In more recent times, major stress has been placed on the role of inhibitors in urolithiasis. Most urines are supersaturated and high levels of stone promoters would induce spontaneous crystallization but for the presence of adequate amounts of inhibitors (1). However, all the inhibitor substances are yet to be clearly identified, and their relative contribution is to be decided. Amino acids are also reported to be inhibitors but their role is still not clear as contrary reports have appeared in the literature. A high prevalence of urinary stone disease in this region of India stimulated us to undertake various studies on urolithiasis. In the present paper, urinary excretion of amino acids in healthy normal subjects (NS) and stone formers (SF), and the influence of the different amino acids on an in vitro mineralization process are reported.
KeywordsNormal Subject Stone Former Calcium Oxalate Renal Stone Renal Calculus
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