Decreased Erythrocyte Glycosaminoglycan Content in Idiopathic Calcium-Oxalate Nephrolithiasis
In red blood cells (RBC) of idiopathic calcium-oxalate stone formers (ISF), we previously demonstrated an abnormal transmembrane self-exchange (SE) of oxalate (1). The molecular basis of this anomaly seems to be an altered phosphorylation state of band-3 protein, the anion-carrier, probably resulting from an increased activity of protein kinases (2). Since glycosaminoglycans (GAG) are known inhibitors of protein kinases, we tested the hypothesis that a fall in GAG concentration in RBC membranes might be responsible for the increased phosphorylation of band-3 protein.
KeywordsProtein Kinase Negative Correlation Membrane Protein Molecular Basis Significant Negative Correlation
- 2.B Baggio, G Clari, G Marzaro, G Gambaro, A Borsatti, and V Moret, Contr. Nephrol. 58: 156 (1987).Google Scholar