Abstract
In more recent times, major stress has been placed on the role of inhibitors in urolithiasis. Most urines are supersaturated and high levels of stone promoters would induce spontaneous crystallization but for the presence of adequate amounts of inhibitors (1). However, all the inhibitor substances are yet to be clearly identified, and their relative contribution is to be decided. Amino acids are also reported to be inhibitors but their role is still not clear as contrary reports have appeared in the literature. A high prevalence of urinary stone disease in this region of India stimulated us to undertake various studies on urolithiasis. In the present paper, urinary excretion of amino acids in healthy normal subjects (NS) and stone formers (SF), and the influence of the different amino acids on an in vitro mineralization process are reported.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
LN Pyrah, Chemical substance in urine promoting or preventing renal stone, in: “Renal Calculus,” Springer Verlag, New York (1979).
S Natelson, 1971, “Techniques of Clinical Biochemistry, 3rd Ed.,” Charles C. Thomas.
MG McGeown, The urinary excretion of amino acids in calculus patients, Clin. Sci. 18: 185 (1959).
BA Hum, RG Huntsman, H Lehmann, J Liddell, and AB Roos, Urinary amino acids and calcium in relation to renal stones and renal damage, Clin. Sci. 22: 195 (1962).
WC Thomas, Jr., MH Malagodi, and OM Rannert, 1981, Urinary excretion of amino acids by subjects with renal calculi, in: “Urolithiasis, Clinical and Basic Research,” LH Smith, WG Robertson, and B Finlayson, eds., Plenum Press, New York.
R Azoury, S Sarig, N Garti, and S Perlberg, Retaliation of calcium oxalate precipitation by glutamate oxaloacetate transaminase activity, Urol. Res. 10(4): 169 (1982).
PP Singh, D Verma, A Goyal, and AK Pendse, Hydroxyprolinuria in stone formers and the effect of cystone (a formulation of indigenous drugs) therapy, PROBE 15(4): 345 (1986).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer Science+Business Media New York
About this chapter
Cite this chapter
Hussain, F., Singh, P.P., Pendse, A.K. (1989). Amino Acid Excretion in Urinary Calculous Disease. In: Walker, V.R., Sutton, R.A.L., Cameron, E.C.B., Pak, C.Y.C., Robertson, W.G. (eds) Urolithiasis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0873-5_81
Download citation
DOI: https://doi.org/10.1007/978-1-4899-0873-5_81
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-0875-9
Online ISBN: 978-1-4899-0873-5
eBook Packages: Springer Book Archive