Mechanism(S) of Coxsackievirus-Induced Acute Myocarditis in the Mouse

  • Charles J. Gauntt
  • Elmer K. Godeny
  • C. William Lutton
  • Helen M. Arizpe
  • Nora M. Crapman
  • Steven M. Tracy
  • George E. Revtyak
  • Anthony J. Valente
  • Marius M. Rozek


Acute myocarditis can be induced in several murine strains following inoculation of infant or adolescent mice with a coxsackievirus group B (CVB) (Gauntt, 1987; Herskowitz et al. 1986; Lerner and Reyes, 1985; McManus et al. 1987; Woooruff, 1980). Murine-CVB models have provided significant insight into several mechanisms responsible for this disease process and are particularly attractive because of the pathologic similarities between the induced cardiac lesions and those found in heart tissue from cases of human myocarditis (Lerner and Reyes, 1985; McManus et al. 1987). The CVB have been isolated rarely from heart tissues of these patients. Considerable serologic evidence suggests that serotypes Bl-B5 are the major etiologic agents responsible for about half of the clinical cases of myocarditis (Gear and Measroch, 1973; Grist and Bell, 1974; Grist et al. 1978; Lansdown, 1978; Smith, 1970) and coxsackievirus B3 (CVB3) is the serotype most frequently associated with myocardial disease (Lerner and Wilson, 1973).


Heart Tissue High Performance Liquid Chromatogra High Performance Liquid Chromatogra CVB3 Infection Murine Myocarditis 
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Charles J. Gauntt
    • 1
  • Elmer K. Godeny
    • 1
  • C. William Lutton
    • 1
  • Helen M. Arizpe
    • 1
  • Nora M. Crapman
    • 1
  • Steven M. Tracy
    • 1
  • George E. Revtyak
    • 1
  • Anthony J. Valente
    • 1
  • Marius M. Rozek
    • 1
  1. 1.The University of Texas Health Science Center of San AntonioSan AntonioUSA

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