Urolithiasis pp 255-257 | Cite as

Effect of Calcitriol Administration on Urinary Excretion of Nephrocalcin, A Calcium-Oxalate Crystal-Growth Inhibitor

  • E. M. Worcester
  • J. LemannJr.
  • R. W. Gray


Nephrocalcin (NC) is an acidic glycoprotein that contains several residues of gamma-carboxyglutamie acid (Gla), and that inhibits the growth of calcium oxalate (CaOx) monohydrate crystals in vivo (1). Nephrocalcin has been purified from human urine (2), rat kidneys and urine (3), and from culture supernatants of both human and mouse kidney-tissue culture (4, 5). Nephrocalcin isolated from the urine of stone formers has several molecular abnormalities, including an absence of Gla residues and a decreased affinity for crystal surfaces (6). Nephrocalcin may play a role in inhibition of CaOx crystal growth in vivo, thereby preventing formation of kidney stones.


Calcium Oxalate Proximal Tubule Cell Urinary Calcium Excretion Calcium Oxalate Monohydrate Monohydrate Crystal 
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • E. M. Worcester
    • 1
    • 2
  • J. LemannJr.
    • 1
    • 2
  • R. W. Gray
    • 1
    • 2
  1. 1.Department of Medicine and BiochemistryMedical College of WisconsinMilwaukeeUSA
  2. 2.Zablocki VA Medical CenterMilwaukeeUSA

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