Urolithiasis pp 253-254 | Cite as

Calcium-Oxalate Crystal Growth: Influence of Natural Inhibitors

  • K. Kleboth
  • J. Joost


Recurrent calcium oxalate monohydrate (COM) stone formers appear to suffer from a lack of natural inhibitors (1). The following substances have been tested by us for an assessment of their contribution to the inhibitory activity of urine: RNA, chondroitin-4-sulfate (cDS-A), chondroitin-6-sulfate (cDS-c), dermatan sulfate, heparan sulfate, keratan sulfate, and RNA-chondroitin sulfate mixture.


Inhibitory Activity Crystal Growth Heparan Sulfate Effective Inhibitor Calcium Oxalate 
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  1. 1.
    J Joost and K Kleboth, Messung der inhibitoraktivität, in: “Pathogenese und Klinik der Harnsteine XII,” W Vahlensieck and Gasser, eds., Steinkopff-Verlag, Darmstadt (1978).Google Scholar
  2. 2.
    ME Sheehan and GH Nancollas, Calcium oxalate crystal growth, Invest. Urol. 17: 446 (1980).PubMedGoogle Scholar
  3. 3.
    DS Scurr and WG Robertson, Modifiers of calcium oxalate crystallization II. J. Urol. 136: 128 (1986).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • K. Kleboth
    • 1
  • J. Joost
    • 1
  1. 1.Institute of Inorganic and Analytical Chemistry Department of UrologyUniversity of InnsbruckInnsbruckAustria

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