Autism: Immunological Investigations
- 240 Downloads
Blood samples were obtained from a total of 17 patients with autism. There were 16 males and 1 female. The age range was from 8 to 23 years with a mean age of 17. The diagnosis of autism conformed to the DSM-III (APA, 1980) and DSM-III-R (APA, 1987) criteria for autism. There were no identified neurobiologic causes of autism in any of the studied population. Parental signed consent was obtained prior to phlebotomy. This study was approved by ethics review committies. Simultaneously drawn blood samples from healthy young adults served as controls for the lymphocyte stimulation studies and for the pokeweed mitogen stimulations. For comparison of IgG anti-central nervous system (CNS) reactivity the results from a study of 348 children were used (Plioplys, 1989). For the IgM results a comparison group of 101 normal young adults was used. For comparison of neural cell adhesion molecule (NCAM) determinations the results from seven physically and neurologically normal controls (4 male, 3 female) were used with a mean age of 19 years.
KeywordsNeural Cell Adhesion Molecule Pervasive Developmental Disorder Optical Density Unit Autistic Patient Draw Blood Sample
Unable to display preview. Download preview PDF.
- American Psychiatric Assocation. (1980). Diagnostic and statistical manual of mental disorders. (3rd ed.). Washington DC: Author.Google Scholar
- American Psychiatric Assocation. (1987). Diagnostic and statistical manual of mental disorders. (3rd rev ed.). Washington DC: Author.Google Scholar
- Cunningham, B. A., Hemperly, J. J., Murray, B. A., Prediger, E. A., Brackenbury, R., Edelman, G. M. (1987). Neural cell adhesion molecule; structure, immunoglobulin-like domains, cell surface modulation, and alternative RNA splicing. Science, 236,799-806.Google Scholar
- Plioplys, A. V., Greaves, A., Yoshida, W. (1989). Anti-CNS antibodies in childhood neurologic diseases. Neuropediatrics (in press).Google Scholar
- Plioplys, A. V., Greaves, A., Kazemi, K., Silverman, E. (1989). Lymphocyte function in autism. Canadian Journal of Neurological Sciensies (abstract in print); manuscript submitted for publication.Google Scholar
- Plioplys, A. V., Greaves, A., Kazemi, K., Silverman, A. (1989). Autism: anti-210K neurofilament immunoglobulin reactivity. Neurology (abstract in print); manuscript submitted for publication.Google Scholar
- Plioplys, A. V., Hemmens, S. E., Regan, C. M. (1989). Expression of a NCAM serum fragment is depressed in autism. Annals of Neurology (abstract in print); manuscript submitted for publication.Google Scholar