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Urolithiasis pp 307-307 | Cite as

2,8-Dihydroxyadenine Stone Formation

  • H. van Ahlen
  • A. Thon
  • H. Birwe
  • A. Hesse

Abstract

Are there reliable methods to detect, evaluate, and monitor adenine phosphoribosyl transferase (APRT) activity, 2,8-dihydroxyadenine (DHA) stone formation, and therapy of the disease? Enzyme deficiency can be characterized by radiochemically measuring the APRT activity in the erythrocyte hemolysate, thus allowing us to study hereditary factors. Using chemical methods of urinary stone analysis, 2,8-DHA stones will constantly be classified as uric acid calculi. Infrared spectroscopy enables us to clearly and reliably identify these stones. For quantitative measurements of 2,8-DHA, we have developed a specific HPLC technique in conjunction with a separating system for purine.

Keywords

Stone Formation Enzyme Deficiency Dramatic Drop Hereditary Factor High Urine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • H. van Ahlen
    • 1
  • A. Thon
    • 1
  • H. Birwe
    • 1
  • A. Hesse
    • 1
  1. 1.Experimentelle UrologieUrologische UniversitätsklinikBonnGermany

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