Skip to main content
SpringerLink
Log in

Adenovirus Gene Products that Affect Host Immune Mechanisms

  • Conference paper
Medical Virology 8

  • 34 Accesses

Abstract

The clinical and pathological manifestations of viral diseases are the net result of virus destruction or transformation of cells and the host immune responses to these infections. The role of specific cell-mediated and humoral immune responses, as well as nonspecific immune responses, in viral pathogenesis is not well understood (Sissons and Oldstone, 1985). Viruses present unique challenges to the immune system because all are intracellular pathogens; some directly infect cells of the immune system and some can establish persistent and/or latent infections. Viral infections may be unusually severe or persistent in immunocompromised hosts, especially those with T cell defects. In contrast, in the attempt to eradicate virus, the normal immune response in itself may cause pathology.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Anderson KP, Fennie EH (1987) Adenovirus early region lA modulation of interferon antiviral activity. J Virol 61: 787–795.

    PubMed  CAS  Google Scholar 

  • Anderson M, Paabo S, Nilsson T, Peterson PA (1985) Impaired intracellular transport of class I MHC antigens as a possible means for adenovirus to evade immune surveillance. Cell 43: 215–222.

    Google Scholar 

  • Bellgrau D, Walker TA, Cook JL (1988) Recognition of adenovirus E1A gene products on immortalized cell surfaces by cytotoxic T lymphocytes. J Virol 62: 1513–1519.

    PubMed  CAS  Google Scholar 

  • Berkner KL, Sharp PA (1982) Preparation of adenovirus recombinants using plasmids of viral DNA. In: Gluzman Y (ed) Eukaryotic Viral Vectors. Cold Spring Harbor, New York. pp 193.

    Google Scholar 

  • Beutler B, Cerami A (1987) Cachectin: more than a tumor necrosis factor. N Engl J Med 316: 379–385.

    PubMed  CAS  Google Scholar 

  • Bhat BM and Wold WSM (1987) A small deletion distant from a splice or polyadenylation site dramatically alters pre-mRNA processing in region E3 of adenovirus. J Virol 61: 3938–3945.

    PubMed  CAS  Google Scholar 

  • Bjorkman PJ, Saper MA, Sanraoui B, Bennett WS, Strominger JL, Wiley DC (1987a) Structure of the human class I histocompatibility antigen, HLA-A2. Nature 329: 506–512.

    PubMed  CAS  Google Scholar 

  • Bjorkman PJ, Saper MA, Sanraoui B, Bennett WS, Strominger JL, Wiley DC (1987b) The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens. Nature 329: 512–518.

    PubMed  CAS  Google Scholar 

  • Bougneres TF, Carel JC, Castano L, Coitard C, Garden SP, Landais P, Hors J, Mihatsch NS, Paillard M, Chauusain JL, Bach JF (1988) Factors associated with early remission of Type I diabetes in children treated with cyclosporine. N Eng J Med 318: 663–670.

    CAS  Google Scholar 

  • Brandt CD, Kim HW, Vargosdo AJ, Jeffries BC, Arrobio JO, Rindge B, Parrott RH, Chanock RM (1969) Infections in 18,000 infants and children in a controlled study of respiratory tract disease. I. Adenovirus pathogenicity in relation to serologic type and illness syndrome. Am J Epidemiol 90: 484–500.

    Google Scholar 

  • Brinton NA, Blank KJ, Nathanson N (1984) Host genes that influence susceptibility to viral diseases. In: Notkins AL, Oldstone MBA (eds) Concepts of Viral Pathogenesis. Springer Verlag, New York. pp 71–85.

    Google Scholar 

  • Buchmeier MJ, Welsh RM, Dutko FS, Oldstone MBA (1980) The virology and immunobiology of lymphocytic choriomeningitis virus infection. Adv Immunol 30: 275–332.

    PubMed  CAS  Google Scholar 

  • Burgert H, Kvist S (1985) An adenovirus type 2 glycoprotein blocks cell surface expression of human histocompatibility class I antigens. Cell 41: 987–997.

    PubMed  CAS  Google Scholar 

  • Burgert H, Kvist S (1987) The E3/19K protein of adenovirus type 2 binds to the domains of histocompatibility antigens required for CTL recognition. EMBO 6: 2019–2026.

    CAS  Google Scholar 

  • Campbell AE, Foley FL, Tevethia SS (1983) Demonstration of multiple antigenic sites of the SV40 transplantation rejection antigen by using cytotoxic T lymphocytic clones. J Immunol 130: 490–496.

    PubMed  CAS  Google Scholar 

  • Carlin CR, Tollefson AE, Brady HA, Hoffman BL, Wold WSM (1989) Epidermal growth factor receptor is down-regulated by a 10,4000 MW protein encoded by the E3 region of adenovirus. Cell 57: 135–144.

    PubMed  CAS  Google Scholar 

  • Casali P, Rice GPA and Oldstone MBA (1984) Viruses disrupt functions of human lymphocytes. J Exp Med 159: 1322–1337.

    PubMed  CAS  Google Scholar 

  • Chang C, Lepine P, Lelong M, Le-Tan-Vinn, Statge P, Virat J (1958) Severe and fatal pneumonia in infants and young children associated with adenovirus infection. Am J Hygiene 67: 367–378.

    Google Scholar 

  • Chardonnet Y, Dales S (1970) Early events in the interaction of adenovirus with Hela cells. I. Penetration of type 5 and intracellular release of the DNA genome. Virology 40: 462–477.

    PubMed  CAS  Google Scholar 

  • Chatterjee D, Maizel JV Jr. (1984) Homology of adenoviral E3 glycoprotein with HLA-DR heavy chain. Proc Natl Acad Sci USA 81: 6039–6043.

    PubMed  CAS  Google Scholar 

  • Cladaras C and Wold WSM (1985) DNA sequence of the early E3 transcription unit of adenovirus 5. Virology 140: 28–43.

    PubMed  CAS  Google Scholar 

  • Cook J, May B, Chen MJ, Shalloway D, Walker T (1988) E1A gene expression in transformed cells induces cytolytic susceptibility by TNF-dependent and independent mechanisms. Abstract presented at the Tumor Virus Meeting on SV40, polyoma, and adenoviruses. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York. p 246.

    Google Scholar 

  • Creasy AA, Doyle LV, Reynonds MT, Jung T, Lin LS, Vitt CR (1987) Biological effects of recombinant tumor necrosis factor and its novel muteins on tumor and normal cell lines. Can Res 47: 145–149.

    Google Scholar 

  • Cutt JR, Shenk T, Hearing P (1987) Analysis of adenovirus early region 4 encoded polypeptides synthesized in productively infected cells. J Virol 61: 543–552.

    PubMed  CAS  Google Scholar 

  • Dales S, Chardonnet Y (1973) Early events in the interaction of adenovirus with HeLa cells. IV. Association with microtubules and the nuclear core complex during vectorial movement in the inoculum. Virology 56: 465–483.

    Google Scholar 

  • deJong J, Wigand R, Kidd AH, Wadell G, Kapsenberg JG, Muzerie CJ, Wermenbol AG, Fritzlaff RG (1983) Candidate adenoviruses 40 and 41: Fastidious adenoviruses from human infant stool. J Med Virol I I: 215–231.

    Google Scholar 

  • deJong PJ, Valderrama G, Spigland I, Horwitz MS (1983) Adenovirus isolates from the urines of patients with the acquired immunodeficiency syndrome. Lancet 1: 1293–1295.

    CAS  Google Scholar 

  • Doherty PC, Zinkernagel RM (1975) H-2 compatibility is required for T-cell mediated lysis of target cell infected with lymphocytic choriomengitis virus. J Exp Med 141: 502–507.

    PubMed  CAS  Google Scholar 

  • Fitzgerald DJP, Padmanabhan R, Pastan I, Willingham MC (1983) Adenovirus-induced release of epidermal growth factor and Pseudomonas toxin into the cytosol of KB cells during receptor-mediated endocytosis. Cell 32: 607–617.

    PubMed  CAS  Google Scholar 

  • Flomenberg PR, Chen M, Munk G, Horwitz MS (1987a) Molecular epidemiology of adenovirus type 35 infections in immunocompromised hosts. J Infect Dis 155: 1127–1134.

    PubMed  CAS  Google Scholar 

  • Flomenberg PR, Chen M, Horwitz MS (1987b) Characterization of a major histocompatibility complex class I antigen-binding glycoprotein from adenovirus type 35, a type associated with immunocompromised hosts. J Virol 61: 3665–3671.

    PubMed  CAS  Google Scholar 

  • Flomenberg PR, Chen M, Horwitz MS (1988) Sequence and genetic organiza- tion of adenovirus type 35 early region 3. J Virol 62: 4431–4437.

    PubMed  CAS  Google Scholar 

  • Fohring B, Gallimore PH, Mellow GH, Raska K Jr (1983) Adenovirus type 12 specific cell surface antigen in transformed cells is a product of the Elb early region. Virology 13: 463–472.

    Google Scholar 

  • Fox JP, Hall CE, Cooney MK (1977) The Seattle Virus Watch. VII. Ob-servations of adenovirus infections. Am J Epidemiol 105: 362–386.

    Google Scholar 

  • Germain RN (1988) Antigen processing and CD4+ T cell depletion in AIDS. Cell 54: 441–444.

    PubMed  CAS  Google Scholar 

  • Ginsberg HS, Bello LJ, Levine AJ (1967) Control of biosynthesis of host macromolecules in cells infected with adenovirus. In: Colter JS, Paranchych W (eds.) The Molecular Biology of Viruses. Academic Press. New York. pp 547–572.

    Google Scholar 

  • Ginsberg HS, Valdesuso J, Horswood R, Chanock RM and Prince G (1987) Adenovirus gene products affecting pathogenesis. In: Chanock R, Lerner RA, Brown F, Ginsberg HS (eds.) Vaccines 87. Cold Spring Harbor Laboratory. Cold Spring Harbor. New York. pp 322–326.

    Google Scholar 

  • Gooding LR, Elmore LW, Tollefson AE, Brady HA, Wold WSM (1988) A 14,700 MW protein from the E3 region of adenovirus inhibit cytolysis by tumor necrosis factor. Cell 53: 341–346.

    PubMed  CAS  Google Scholar 

  • Graham FL, Abrahams PS, Moulder C, Heijneker HL, Warnaar SO, deVries FAJ, Fiers W, van der Eb AJ (1975) Studies on in vitro transformation by DNA and DNA fragments of human adenoviruses and simian virus 40. Cold Spring Harbor Symp Quant Biol 39: 673.

    Google Scholar 

  • Halstead SB, O’Rourke EF (1977) Dengue virus and mononuclear phagocytes: I. Infection enhancement by non-neutralizing antibodies. J Exp Med 146: 201.

    Google Scholar 

  • Hartley JW, Heubner RJ, Rowe WP (1956) Serial propagation of adenovirus ( APC) in monkey kidney tissue cultures. Proc Soc Exp Biol Med 92: 667.

    Google Scholar 

  • Hartley JW and Rowe WP (1960) A new mouse virus apparently related to the adenovirus group. Virology 11: 645.

    PubMed  CAS  Google Scholar 

  • Hennache B, Boulanger P (1977) Biochemical study of KB cell receptor for adenovirus. Biochem J 166: 237–247.

    PubMed  CAS  Google Scholar 

  • Herisse J, Courtois G, Galibert F (1980) Nucleotide sequence of the EcoRI D fragment of adenovirus 2 genome. Nucl Acids Res 8: 2173–2192.

    PubMed  CAS  Google Scholar 

  • Herisse J, Galibert F (1981) Nucleotide sequence of EcoRI E fragment of adenovirus 2 genome. Nucl Acids Res 9: 1229–1240.

    CAS  Google Scholar 

  • Ho DD, Promeranz RJ, Kaplan JC (1987) Pathogenesis of infection with human immunodeficiency virus. N Engl J Med 317: 278–286.

    PubMed  CAS  Google Scholar 

  • Hong JS, Mullis KG, Engler JA (1988) Characterization of the early region 3 and fiber genes of Adz (in press).

    Google Scholar 

  • Horvath JL, Palkonyay L, Weber J (1986) Group C adenovirus DNA sequences in human lymphoid cells. J Virol 59: 189–192.

    PubMed  CAS  Google Scholar 

  • Horwitz MS (1971) Intermediates in replication of type 2 adenovirus. Virology 8: 675–683.

    CAS  Google Scholar 

  • Horwitz MS (1985a) Adenoviral diseases. In: Fields BN (ed.) Virology. Raven Press. New York. pp 477–495.

    Google Scholar 

  • Horwitz MS (1985b) Adenoviruses and their replication. In: Fields BN (ed.) Virology. Raven Press. pp 433–476.

    Google Scholar 

  • Horwitz MS (1989) Adenoviruses and their replication. In: Fields BN (ed.) Virology (in press, volume 2).

    Google Scholar 

  • Horwitz MS, Valderrama G, Korn R, Spigland I (1984) Adenovirus isolated from the urines of AIDS patients: characterization of group B recombinants. In: Gottlieb MS and Groopman JE (eds.) Acquired Immune Deficiency Syndrome. Alan R Liss Inc. New York. pp 187–207.

    Google Scholar 

  • Huebner RJ, Rowe WP, Lane WT (1962) Oncogenic effects in hamsters of human adenovirus types 12 and 18. Proc Natl Acad Sci USA 48: 2051.

    PubMed  CAS  Google Scholar 

  • Ishibashi M, Yasue H (1984) Adenoviruses of animals. In: Ginsberg HS (ed.) The Adenoviruses. Plenum Press. New York. pp 497–562.

    Google Scholar 

  • Kast WM, Bronkhorst, deWaal LP, Melief CJM (1986) Cooperation between cytotoxic and helper T lymphocytes in protection against lethal Sendai virus infection. J Exp Med 164: 723–738.

    PubMed  CAS  Google Scholar 

  • Kelly TJ, Lewis AM Jr. (1973) Use of non-defective adenovirus simian virus 40 hybrids for mapping the simian virus 40 genome. J Virol 12: 643–652.

    PubMed  Google Scholar 

  • Kelsey DS (1978) Adenovirus meningoencephalitis. Pediatrics 61: 291–293.

    PubMed  CAS  Google Scholar 

  • Kemp MC, Hierholzer JC, Cabradilla CP, Obijesti JF (1983) The changing etiology of epidemic keratoconjunctivitis: Antigenic and restriction enzyme analysis of adenovirus types 19 and 37 isolated over a 10 year period. J Infect Dis 148: 29–33.

    Google Scholar 

  • Kitajewski J, Schneider RJ, Safter B, Munemitsie SM, Samuel CE, Thimmappaya B and Shenk T (1985) Adenovirus VA1 RNA antagonizes the antiviral action of interferon by preventing activation of the interferon-induced elF-2a kinase. 45: 195–200.

    Google Scholar 

  • Koneru B, Jaffe R, Esquivel CO, Junz R, Tode S, Iwatsaki S, Starzl TE (1987) Adenoviral infections in pediatric liver transplant recipients. JAMA 258: 489–492.

    PubMed  CAS  Google Scholar 

  • Kvist S, Ostberg L, Persson H, Philipson L (1978) Molecular association between transplantation antigens and a cell surface antigen in an adenovirus-transformed cell line. Proc Natl Acad Sci USA 75: 56745678

    Google Scholar 

  • Landry ML, Long CKY, Neddermann K, Solomon L, Hsiung GD (1987) Disseminated adenovirus infection in an immunocompromised host. Pitfalls in diagnosis. Am J Med 83: 555–559.

    Google Scholar 

  • Larsen SH, Margolskee RF, Nathans D (1979) Alignment of the restriction map of mouse adenovirus FL with that of human adenovirus 2. Virology 97: 406.

    PubMed  CAS  Google Scholar 

  • Lavery D, Lu SM, Lufka T, Chen-Kiang S (1987) Productive infection of cultured human lymphoid cells by adenovirus. J Virol 61: 1466–1472.

    PubMed  CAS  Google Scholar 

  • Lewis AM Jr., Baum SG, Prigge KO, Rowe WP (1966) Occurrence of adenovirus SV40 hybrids among monkey kidney cell adapted strains of adenovirus. Proc Soc Exp Biol Med 122: 214–218.

    PubMed  Google Scholar 

  • Lewis JB, Mathews M (1980) Control of adenovirus early gene expression: A class of immediate early products. Cell 21: 303–313.

    Google Scholar 

  • Lichy JH, Field J, Horwitz MS, Hurwitz J (1982) Separation of the adenovirus terminal protein precursor from its associated DNA polymerase: Role of both proteins in the initiation of adenovirus DNA replication. Proc Natl Acad Sci USA 79: 5225–5229.

    Google Scholar 

  • Lichy JH, Enomoto T, Field J, Friefeld BR, Guggenheimer RA, Ikeda J, Nagata K, Horwitz MS, Hurwitz J (1983) Isolation of proteins involved in the replication of adenovirus DNA in vitro. Cold Spring Harbor Symp Quanti Biol. 47: 731–740.

    Google Scholar 

  • Lin YL, Askonas BA (1981) Biological properties of an influenza A virus specific killer T cell clone. J Exper Med 154: 225–234.

    CAS  Google Scholar 

  • Mandel B (1982) Interaction of viruses with neutralizing antibodies. In Frankel-Conrat H, Wagner RR (eds.) Comprehensive Virology. Plenum Press. New York. pp 37–121.

    Google Scholar 

  • Martin DB, Weiner LB, Nieburg PJ, Blair DC (1979) Atypical measles in adolescents and young adults. Ann Intern Med 90: 877–881.

    PubMed  CAS  Google Scholar 

  • Moran E, Mathew MB (1987) Multiple functional domains in the adenovirus E1A gene. Cell 48: 177–178.

    PubMed  CAS  Google Scholar 

  • Morin JE, Lubeck MD, Barton JE, Conley AJ, Davis AR, Hung PP (1987) Recombinant adenovirus induces antibody response to hepatitis B virus surface antigen in hamsters. Proc Natl Acad Sci USA 84: 4626.

    PubMed  CAS  Google Scholar 

  • Mufson MA, Belshe RB, Horrigen TJ, Zollar LM (1973) Cause of acute hemor-rhagic cystitis in children. Am J Dis Child 126: 605–609.

    PubMed  CAS  Google Scholar 

  • Nader P, Horwitz MS, Rousseau P (1968) Atypical exanthem after exposure to measles in vaccinated children. J Ped 72: 22.

    Google Scholar 

  • Nairn R, Yamaga K, Nathenson SG (1980) Biochemistry of gene products from murine MHC mutants. Ann Rev Genet 14: 241–277.

    PubMed  CAS  Google Scholar 

  • Nash AA (1984) Viruses as regulators of delayed hypersensitivity T-cell and supressor T-cell function. In: Notkins AL and Oldstone MBA (eds.) Concepts in Viral Pathogenesis. Springer Verlag. New York. pp 225.

    Google Scholar 

  • Nevins JR (1982) Induction of the synthesis of a 70,000 dalton mammalian heat shock protein by the adenovirus E1A gene product. Cell 29: 913919

    Google Scholar 

  • Numazaki Y, Kumasaka T, Yano N, Yamanaka M, Miyazawa T, Tikai S, Ishida N (1973) Further study of acute hemorrhagic cystitis due to adenovirus type II. N Engl J Med 289: 344–347.

    PubMed  CAS  Google Scholar 

  • Old L (1985) Tumor necrosis factor (TNF). Science 230: 630–632.

    PubMed  CAS  Google Scholar 

  • Oldstone MBA, Dixon FJ (1970) Pathogenesis of chronic disease associated with persistent lymphocytic choriomeningitis viral infection. J Exp Med 131: 1–14.

    PubMed  CAS  Google Scholar 

  • Paabo S, Bhat BM, Wold WSM, Peterson PA (1986) Adenoviruses of subgenera B,C,D and E modulate cell-surface expression of major histocompatibility complex class I antigens. Proc Natl Acad Sci USA 83: 9665–9669.

    CAS  Google Scholar 

  • Paabo S, Bhat BM, Wold WSM, Peterson PA (1987) A short sequence in the COOH-terminus makes an adenovirus membrane glycoprotein a resident of the endoplasmic reticulum. Cell 50: 311.

    PubMed  CAS  Google Scholar 

  • Pacini DL, Duvobi EJ, Clyde WA, Jr. (1984) A new animal model for human respiratory tract disease due to adenovirus. J Infect Dis 150: 92–97.

    PubMed  CAS  Google Scholar 

  • Pastan I, Seth P, Fitzgerald D, Willingham M (1987) Adenovirus entry into cells. Some new observations on an old problem. In: Notkins AL and Oldstone MBA (eds.) Concepts in Viral Pathogenesis. Springer Verlag. New York. pp 141–156.

    Google Scholar 

  • Persson H, Kvist S, Ostberg L, Petersson PA, Philipson L (1979) Adenovirus early glycoprotein E3–19K and its association with transplantation antigens. Cold Spring Harbor Symp Quant Biol 44: 509517.

    Google Scholar 

  • Persson H, Philipson L (1982) Regulation of adenovirus gene expression. Curr Top Microbiol Immunol 97: 157–203.

    PubMed  CAS  Google Scholar 

  • Philipson L, Lonberg-Mola K, Petterson U (1968) Virus receptor interaction in an adenovirus system. J Virol 2: 1064–1075.

    PubMed  CAS  Google Scholar 

  • Ralston R, Bishop JM (1983) The protein products of the myc and myb oncogenes and adenovirus Ela are structurally related. Nature (London) 306: 803–806.

    CAS  Google Scholar 

  • Rowe WP, Huebner RJ, Gillmore LK, Parrott RH, Ward TGH (1953) Isolation of a cytopathogenic agent from human adenoids undergoing spontaneous degeneration in tissue culture. Proc Soc Exp Biol Med 84: 570.

    PubMed  CAS  Google Scholar 

  • Rowe WP, Baum SG (1965) Studies of adenovirus SV40 hybrid viruses. II. Defectiveness of the hybrid particles. J Exp Med 122: 955–966.

    Google Scholar 

  • Rubinstein P, Walker ME, Fedur B, Witt ME, Cooper LV, Ginsberg-Fellsner S (1982) HLA system in congenital rubella patients with and without diabetes. Diabetes 31: 1088–1091.

    PubMed  CAS  Google Scholar 

  • Ruley H (1983) Adenovirus early region lA enables viral and cellular transforming genes to transform primary cells in culture. Nature 304: 602.

    PubMed  CAS  Google Scholar 

  • Schrier PI, Bernards R, Vaessen RTMJ, Houweling A, van der EH AJ (1983) Expression of class I major histocompatibility antigens switched off by highly oncogenic adenovirus 12 in transformed rat cells. Nature 305: 771–775.

    PubMed  CAS  Google Scholar 

  • Seth P, Fitzgerald D, Ginsberg H, Williamham M, Pastan I (1984) Evidence that the penton base of adenovirus is involved in potentiation of toxicity of Pseudomonas exotoxin conjugated to epidermal growth factor. Molec Cell Biol 4: 1428–1533.

    Google Scholar 

  • Severinsson L, Martens I, Peterson PA (1986) Differential association between two human MHC class I antigens and an adenoviral glycoprotein. J Immunol 137: 1003–1009.

    PubMed  CAS  Google Scholar 

  • Shemer-Avni Y, Wallach D, Sarov I (1988) Inhibition of Chlamydia trachomatis growth by recombinant tumor necrosis factor. Infect Immun 56: 2503–2506.

    PubMed  CAS  Google Scholar 

  • Shields AF, Hackman RC, Fife KH, Corey L, Meyers JD (1985) Adenovirus infections in patients undergoing bone-marrow transplantation. N Engl J Med 315: 529–533.

    Google Scholar 

  • Signas C, Katze MG, Persson H, Philipson L (1982) An adenovirus glycoprotein binds heavy chains of class I transplantation antigens from man and mouse. Nature 299: 175–177.

    PubMed  CAS  Google Scholar 

  • Signas C, Akusjarvi G, Pettersson U (1986) Region E3 of human adenoviruses; differences between the oncogenic adenovirus 3 and the nononcogenic adenovirus 2. Gene 50: 173–184.

    PubMed  CAS  Google Scholar 

  • Siliciano RF, Lawton T, Knall C, Karr RW, Berman P, Gregory T, Reinherz EL (1988) Analysis of host-virus interactions in AIDS with anti-gp120 T cell clones: Effects of HIV sequence variation and a mechanism for CD4+ cell depletion. Cell 54: 561–575.

    PubMed  CAS  Google Scholar 

  • Similia SO, Ylikorkala O, Wasz-Huckert O (1971) Type 7 adenovirus pneumonia. J Pediatr 79: 605–611.

    Google Scholar 

  • Sissons JGP, Oldstone MBA (1985) Host responses to viral infections. In: Fields BN (ed.) Virology. Raven Press. New York. pp 265–279.

    Google Scholar 

  • Stadler H, Hierholzer JC, Oxman MN (1977) New human adenovirus (candidate adenovirus type 35) causing fatal disseminated infection in a renal transplant recipient. J Clin Microbiol 6: 257–265.

    Google Scholar 

  • Svensson U, Persson H, Everitt E (1981) Virus-receptor interaction in the adenovirus system. I. Identification of virion attachment proteins of the HeLa cell plasma membrane. J Virol 38: 70–81.

    Google Scholar 

  • Tanaka K, Isselbacher KJ, Khoury G, Jay G (1985) Reversal of oncogenesis by the expression of a major histocompatibility complex class I gene. Science 228: 26–30.

    PubMed  CAS  Google Scholar 

  • Top FH, Jr, Buescher EL, Bancroft WH, Russell PK (1971) Immunization with live types 7 and 4 adenovirus vaccines. II. Antibody response and protective effect against acute respiratory disease due to adenovirus type 7. J Infect Dis 124: 155–160.

    PubMed  Google Scholar 

  • Townsend ARM, McMichael AJ, Carter NP, Huddleston JA, Brownlee GG (1984) Cytotoxic T cell recognition of the influenza nucleoprotein and hemagglutin expresses in transfected mouse L cells. Cell 39: 13–25.

    PubMed  CAS  Google Scholar 

  • Vaessen RTMJ, Houweling A, van der Eb AJ (1987) Post-transcriptional control of class I MHC mRNA expression in adenovirus 12 transformed cells. Science 235: 1486–1488.

    PubMed  CAS  Google Scholar 

  • Van der Veen J, Mess A (1973) Serological classification of two mouse adenoviruses. Arch Gesamte Virusforsch 42: 235.

    PubMed  Google Scholar 

  • Vasavada R, Eager KB, Barbanti-Brodano G, Caputo A, Ricciardi RP (1986) Adenovirus type 12 early region lA proteins repress class I HLA expression in transformed human cells. Proc Natl Acad Sci USA 83: 5257–5261.

    PubMed  CAS  Google Scholar 

  • Wadell G (1984) Molecular epidemiology of human adenoviruses In: W. Doerfler (ed.) Current Topics in Microbiology and Immunology. Vol 110. Springer-Verlag. Berlin. pp 191–220.

    Google Scholar 

  • Whyte P, Buchkovci KJ, Horowitz JM, Friend SH, Raybuck M, Weinberg R, Harlow E (1988) Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product. Nature 34: 124–128.

    Google Scholar 

  • Wigand R, Butha A, Dreizin RS, Esche H, Ginsberg HS, Green M, Hierholzer JC, Kalter SS, McTerran JB, Petterson U, Russell WC, Wadell G (1982) Adenoviridae. Second report. Intervirology 18: 169–176.

    Google Scholar 

  • Wold WSM, Cladaras C, Magie SC, Yacoub N (1984) Mapping a new gene that encodes an 11,600 molecular weight protein in the E3 transcription unit of adenovirus 2. J Virol 52: 307–313.

    PubMed  CAS  Google Scholar 

  • Wong GHW, Goeddel DV (1986) Tumour necrosis factors alpha and beta inhibit virus replication and synergize with interferon. Nature 323: 819–822.

    PubMed  CAS  Google Scholar 

  • Yoon JW, Austin M, Onodera T, Notkins AL (1979) Virus-induced diabetes mellitus: isolation of a virus from the pancreas of a child with diabetes ketoacidosis. N Engl J Med 300: 1173–1179.

    PubMed  CAS  Google Scholar 

  • Zahradnik JM, Spencer MJ, Porter DD (1980) Adenovirus infection in the immunocompromised patient. Am J Med 68: 725–732.

    PubMed  CAS  Google Scholar 

  • Zinkernagel RM, Althage A (1977) Antiviral protection by virus-immune cytotoxic T lymphocytes infected target cells are lysed before infectious virus progeny is assembled. J Exp Med 145: 644–651.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medicine, Veterans Administration Medical Center, 1st Avenue at E. 24th Street, New York, NY, USA

    Phyllis R. Flomenberg

  2. Departments of Microbiology-Immunology, Cell Biology and Pediatrics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York, USA

    Marshall S. Horwitz

Authors
  1. Phyllis R. Flomenberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Marshall S. Horwitz
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Irvine Medical Center, University of California, Orange, California, USA

    Luis M. de la Maza  & Ellena M. Peterson  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer Science+Business Media New York

About this paper

Cite this paper

Flomenberg, P.R., Horwitz, M.S. (1989). Adenovirus Gene Products that Affect Host Immune Mechanisms. In: de la Maza, L.M., Peterson, E.M. (eds) Medical Virology 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0891-9_11

Download citation

  • DOI: https://doi.org/10.1007/978-1-4899-0891-9_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0893-3

  • Online ISBN: 978-1-4899-0891-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation