVeterans Administration Medical CenterNew YorkUSA
  2. 2.Departments of Microbiology-Immunology, Cell Biology and PediatricsAlbert Einstein College of MedicineBronxUSA

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